Field testing updates on the control of the cacao mirid bug, Heliopeltis bakeri Poppius

Cocoa from the economic crop Theobroma cacao L. was recognized in different industries for its health benefits. Supply deficit foreseen as the demand increases, where pest infestations pose great impact to hinder the increase in production. Cacao mirid bug (Helopeltis bakeri Poppius) is one of the emerging pests of cacao, causing lesions that renders cacao useless and unmarketable. Currently, there is little to no information regarding the biology of H. bakeri in the Philippines and studies are still underway. The use of semiochemicals is a program of IPM that confuse, attract, and catch pests in a biologically based way. In this study, potential kairomone and pheromone compounds were tested for the control of H. bakeri. Using wind tunnel behavioral bioassay, four potential trap designs: pyramid trap (PT); rectangular trap (RT); green sticky board (GSB) and bottle trap (BT), were tested using the compound β-caryophyllene as potential kairomone. Results showed that RT and GSB has the highest H. bakeri catch to 50% and 46.67%, respectively. Statistical analysis showed RT (

Attraction of cacao mirid bug (Helopeltis bakeri Poppius) to feeding attractant β-Caryophyllene using wind tunnel behavioral bioassay

Theobroma cacao L. produces cocoa, the main ingredient for the production of chocolates. It is a high value agricultural crop recognized for various health benefits and due to this, the demand continues to increase. Cacao mirid bug (Helopeltis bakeri) is one of the emerging pests of cacao and it feeds and oviposit on the pods, causing lesions that renders cacao unmarketable. The use of semiochemicals is a program of IPM applied to confuse, attract, and trap pests in a biologically based way. This study aimed to evaluate the attraction of H. bakeri towards the potential feeding attractant β-Caryophyllene, determine the optimum concentration and assessed different trap designs using wind tunnel behavioral bioassays. Results showed that among treatments (45μg, 65μg, 90μg and 180μg β-caryophyllene), 90μg attracted the highest number of H. bakeri (75.05%) and was highly significant (

The Nucleolin Antagonist N6L Inhibits LINE1 Retrotransposon Activity in Non-Small Cell Lung Carcinoma Cells

Lung cancer is the most common cause of cancer death in the United States. The genome of non-small cell lung cancer (NSCLC), the most frequent lung cancer type, is strongly affected by Long Interspersed Nuclear Element (LINE1) insertions. Active LINE1s are repetitive DNA sequences that can amplify themselves in the genome utilizing a retrotransposition mechanism whereby LINE1 is copied via reverse transcription and inserted at target sites. ORF1p and ORF2p are LINE1 encoded proteins essential for LINE1 retrotransposition. LINE1s are silenced epigenetically in somatic tissues, and their reactivation has been associated with cancer pathogenesis. Here, we present evidence that nucleolin (NCL) regulates expression of LINE1-ORF1p (L1-ORF1p) in NSCLC cells. Genetic knockdown of NCL significantly inhibited expression of L1-ORF1p in various NSCLC cell lines. Treatment with the investigational NCL antagonist N6L ablated L1-ORF1p expression in all cell lines constitutively expressing L1-ORFp. N6L displayed a stronger antiproliferative activity in NSCLC tumor cell lines expressing the highest L1-ORF1p protein levels. Moreover, N6L treatment of nude mice bearing NSCLC tumor xenografts blocked L1-ORF1p expression and effectively inhibited tumor growth. These data indicate that L1-ORF1p expression is regulated by NCL and identify NCL as a novel promising target for pharmacological inhibition of LINE1.America Cancer Society [IRG-16-124-37]; University of Arizona Career Development Award; GURI Award; Agence National pour la RechercheFrench National Research Agency (ANR) [ANR-16 CE17-0023]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Field evaluation of the sex pheromone of the cacao pod borer (Conopomorpha cramerella Snellen) in the Philippines

