The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy : a systematic review and economic evaluation

Peer reviewedPublisher PD

Is self-monitoring an effective option for people receiving long-term vitamin K antagonist therapy? A systematic review and economic evaluation

OBJECTIVES: To investigate the clinical and cost-effectiveness of self-monitoring of coagulation status in people receiving long-term vitamin K antagonist therapy compared with standard clinic care. DESIGN: Systematic review of current evidence and economic modelling. DATA SOURCES: Major electronic databases were searched up to May 2013. The economic model parameters were derived from the clinical effectiveness review, routine sources of cost data and advice from clinical experts. STUDY ELIGIBILITY CRITERIA: Randomised controlled trials (RCTs) comparing self-monitoring versus standard clinical care in people with different clinical conditions. Self-monitoring included both self-management (patients conducted the tests and adjusted their treatment according to an algorithm) and self-testing (patients conducted the tests, but received treatment recommendations from a clinician). Various point-of-care coagulometers were considered. RESULTS: 26 RCTs (8763 participants) were included. Both self-management and self-testing were as safe as standard care in terms of major bleeding events (RR 1.08, 95% CI 0.81 to 1.45, p=0.690, and RR 0.99, 95% CI 0.80 to 1.23, p=0.92, respectively). Self-management was associated with fewer thromboembolic events (RR 0.51, 95% CI 0.37 to 0.69, p </= 0.001) and with a borderline significant reduction in all-cause mortality (RR 0.68, 95% CI 0.46 to 1.01, p=0.06) than standard care. Self-testing resulted in a modest increase in time in therapeutic range compared with standard care (weighted mean difference, WMD 4.4%, 95% CI 1.71 to 7.18, p=0.02). Total health and social care costs over 10 years were pound7324 with standard care and pound7326 with self-monitoring (estimated quality adjusted life year, QALY gain was 0.028). Self-monitoring was found to have approximately 80% probability of being cost-effective compared with standard care applying a ceiling willingness-to-pay threshold of pound20,000 per QALY gained. Within the base case model, applying the pooled relative effect of thromboembolic events, self-management alone was highly cost-effective while self-testing was not. CONCLUSIONS: Self-monitoring appears to be a safe and cost-effective option. TRIAL REGISTRATION NUMBER: PROSPERO CRD42013004944

Role of the Nuclear and Electromagnetic Interactions in the Coherent Dissociation of the Relativistic 7^7Li Nucleus into the 3^3H + 4^4He Channel

The differential cross section in the transverse momentum $Q$ and a total cross section of $(31\pm4)$ mb for the coherent dissociation of a 3-A-GeV/$c$ $^7$Li nucleus through the $^3$H$+^4$He channel have been measured on emulsion nuclei. The observed $Q$ dependence of the cross section is explained by the predominant supposition of the nuclear diffraction patterns on light (C, N, O) and heavy (Br, Ag) emulsion nuclei. The contributions to the cross section from nuclear diffraction ($Q\le400$ MeV/$c$) and Coulomb $(Q\le50$ MeV/$c$) dissociations are calculated to be 40.7 and 4 mb, respectively.Comment: ISSN 0021-3640, Pleiades Publishing, Ltd., 200

On the Relativistic Description of the Nucleus

We discuss a relativistic theory of the atomic nuclei in the framework of the hamiltonian formalism and of the mesonic model of the nucleus. Attention is paid to the translational invariance of the theory. Our approach is centered on the concept of spectral amplitude, a function in the Dirac spinor space. We derive a Lorentz covariant equation for the latter, which requires as an input the baryon self-energy. For this we either postulate the most general Lorentz-Poincar\'e invariant expression or perform a calculation via a Bethe-Salpeter equation starting from a nucleon-nucleus interaction. We discuss the features of the nuclear spectrum obtained in the first instance. Finally the general constraints the self-energy should satisfy because of analyticity and Poincar\'e covariance are discussed

The Particle-Vibration Coupling Form Factor

peer reviewe

Effects of Short Range Correlations on Ca Isotopes

The effect of Short Range Correlations (SRC) on Ca isotopes is studied using a simple phenomenological model. Theoretical expressions for the charge (proton) form factors, densities and moments of Ca nuclei are derived. The role of SRC in reproducing the empirical data for the charge density differences is examined. Their influence on the depletion of the nuclear Fermi surface is studied and the fractional occupation probabilities of the shell model orbits of Ca nuclei are calculated. The variation of SRC as function of the mass number is also discussed.Comment: 11 pages (RevTex), 6 Postscript figures available upon request at [email protected] Physical Review C in prin

Systematic study of the effect of short range correlations on the form factors and densities of s-p and s-d shell nuclei

Analytical expressions of the one- and two-body terms in the cluster expansion of the charge form factors and densities of the s-p and s-d shell nuclei with N=Z are derived. They depend on the harmonic oscillator parameter b and the parameter $\beta$ which originates from the Jastrow correlation function. These expressions are used for the systematic study of the effect of short range correlations on the form factors and densities and of the mass dependence of the parameters b and $\beta$. These parameters have been determined by fit to the experimental charge form factors. The inclusion of the correlations reproduces the experimental charge form factors at the high momentum transfers ($q\geq 2 1/fm$). It is found that while the parameter $\beta$ is almost constant for the closed shell nuclei, $^4$He, $^{16}$O and $^{40}$Ca, its values are larger (less correlated systems) for the open shell nuclei, indicating a shell effect in the closed shell nuclei.Comment: Latex, 21 pages, 6 figures, 1 tabl

Microscopic theories of neutrino-^{12}C reactions

In view of the recent experiments on neutrino oscillations performed by the LSND and KARMEN collaborations as well as of future experiments, we present new theoretical results of the flux averaged $^{12}C(\nu_e,e^-)^{12}N$ and $^{12}C(\nu_{\mu},{\mu}^-)^{12}N$ cross sections. The approaches used are charge-exchange RPA, charge-exchange RPA among quasi-particles (QRPA) and the Shell Model. With a large-scale shell model calculation the exclusive cross sections are in nice agreement with the experimental values for both reactions. The inclusive cross section for $\nu_{\mu}$ coming from the decay-in-flight of $\pi^+$ is $15.2 \times 10^{-40} cm^2$ to be compared to the experimental value of $12.4 \pm 0.3 \pm 1.8 \times 10^{-40} cm^2$, while the one due to $\nu_{e}$ coming from the decay-at-rest of $\mu^+$ is $16.4 \times 10^{-42} cm^2$ which agrees within experimental error bars with the measured values. The shell model prediction for the decay-in-flight neutrino cross section is reduced compared to the RPA one. This is mainly due to the different kind of correlations taken into account in the calculation of the spin modes and partially due to the shell-model configuration basis which is not large enough, as we show using arguments based on sum-rules.Comment: 17 pages, latex, 5 figure