Is trans-radial approach related to an increased risk of radiation exposure in patients who underwent diagnostic coronary angiography or percutaneous coronary intervention? (The SAKARYA study)

Conclusion: In spite of an increased experience with trans-radial approach, PCI of coronary lesions via radial route was associated with a relatively small but significant radiation exposure in our study. Compared to femoral access, diagnostic CA via radial access was not related to an increased radiation exposure

Crizotinib efficacy and safety in patients with advanced NSCLC harboring MET alterations: A real-life data of Turkish Oncology Group

Crizotinib is a multikinase inhibitor, effective in non-small cell lung cancer (NSCLC) harboring mesenchymal-epidermal transition (MET) alterations. Although small prospective studies showed efficacy and safety of crizotinib in NSCLC with MET alterations, there is limited real-life data. Aim of this study is to investigate real-life efficacy and safety of crizotinib in patients with advanced NSCLC harboring MET alterations. This was a retrospective, multicenter (17 centers) study of Turkish Oncology Group. Patients' demographic, histological data, treatment, response rates, survival outcomes, and toxicity data were collected. Outcomes were presented for the study population and compared between MET alteration types. Total of 62 patients were included with a median age of 58.5 (range, 26-78). Major histological type was adenocarcinoma, and 3 patients (4.8%) had sarcomatoid component. The most common MET analyzing method was next generation sequencing (90.3%). MET amplification and mutation frequencies were 53.2% (n = 33) and 46.8% (n = 29), respectively. Overall response rate and disease control rate were 56.5% and 74.2% in whole study population, respectively. Median progression free survival (PFS) was 7.2 months (95% confidence interval [CI]: 3.8-10.5), and median overall survival (OS) was 18.7 months (95% CI: 13.7-23.7), regardless of treatment line. Median PFS was 6.1 months (95% CI: 5.6-6.4) for patients with MET amplification, whereas 14.3 months (95% CI: 6.7-21.7) for patients with MET mutation (P = .217). Median PFS was significantly longer in patients who have never smoked (P = .040), have good performance score (P < .001), and responded to the treatment (P < .001). OS was significantly longer in patients with MET mutation (25.6 months, 95% CI: 15.9-35.3) compared to the patients with MET amplification (11.0 months; 95% CI: 5.2-16.8) (P = .049). In never-smokers, median OS was longer than smoker patients (25.6 months [95% CI: 11.8-39.3] vs 16.5 months [95% CI: 9.3-23.6]; P = .049). The most common adverse effects were fatigue (50%), peripheral edema (21%), nausea (29%) and diarrhea (19.4%). Grade 3 or 4 adverse effects were observed in 6.5% of the patients. This real-life data confirms efficacy and safety of crizotinib in the treatment of advanced NSCLC harboring MET alteration

Relationship between burnout and work load: A research on Aksaray revenue offi̇ce

Bu çalışmanın amacı, Defterdarlık çalışanlarının sosyo-demografik özelliklerine göre tükenmişlik ve iş yükü algısını incelemektir. Bu amaçla, Aksaray da hizmet veren Aksaray Defterdarlığı kurum çalışanlarından oluşan örneklemimizden anket vasıtasıyla bilgiler toplanmıştır. 154 anket verilerin çözümlenmesinde kullanılmıştır. Çalışmamızın bulguları, iş yükünün, tükenmişlik üzerinde etkili olduğunu göstermiştir. Sosyo-demografik özellikler ile tükenmişlik algısı ve iş yükü algısı arasındaki ilişkilerden farklı farklı sonuçlar çıkarken, İş yükü ile tükenmişlik algısı arasında pozitif doğrultuda anlamlı bir ilişki mevcuttur. Çalışmanın iki önemli kıstı bulunmaktadır. İlki, araştırmanın sadece Aksaray Defterdarlığında yapılması nedeniyle çalışma bulgularının genel olarak tüm maliye çalışanlarını kapsamaması. İkinci olarak, araştırmada veriler anket yöntemi ile toplandığından anketi cevaplayan kamu görevlilerinin soruları cevaplarken konuyu tam olarak kavrayamamalarından dolayı ya da benzeri nedenlerden sağlıklı cevaplar verememiş olmalarıdır.The purpose of this study is to examine burnout and workload perception of employees of the tax and revenue office according to their demografic characteristics. For this reason, the data were gathered by the survey method from the employees of Aksaray main and revenue office. 154 questionnaire were used for the analysis of data. The results of our study showed that workload had an effect upon burnout. While getting different results about correlation between socio-demographic characteristics and burnout, workload perception, the correlation between workload and perception is positive. In this study there are two limitations. Firstly, as the research is done only Aksaray tax and revenue office, the study results does not represent all of tax and revenue employees. Secondly, as the data are gathered by survey method, the respondents may not understand the subject and they may not give satisfactory answers because of various reasons