Cacao is a promising high-value crop in the Philippines and is considered one of the key players globally in providing the raw materials for chocolate making. However, before the Philippines can take this market opportunity, production constraints from various pests should be addressed. The cacao pod borer (CPB), Conopomorpha cramerella, is one of the major insect pests of cacao in the Philippines, which can cause up to 50% annual loss or even higher if proper management is not employed. Management of CPB heavily relies on chemical control but is becoming unpopular because of its high cost and health risk to people and the environment. A number of efforts have been made to develop sex pheromones to monitor and control CPB. A field bioassay of the new blend of CPB sex pheromones was conducted in southern Philippines to determine its efficiency and identify the appropriate trap height placement in a cacao field, which is important in maximizing the efficiency of the sex pheromone traps for inclusion in the integrated pest management (IPM) program of CPB. Pheromone lures at four different trap heights (1.0 m, 0.5 m above the canopy, 0.0 m or along the canopy, and 0.5 m below the canopy) and a blank lure (control) placed 1.0 m above the canopy were evaluated in terms of male CPB trap catches. Results showed significantly higher male CPB trap catches when installed at least 0.5 m above the canopy while minimal to zero male CPB catches were obtained from the control traps with blank lures, confirming the attractiveness of the new blend of the CPB sex pheromone in the field. This suggests the reliability of the pheromone-based method to monitor and control CPB and as a major component of the IPM program

Non-additive effects of ACVR2A in preeclampsia in a Philippine population

Abstract Background Multiple interrelated pathways contribute to the pathogenesis of preeclampsia, and variants in susceptibility genes may play a role among Filipinos, an ethnically distinct group with high prevalence of the disease. The objective of this study was to examine the association between variants in maternal candidate genes and the development of preeclampsia in a Philippine population. Methods A case-control study involving 29 single nucleotide polymorphisms (SNPs) in 21 candidate genes was conducted in 150 patients with preeclampsia (cases) and 175 women with uncomplicated normal pregnancies (controls). Genotyping for the GRK4 and DRD1 gene variants was carried out using the TaqMan Assay, and all other variants were assayed using the Sequenom MassARRAY Iplex Platform. PLINK was used for SNP association testing. Multilocus association analysis was performed using multifactor dimensionality reduction (MDR) analysis. Results Among the clinical factors, older age (P <  1 × 10–4), higher BMI (P <  1 × 10–4), having a new partner (P = 0.006), and increased time interval from previous pregnancy (P = 0.018) associated with preeclampsia. The MDR algorithm identified the genetic variant ACVR2A rs1014064 as interacting with age and BMI in association with preeclampsia among Filipino women. Conclusions The MDR algorithm identified an interaction between age, BMI and ACVR2A rs1014064, indicating that context among genetic variants and demographic/clinical factors may be crucial to understanding the pathogenesis of preeclampsia among Filipino women

Report on the 5th International Meeting of the IUGS Lower Cretaceous Ammonite Working Group, the Kilian Group (Ankara, Turkey, 31st August 2013)

The 5th meeting of the IUGS Lower Cretaceous Ammonite Working Group (the Kilian Group) held in Ankara, Turkey, 31st August 2013, discussed the Mediterranean ammonite zonation, and its calibration with different ammonite zonal schemes of the Boreal, Austral and Central Atlantic realms. Concerning the standard zonation, that corresponds to the zonal scheme of the West Mediterranean province, some changes have been made on two stages. For the Valanginian, the Busnardoites campylotoxus Zone was abandoned; the upper part of the lower Valanginian is now characterised by the Neocomites neocomiensiformis and Karakaschiceras inostranzewi zones. For the upper Barremian, the former Imerites giraudi Zone is here subdivided into two zones, a lower I. giraudi Zone and an upper Martellites sarasini Zone. The I. giraudi Zone is now subdivided into the I. giraudi and Heteroceras emerici subzones, previously considered as horizons. The current M. sarasini and Pseudocrioceras waagenoides subzones correspond to the lower and upper parts of the M. sarasini Zone, respectively. The Anglesites puzosianum Horizon is kept. The Berriasian, Hauterivian, Aptian and Albian zonal schemes have been discussed but no change was made. The upper Hauterivian zonal scheme of the Georgian (Caucasus) region (East Mediterranean province) has been compared with the standard zonation. Discussions and some attempts at correlations are presented here between the standard zonation and the zonal schemes of differen

