CHANGE OF ECG PARAMETERS DEPENDING ON THE LOAD LEVEL IN ATHLETES

The influence of physical training on bodies of athletes leads to changes that can be characterized as morphological, functional, electrophysiological and psychological. Dynamic exercise, such as running, swimming and riding a bicycle, leads to volume load of heart. Static exercise (gymnastics, weightlifting, wrestling) leads to the development of relatively large muscle force, with or without changes in muscle length and movement of the joint. Given the frequent number of sudden cardiac death cases in sport, it is important to distinguish between changes of the heart that occur as a result of adaptation to physical activity and changes due to some pathological conditions. The aim of this paper is to present the latest information on changes in ECG parameters depending on the load of athletes while performing aerobic trainings in order to better identify markers of adverse cardiovascular events, particularly sudden death in athletes. It is common to see on the ECG of athletes at rest hypertrophy of the left and right ventricle, interventricular conduction disorder, positive ST changes, and short-term tachycardia. Changes that occur in athletes are due to increased vagal tone and suppression of sympathetic nerve regulation. Many changes can be attributed to intrinsic cardiac component that is responsible for the lower frequency of athlete's heart deinnervation (with atropine or propranolol), which means that intense training influences how the autonomic regulation and the intrisic cardiac pacemaker function. It is common for athletes to have sinus bradycardia, sinus arrhythmia, first degree AV block and Mobitz I, as well as junctional rhythm, ST segment elevation, high and sharp, or biphasic T-waves, while ST depression or isolated T-wave inversion are less common. They can also have increased amplitude of P-wave and QRS complex, QRS axis rotation to the right and incomplete right branch block. Some but insufficient data tell about the presence of the third-degree AV block and atrial and ventricular ectopic beats and their predictive role for malignant rhythm disorders

A POSSIBLE WAY OF PERFORMING THE STADIUM RACE AT THE FESTIVITY GAMES IN OLYMPIA

The subject of this paper is a complex one, given that it deals with track and field, history, history of art and archeology. Intensive studies in this field began with the renewed Olympic Games in Athens in 1896. The beginning of the new millennium and modern technology have brought the first attempts at animation regarding the possible ways of performing the events at the ancient Olympic Games, among which was the stadium race. The problems that arose with the progress of a one-stade track and field race through a period of 12 centuries at the Festivity Games in Olympia can be solved integrally through aspects of axiological, epistemological and ontological questions, as well as through the experimental method of a possible way of performing the one-stade track and field race, which was represented at the Festivity Games in Olympia. Different analyses, descriptions, hypotheses and views by many authors dealing with the subject of ancient track and field events and way they were performed were the reason for this study in light of a possible way of performing the stadium race. The aim of this study was to define the most authentic way of performing the stadium race at the ancient Olympic Games. Historical and experimental methods were used in this study. Research results indicate that there were differences in this event was performed during the 12 centuries of life of the Festivity Games in Olympia. The research has been justified by an effort to clarify existing scientific hypotheses concerning a possible manner of performing the one-stade race at the ancient Olympic Games.

THE DIFFERENCES IN BMI VALUES BETWEEN TOP FOOTBALL AND VOLLEYBALL PLAYERS

The athletes are, as well as the other population groups, exposed to danger of being overweight. Therefore, it is necessary to constantly control their body composition. The goal of this research is to determine the differences in BMI values between measured groups of football and volleyball players, so we could determine if the specifics of the training process of the observed sports have some influence on the BMI values. The population studied consisted of 100 male athletes of the top national competition rank (57 football players and 43 volleyball players), age 18 – 30. The variables measured are body height and body weight. The BMI of both groups was calculated based on these measures and compared with T-test (sig≥95%). The values produced by T test (sig=83,8%) indicate that there isn’t a significant statistical difference between these groups. We concluded that despite the differences in selection and training processes, the practice of professional top sport provides that body composition values are kept in the boundaries of normal values

VEŽBANJE KAO FAKTOR MODIFIKACIJE NIVOA KORTIZOLA

Cortisol is a glucocorticoid hormone secreted from the adrenal cortex and it represents a key component of the hormonal hypothalamic-pituitary-adrenal axis. The best-known metabolic effects of cortisol on the metabolism are the stimulation of gluconeogenesis, increased protein catabolism and increased lipolysis. Exercise is considered as a specific stressor that can modify the cortisol levels in the human body. The intensity and duration of exercise are factors that determine the response of cortisol. This article is a brief review on the effects of the cortisol responses at different intensity of exercise, its relationship with testosterone and highlights the importance of its role as a hormonal component of adaptation of the organism to exercise that preserves and protects the body from the negative physiological consequences