Abused android permissions by advertising networks

Android is the leading mobile operating system for smart phone and mobile tablet platforms. Since these mobile devices contain personal and sensitive data, security is a big challenge for them. Even though various security features are supported by Android, its permission model is quite problematic from usability and privacy aspects. When users want to install an application, they must grant all requested permissions. Since manually checking dozens of permissions is cumbersome, users ignore it and accept permissions without reading them. In Google Play Store, there exist thousands of applications that request more permissions than they actually need. Applications with unnecessary permissions can misuse their permissions and endanger their users' security and privacy. Especially, advertising network libraries, integrated within applications, request many unnecessary permissions and get unauthorized access to users' personal data. In this paper, we explain the results of our study which analyzes several advertising networks, their permission requests and behavior for accessing critical resources.IEEEIEEE Computer SocietyInst Creative Advanced Technologies Sci & EngnUniversity of Science and Technology BeijingKyonggi UniversityKorea Ind Security ForumKorean Convergence Security Asso

The content analysis of bıst 100 firms’ mission, vision, organizational values and purposes

Bu çalışmanın amacı 2017 yılı itibari ile Borsa İstanbul’da işlem gören firmaların misyon, vizyon, örgütsel değer ve stratejik amaçlarına ilişkin ifadeleri içerik analizi yöntemi ile incelemektir. Daha genel bir ifade ile çalışma ülke ekonomisinin nabzını tutan BİST 100 firmalarının açıkladıkları misyon, vizyon, örgütsel değer ve stratejik amaçlarında öne çıkan ve öncelik ifade eden kavramları belirlemektedir. Bu çalışmanın motivasyonunu lider, yönetici, işletme sahibi ve karar organlarına örgütleri için misyon, vizyon, örgütsel değer ve stratejik amaçlar belirlerken yol göstermek, hangi kavramlara odaklanmaları gerektiği konusunda yardımcı olmaktır. Yine ülkemiz öncü firmalarının faaliyetlerine yol vermelerinde yardımcı olan misyon, vizyon, örgütsel değer ve stratejik amaçlarına ilişkin literatürdeki benzer çalışmalarla kıyaslamalar yaparak zaman içindeki kavramsal değişimleri ortaya koymaktır. Araştırma sonucunda işletmelerin vizyon açıklamalarında liderlik ve yenilikçilikten vazgeçmeden gelişen dünya ekonomisi ve piyasa koşullarında hayatta kalabilmek için küreselleşme ve sürdürülebilirlik kavramlarına öncelik verdikleri tespit edilmiştir. Yine firmaların misyon açıklamalarında sürdürülebilirlik, katma değer yaratma, çevreye duyarlılık, kalite ve liderlik gibi kavramların önemli yere sahip olduğu; firmaların örgütsel çıktılar ve bu çıktıların getirilerine ilişkin amaçsal değerlere ve amaç ifadelerinde ise sürdürülebilirliğe odaklandıkları görülmektedir.The purpose of this study is to analyze the statements regarding the mission, vision, organizational values and strategic aims of the companies traded on the Stock Exchange Istanbul by content analysis method as of 2017. More generally, the study identifies concepts that stand out in the mission, vision, organizational values and objectives of BIST 100 companies that hold the pulse of the country's economy. The motivation of this work is to guide the leaders, managers, business owners and decision-making bodies in determining their mission, vision, organizational values and goals for their organizations, and to help them focus on which concepts. Also, our country is to demonstrate conceptual changes over time by making comparisons with similar studies in the literature on mission, vision, organizational values and objectives that helped lead companies to their activities. As a result of research, it has been found that businesses prioritize the concepts of globalization and sustainability in order to survive in the world economy and market conditions that develop without giving up leadership and innovation in vision statements. It is also important to note that companies have important concepts such as sustainability, added value creation, environmental awareness, quality and leadership in mission statements; it is seen that companies focus on organizational outputs and sustainability in terms of objective values and purpose expressions regarding the bring-in of these outputs