Tratados de artes figurativas [Recurso electrónico]

PC 486; 8 Mb de memoria RAM, recomendado 16 MB; MS-DOS 6.0 y Microsoft Windows 3.1 o superior; Espacio libre en disco local superior a 10 Mb; Monitor VGA, recomendado SVGA, resolución 800x600, 256 colores; Lector de CD-ROM local o en red.Tít. tomado de la etiquetaArce y Cacho, Celedonio Nicolás De: Conversaciones sobre la escultura: compendio historico, teorico y practico de ella... En Pamplona: Por Joseph Longas, 1786. -- Arfe y Villafañe, Juan: Qvilatador de la plata, oro, y piedras. Impresso en Valladolid: por Alonso y Diego Fernandez de Cordoua, 1572. -- Arfe y Villafañe, Juan: De varia commensvracion para la escvltvra, y Architectura. En Sevilla: En la imprenta de Andrea Pescioni y Iuan de Leon, 1585. -- Arteaga, Esteban De: Investigaciones filosoficas sobre la belleza ideal, considerada como objeto de todas las artes de imitación. En Madrid: Por don Antonio de Sancha, 1789. -- [Butrón, Juan De]: Epístola dirigida al rey solicitando protección para la Academia. [S. l.]: [s. n.], [s. d.]. -- Butrón, Juan De: Discvrsos apologeticos en qve se defiende la ingenvidad del arte de la pintvra... En Madrid: Por Luis Sánchez, 1626. -- Cabrera, Claudio Antonio De: Ivizio de artes y sciencias. En Madrid: por Iulian de Paredes, 1655. -- Carducho, Vincencio: Dialogo de la pintvra sv defensa, origen, essencia, definicion, modos y diferencias. [En Madrid]: Impresso con licencia por Francisco Martínez, 1633. -- Caveda, José: Memorias para la Historia de la Real Academia de San Fernando... [2 vol.]. Madrid: [s. n.] (Imprenta de Manuel Tello), 1867. -- Ceán Bermúdez, Juan Agustín: Diccionario historico de los mas ilustres profesores de Bellas Artes en España [6 vol.]. Madrid: Real Academia de San Fernando, 1800. -- Ceán Bermúdez, Juan Agustín: Ocios de Don Juan Agustín Cean-Bermudez sobre Bellas Artes: (hasta ahora ineditos). Madrid: [s. n.] (Imprenta de Berenguillo), 1870. -- Copia de los pareceres, y censvras de los reverendissimos padres maestros... En Madrid: Por la vivda de Alonso Martin, 1632. -- Elogios al Palacio Real del Bven Retiro. En Madrid: En la Imprenta del Reyno, 1635. -- Esquivel, Antonio María: Tratado de anatomía pictórica... Madrid: [s. n.] (Imprentra de Don Francisco Andrés y Compañía), 1848. -- Estatutos de la Real Academia de San Fernando. En Madrid: En Casa de D. Gabriel Ramírez, 1757. -- Galofre, José: El artista en Italia y demas paises de Europa... Madrid: Monier (Imprenta de L. García), 1851. -- García De La Huerta, Pedro: Comentarios de la pintura encáustica del pincel. En Madrid: En la Imprenta Real, 1795. -- Giner, Hermenegildo: Teoría del arte e historia de las artes bellas en la antigüedad. Baeza: Imp. y lib. de la Comisión general de libros, 1873. -- Giner, Hermenegildo: Filosofía y arte. Madrid: [s. n.] (Imprenta de M. Minuesa de los Ríos), 1878. -- Guevara, Felipe De: Comentarios de la pintura. Madrid: Por don Gerónimo Ortega, hijos de Ibarra y compañia, 1788. -- Gutiérrez De Los Ríos, Gaspar: Noticia general para la estimación de artes... En Madrid: Por Pedro Madrigal, 1600. -- Haes, Carlos De: De la pintura de paisaje antigua y moderna... [S. l.]: [s. n.], [s. d.]. (**) -- Interian De Ayala, Juan: El pintor christiano, y erudito, ó tratado de los errores... [2 vol.]. Madrid: Por D. Joachín Ibarra, 1782. -- Madrazo, Pedro De: Catálogo de los cuadros del Real Museo de Pintura y Escultura de S.M.Madrid: [s. n.] (Oficina deAguado, Impresor de Cámara), 1843. -- Manjarres y De Bofarull, José De: Teoría é Historia de las Bellas Artes... Barcelona: Librería de Joaquín Verdaguer, 1859. -- Martínez, Francisco: Introduccion al conocimiento de las Bellas Artes o Diccionario manual de Pintura, Escultura, Arquitectura, Grabado, etc. Madrid: Por la Viuda de Escribano, 1788. -- Martínez, Juseppe: Discursos practicables del nobilísimo arte de la pintura... Madrid: Real Academia de San Fernando, 1866. -- Mendoza, Francisco De: Manual del pintor de historia... Madrid: [s. n.] (Imprenta de T. Fontanet), 1870. -- Mengs, Antonio Rafael: Obras de D. Antonio Rafael Mengs, primer pintor de camara del rey. En Madrid: Por don Joseph Nicolas de Azara, 1780. -- Moreno De Tejada, Juan: Excelencias del pincel y del buril... Madrid: En la Imprenta de Sancha, 1804. -- Pacheco, Francisco: Arte de la pintvra, sv antigvedad y grandezas. En Sevilla: Por Simón Faxardo, impressor de libros, a la Cerrajeria, 1649. -- Palomino De Castro y Velasco, Antonio: El museo pictorico y escala optica [3 vol.]. EnMadrid: Por LucasAntonio de Bedmar, Impresor del Reyno, 1715. -- Pi y Margall, Francisco: Historia de la Pintura en España... Madrid: [s. n.] (Imprenta à cargo de Manini hermanos), 1851. -- Rejón De Silva, Diego Antonio: La Pintura: Poema didactico en tres cantos. En Segovia: Por Don Antonio Espinosa de los Monteros, 1786. -- Tebano, Parraiso: Arcadia pictórica en sueño, alegoría ó poema prosaico sobre la teórica y práctica de la pintura. Madrid: Por Don Antonio de Sancha, 1789

Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement

International audienceDrug hypersensitivity reactions (DHRs) to intravenous drugs can be severe and might leave patients and doctors in a difficult position where an essential treatment or intervention has to be suspended. Even if virtually any intravenous medication can potentially trigger a life-threatening DHR, chemotherapeutics, biologics, and antibiotics are amongst the intravenous drugs most frequently involved in these reactions. Admittedly, suspending such treatments may negatively impact the survival outcomes or the quality of life of affected patients. Delabeling pathways and rapid drug desensitization (RDD) can help reactive patients stay on first-choice therapies instead of turning to less efficacious, less cost-effective, or more toxic alternatives. However, these are high-complexity and high-risk techniques, which usually need expert teams and allergy-specific techniques (skin testing, in vitro testing, drug provocation testing) to ensure safety, an accurate diagnosis, and personalized management. Unfortunately, there are significant inequalities within and among countries in access to allergy departments with the necessary expertise and resources to offer these techniques and tackle these DHRs optimally. The main objective of this consensus document is to create a great benefit for patients worldwide by aiding allergists to expand the scope of their practice and support them with evidence, data, and experience from leading groups from around the globe. This statement of the Drug Hypersensitivity Committee of the World Allergy Organization (WAO) aims to be a comprehensive practical guide on the technical aspects of implementing acute-onset intravenous hypersensitivity delabeling and RDD for a wide range of drugs. Thus, the manuscript does not only focus on clinical pathways. Instead, it also provides guidance on topics usually left unaddressed, namely, internal validation, continuous quality improvement, creating a healthy multidisciplinary environment, and redesigning care (including a specific supplemental section on a real-life example of how to design a dedicated space that can combine basic and complex diagnostic and therapeutic techniques in allergy)