Churg-Strauss syndrome

Churg-Strauss syndrome (CSS) is medium blood vessels vasculitis with predilection for lungs in patients with bronchial asthma, chronic eosinophilic pneumonia and positive ANCA in the sera in 55-67%. This is a case report of a 60 years old female patient with bronchial asthma, peripheral pulmonary infiltrations, blood eosinophilia, xerophtalmia, tachycardia, chronic rhino sinusitis, polyneuropathia and negative immunological tests: CIC (PEG), CRYO, ANA (IIF), RF (agglutination) and ANCA (IIF: pANCA and cANCA; ELISA: proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G). Eosinophilic infiltrates in the tissues tested by skin and salivary gland biopsies were not found. The patient had fulfilled five clinical diagnostic criteria and responded well to immunosuppressive therapy, so this case could be classified as the ANCA negative angiitis and granulomatous of CSS type

The difference between height-weight relations and nourishment of seven-year-old pupils measured in 1988. and 2008.

Hypokinesia or low level of physical activity typical for the modern way of living, together with the consumed calories that cannot be burnt, lead to the increased weight which is above the average weight for a particular person. The presence of obesity from the day of birth to the old age is increasing in the world, and it may be stated that it is increasing in Serbia as well. The aim of this research is to establish the difference between height-weight relations and nourishment of seven-year-old pupils, measured in 1988 and 2008. The sample comprised primary school pupils, 7 years of age, from Nis, measured in 1988 and 2008. The number of examinees was 524, 257 boys measured in 1988, 91 boys measured in 2008, 91 girls measured in 1988, 85 girls measured in 2008. The results of this research showed that male pupils measured in 1988 had, statistically significan lower body weight, body mass index, average volume of the chest, skin folds, and had lower levels of fat in the body. Female pupils measured in 1988 had lower values of height, weight, body mass index, average chest volume, skin folds and lower levels of fat. The percentage of normally fed pupils measured in 1988 was 88.3%, while the percentage of those measured in 2008 was 59.3%. The relationship between 1988 and 2008 is 92.3% to 56.5%, in female pupils. The number of obese male and female pupils was significantly increased in 2008

Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids

Glucocorticoid (GC) sensitivity depends on glucocorticoid receptor (GR) and heat shock proteins (Hsps). We investigated whether common GR genes (ER22/23EK N363S, BclI, and 9 beta) and adrenocorticotropin receptor promoter polymorphisms influence susceptibility for unilateral adrenal incidentaloma (AI), plus GR and Hsp expression in tumorous (n = 19), peritumorous (n = 13) and normal adrenocortical (n = 11) tissues. Patients (n = 112), population-matched controls (n = 100) and tumor tissues (n = 32) were genotyped for these polymorphisms. Postdexamethasone serum cortisol was higher in patients (p<0.001). GR gene variants, larger allele of BclI (odds ratio (OR) 2.9; 95% confidence interval (CI) 1.7-5.1; p < 0.001) and minor allele of 9 beta (OR 3.0; 95% CI 1.6-5.7; p < 0.001) were independent predictors of Al. In patients, the first allele is linked with larger tumors (p = 0.002) and the latter with higher postdexamethasone cortisol levels (p = 0.025). Both allele carriers had lesser waist circumference (p = 0.02), similar adrenocorticotropin and higher basal (p = 0.024) and postdexamethasone cortisol concentrations (p < 0.001). Tumorous and constitutional genotypes were similar. GR-D is the major receptor isoform in normal adrenal cortex by Western blotting. Loss of other receptor isoforms, decrease in immunostaining for GR (p < 0.0001), underexpression of chaperones (p <= 0.01) and the presence of inducible Hsp70 were found in adenomas. In conclusion, GR gene variants, C allele of BclI and minor allele of 9 beta, are associated with Als. Their concurrent presence in patients reduces GC sensitivity Normal adrenal cortex preferentially expresses GR-D. In adenomas, the lack of other GR isoforms and underexpression of heat shock proteins perhaps permanently impair GC signaling, which could promote dysregulated cortisol production and tumor growth. The innate GC sensitivity probably modifies these effects. Online address: http://www.molmed.org doi: 10.2119/molmed.2012.00261Ministry of Science and Technological Development of Serbia [III41009