Relatıonship between burnout and work load: A research on Aksaray revenue office

*Bu çalışma Aksaray Üniversitesi Sosyal Bilimler Enstitüsü İşletme Anabilim Dalı Yönetim ve Organizasyon Bilim Dalı Tezli Yüksek Lisans Programı kapsamında 2017 yılında hazırlanmış olan yüksek lisans tezinden üretilmiştir.Bu çalışmanın amacı, Defterdarlık çalışanlarının sosyo-demografik özelliklerine göre tükenmişlik ve iş yükü algısınıincelemektir. Bu amaçla, Aksaray da hizmet veren Aksaray Defterdarlığı kurum çalışanlarından oluşan örneklemimizden anket vasıtasıyla bilgiler toplanmıştır. 154 anket verilerin çözümlenmesinde kullanılmıştır. Çalışmamızın bulguları, iş yükünün, tükenmişlik üzerinde etkili olduğunu göstermiştir.Sosyo-demografik özellikler ile tükenmişlik algısı ve iş yükü algısı arasındaki ilişkilerden farklı farklı sonuçlar çıkarken, İş yükü ile tükenmişlik algısı arasında pozitif doğrultuda anlamlı bir ilişki mevcuttur. Çalışmanın iki önemli kıstı bulunmaktadır. İlki, araştırmanın sadece Aksaray Defterdarlığında yapılması nedeniyle çalışma bulgularının genel olarak tüm maliye çalışanlarını kapsamaması. İkinci olarak, araştırmada veriler anket yöntemi ile toplandığından anketi cevaplayan kamu görevlilerinin soruları cevaplarken konuyu tam olarak kavrayamamalarından dolayı ya da benzeri nedenlerden sağlıklı cevaplar verememiş olmalarıdır.The purpose of this study is to examine burnout and workload perception of employees of the tax and revenue Office according to their demografic characteristics. For this purpose, the data were gathered by the survey method from the employees of Aksaray revenue office. 154 questionnaires were used for the analysis of data. The results of our study showed that workload had an effect on burnout. While getting different results about correlation between socio-demographic characteristics and burnout, workload perception, the correlation between workload and perception is positive. In this study there are two limitations. Firstly, as the research is done only at Aksaray tax and revenue office, the study results do not represent all of tax and revenue employees. Secondly, as the data are gathered by survey method, the respondents may not give satisfactory answers due to various reasons

Acute pancreatitis linked to bevacizumab: A case report

Introduction: The monoclonal anti-vascular endothelial growth factor antibody bevacizumab is increasingly being used in the treatment of malignant tumors. It is the first molecular-targeted agent used in the treatment of several ovarian cancers. The typical side effects of this drug are hypertension and proteinuria. Bevacizumab-related acute pancreatitis (AP) has not been described before, but AP associated with other chemotherapeutic agents has been reported. Research has shown that patients can develop AP when taking sorafenib, a multiple tyrosine kinase inhibitor that inhibits VEGF. Case presentation: We explored the case of a 48-year-old woman who presented with undefined upper abdominal pain after receiving a cisplatin-gemcitabine-bevacizumab combination treatment as second-line therapy for metastatic ovarian cancer. Our patient was hospitalized because of AP after two cycles of this treatment. The patient started experiencing abdominal pain after the first course of chemotherapy. The severity and duration of this pain increased after the second cycle of chemotherapy. Her abdominal pain and elevated serum amylase disappeared when treated by chemotherapy without bevacizumab; this also improved her clinical pancreatitis. Conclusions: AP without other etiological factors can occur in patients treated by chemotherapy. Furthermore, bevacizumab might induce the side effects of AP

Automated generation of attack graphs using NVD

8th ACM Conference on Data and Application Security and Privacy (2018 : Tempe; United States)Today’s computer networks are prone to sophisticated multi-step, multi-host attacks. Common approaches of identifying vulnerabilities and analyzing the security of such networks with naive methods such as counting the number of vulnerabilities, or examining the vulnerabilities independently produces incomprehensive and limited security assessment results. On the other hand, attack graphs generated from the identified vulnerabilities at a network illustrate security risks via attack paths that are not apparent with the results of the primitive approaches. One common technique of generating attack graphs requires well established definitions and data of prerequisites and postconditions for the known vulnerabilities. A number of works suggest prerequisite and postcondition categorization schemes for software vulnerabilities. However, generating them in an automated way is an open issue. In this paper, we first define a model that evolves over the previous works to depict the requirements of exploiting vulnerabilities for generating attack graphs. Then we describe and compare the results of two different novel approaches (rule-based and machine learning-employed) that we propose for generating attacker privilege fields as prerequisites and postconditions from the National Vulnerability Database (NVD) in an automated way. We observe that prerequisite and postcondition privileges can be generated with overall accuracy rates of 88,8 % and 95,7 % with rule-based and machine learning-employed (Multilayer Perceptron) models respectively.ACM SIGSA