Multi-Satellite Attitude Prediction program/Orbiting Solar Observatory-8 (MSAP/OSO-8) operating guide

The sun's lower corona and chromosphere and their interaction in the X-ray and ultraviolet (UV) spectral regions were investigated to better understand the transport of energy from the photosphere to the corona. The interaction between the solar electromagnetic and particle radiation and the earth's environment was studied and the background component of cosmic X-rays was discussed

The Berry-Keating Hamiltonian and the Local Riemann Hypothesis

The local Riemann hypothesis states that the zeros of the Mellin transform of a harmonic-oscillator eigenfunction (on a real or p-adic configuration space) have real part 1/2. For the real case, we show that the imaginary parts of these zeros are the eigenvalues of the Berry-Keating hamiltonian H=(xp+px)/2 projected onto the subspace of oscillator eigenfunctions of lower level. This gives a spectral proof of the local Riemann hypothesis for the reals, in the spirit of the Hilbert-Polya conjecture. The p-adic case is also discussed.Comment: 9 pages, no figures; v2 included more mathematical background, v3 has minor edits for clarit

Modelling gravity on a hyper-cubic lattice

We present an elegant and simple dynamical model of symmetric, non-degenerate (n x n) matrices of fixed signature defined on a n-dimensional hyper-cubic lattice with nearest-neighbor interactions. We show how this model is related to General Relativity, and discuss multiple ways in which it can be useful for studying gravity, both classical and quantum. In particular, we show that the dynamics of the model when all matrices are close to the identity corresponds exactly to a finite-difference discretization of weak-field gravity in harmonic gauge. We also show that the action which defines the full dynamics of the model corresponds to the Einstein-Hilbert action to leading order in the lattice spacing, and use this observation to define a lattice analogue of the Ricci scalar and Einstein tensor. Finally, we perform a mean-field analysis of the statistical mechanics of this model.Comment: 5 page

Koszul binomial edge ideals

It is shown that if the binomial edge ideal of a graph $G$ defines a Koszul algebra, then $G$ must be chordal and claw free. A converse of this statement is proved for a class of chordal and claw free graphs

Plant canopy shape and the influences on UV exposures to the canopy

The solar spectra at selected sites over hemispherical, conical and pinnacle plant canopy models has been evaluated with a dosimetric technique. The irradiance at the sites varies by up to a factor of 0.31 compared to the irradiance on a horizontal plane. The biologically effective (UVBE) exposures evaluated with the dosimetric technique at sites over the plant canopy are up to 19% of that on a horizontal plane. Compared to a spectroradiometer, the technique provides a more practicable method of measuring the UVBE exposures at multiple sites over a plant canopy. Usage of a dosimeter at one site to provide the exposures at that site for different sun angles introduces an error of more than 50%. Knowledge of the spectra allowed the UV and UVBE exposures to be calculated at each site along with the exposures to the entire canopies. These were dependent on the sun angle and the canopy shape. For plant damage, the UVBE was a maximum of about 1.4 mJ cm-2/min. Compared to the hemispherical canopy, the UVBE exposure for generalised plant damage was 45% less for the pinnacle canopy and 23% less for the conical canopy. The canopy exposures could not be determined from measurements of the ambient exposure

The Anatomy of Memory Politics: A Formalist Analysis of Tate Britain’s ‘Artist and Empire’ and the Struggle over Britain’s Imperial Past

In this paper, I propose a new approach for understanding the meaning of memory politics, which draws upon the archetypal literary criticism of Northrop Frye. I suggest that the four archetypes elaborated by Frye—comedy, romance, tragedy, and satire—can be used as a heuristic device for interpreting the contested historical narratives that are associated with the politics of memory. I illustrate this approach through a case-study of Artists and Empire: Facing Britain’s Imperial Past, an exhibition held at Tate Britain in 2016, amidst increasing contestation over the meaning of the British Empire. In sum, I find that the exhibit narrated Britain’s imperial past as a comedy, in which a key theme was the progressive cultural mixing of the British and the people they colonized. To conclude, I discuss the implications of such a narrative for constructing an inclusive, postcolonial British identity. As an alternative, I draw on Aristotle to suggest that a tragic narrative would have been more propitious

Power-Law Distributions in a Two-sided Market and Net Neutrality

"Net neutrality" often refers to the policy dictating that an Internet service provider (ISP) cannot charge content providers (CPs) for delivering their content to consumers. Many past quantitative models designed to determine whether net neutrality is a good idea have been rather equivocal in their conclusions. Here we propose a very simple two-sided market model, in which the types of the consumers and the CPs are {\em power-law distributed} --- a kind of distribution known to often arise precisely in connection with Internet-related phenomena. We derive mostly analytical, closed-form results for several regimes: (a) Net neutrality, (b) social optimum, (c) maximum revenue by the ISP, or (d) maximum ISP revenue under quality differentiation. One unexpected conclusion is that (a) and (b) will differ significantly, unless average CP productivity is very high

Formal Hecke algebras and algebraic oriented cohomology theories

In the present paper we generalize the construction of the nil Hecke ring of Kostant-Kumar to the context of an arbitrary algebraic oriented cohomology theory of Levine-Morel and Panin-Smirnov, e.g. to Chow groups, Grothendieck's K_0, connective K-theory, elliptic cohomology, and algebraic cobordism. The resulting object, which we call a formal (affine) Demazure algebra, is parameterized by a one-dimensional commutative formal group law and has the following important property: specialization to the additive and multiplicative periodic formal group laws yields completions of the nil Hecke and the 0-Hecke rings respectively. We also introduce a deformed version of the formal (affine) Demazure algebra, which we call a formal (affine) Hecke algebra. We show that the specialization of the formal (affine) Hecke algebra to the additive and multiplicative periodic formal group laws gives completions of the degenerate (affine) Hecke algebra and the usual (affine) Hecke algebra respectively. We show that all formal affine Demazure algebras (and all formal affine Hecke algebras) become isomorphic over certain coefficient rings, proving an analogue of a result of Lusztig.Comment: 28 pages. v2: Some results strengthened and references added. v3: Minor corrections, section numbering changed to match published version. v4: Sign errors in Proposition 6.8(d) corrected. This version incorporates an erratum to the published versio

Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat

INTRODUCTION: Of the more than one million global cases of breast cancer diagnosed each year, approximately fifteen percent are characterized as triple-negative, lacking the estrogen, progesterone, and Her2/neu receptors. Lack of effective therapies, younger age at onset, and early metastatic spread have contributed to the poor prognoses and outcomes associated with these malignancies. Here, we investigate the ability of the histone deacetylase inhibitor panobinostat (LBH589) to selectively target triple-negative breast cancer (TNBC) cell proliferation and survival in vitro and tumorigenesis in vivo. METHODS: TNBC cell lines MDA-MB-157, MDA-MB-231, MDA-MB-468, and BT-549 were treated with nanomolar (nM) quantities of panobinostat. Relevant histone acetylation was verified by flow cytometry and immunofluorescent imaging. Assays for trypan blue viability, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) proliferation, and DNA fragmentation were used to evaluate overall cellular toxicity. Changes in cell cycle progression were assessed with propidium iodide flow cytometry. Additionally, qPCR arrays were used to probe MDA-MB-231 cells for panobinostat-induced changes in cancer biomarkers and signaling pathways. Orthotopic MDA-MB-231 and BT-549 mouse xenograft models were used to assess the effects of panobinostat on tumorigenesis. Lastly, flow cytometry, ELISA, and immunohistochemical staining were applied to detect changes in cadherin-1, E-cadherin (CDH1) protein expression and the results paired with confocal microscopy in order to examine changes in cell morphology. RESULTS: Panobinostat treatment increased histone acetylation, decreased cell proliferation and survival, and blocked cell cycle progression at G2/M with a concurrent decrease in S phase in all TNBC cell lines. Treatment also resulted in apoptosis induction at 24 hours in all lines except the MDA-MB-468 cell line. MDA-MB-231 and BT-549 tumor formation was significantly inhibited by panobinostat (10 mg/kg/day) in mice. Additionally, panobinostat up-regulated CDH1 protein in vitro and in vivo and induced cell morphology changes in MDA-MB-231 cells consistent with reversal of the mesenchymal phenotype. CONCLUSIONS: This study revealed that panobinostat is overtly toxic to TNBC cells in vitro and decreases tumorigenesis in vivo. Additionally, treatment up-regulated anti-proliferative, tumor suppressor, and epithelial marker genes in MDA-MB-231 cells and initiated a partial reversal of the epithelial-to-mesenchymal transition. Our results demonstrate a potential therapeutic role of panobinostat in targeting aggressive triple-negative breast cancer cell types