373 research outputs found
Photonic multipartite entanglement conversion using nonlocal operations
We propose a simple setup for the conversion of multipartite entangled states
in a quantum network with restricted access. The scheme uses nonlocal
operations to enable the preparation of states that are inequivalent under
local operations and classical communication, but most importantly does not
require full access to the states. It is based on a flexible linear optical
conversion gate that uses photons, which are ideally suited for distributed
quantum computation and quantum communication in extended networks. In order to
show the basic working principles of the gate, we focus on converting a
four-qubit entangled cluster state to other locally inequivalent four-qubit
states, such as the GHZ and symmetric Dicke state. We also show how the gate
can be incorporated into extended graph state networks, and can be used to
generate variable entanglement and quantum correlations without entanglement
but nonvanishing quantum discord.Comment: 10 pages, 6 figures, correction of reference list, add Journal ref.
and DO
Efficient decoherence-free entanglement distribution over lossy quantum channels
We propose and demonstrate a scheme for boosting up the efficiency of
entanglement distribution based on a decoherence-free subspace (DFS) over lossy
quantum channels. By using backward propagation of a coherent light, our scheme
achieves an entanglement-sharing rate that is proportional to the transmittance
T of the quantum channel in spite of encoding qubits in multipartite systems
for the DFS. We experimentally show that highly entangled states, which can
violate the Clauser-Horne-Shimony-Holt inequality, are distributed at a rate
proportional to T.Comment: 5pages, 5figure
Role of Energetic Electrons on Non-inductive Current Start-up and Formation of Inboard Poloidal Field Null Configuration in the Spherical Tokamak QUEST
Spatial and Velocity Space Measurement of Suprathermal Electrons to Study Non-inductive Plasma Current in QUEST
ING116070: a study of the pharmacokinetics and antiviral activity of dolutegravir in cerebrospinal fluid in HIV-1-infected, antiretroviral therapy-naive subjects.
BackgroundDolutegravir (DTG), a once-daily, human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and antiviral activity in cerebrospinal fluid (CSF).MethodsING116070 is an ongoing, single-arm, open-label, multicenter study in antiretroviral therapy-naive, HIV-1-infected adults. Subjects received DTG (50 mg) plus abacavir/lamivudine (600/300 mg) once daily. The CSF and plasma (total and unbound) DTG concentrations were measured at weeks 2 and 16. The HIV-1 RNA levels were measured in CSF at baseline and weeks 2 and 16 and in plasma at baseline and weeks 2, 4, 8, 12, and 16.ResultsThirteen white men enrolled in the study; 2 withdrew prematurely, 1 because of a non-drug-related serious adverse event (pharyngitis) and 1 because of lack of treatment efficacy. The median DTG concentrations in CSF were 18 ng/mL (range, 4-23 ng/mL) at week 2 and 13 ng/mL (4-18 ng/mL) at week 16. Ratios of DTG CSF to total plasma concentration were similar to the unbound fraction of DTG in plasma. Median changes from baseline in CSF (n = 11) and plasma (n = 12) HIV-1 RNA were -3.42 and -3.04 log10 copies/mL, respectively. Nine of 11 subjects (82%) had plasma and CSF HIV-1 RNA levels <50 copies/mL and 10 of 11 (91%) had CSF HIV-1 RNA levels <2 copies/mL at week 16.ConclusionsThe DTG concentrations in CSF were similar to unbound plasma concentrations and exceeded the in vitro 50% inhibitory concentration for wild-type HIV (0.2 ng/mL), suggesting that DTG achieves therapeutic concentrations in the central nervous system. The HIV-1 RNA reductions were similar in CSF and plasma. Clinical Trials Registration. NCT01499199
Study of Suprathermal Electron Behavior in Non-inductive Current Ramp Up Phase of QUEST Plasmas
Role of Energetic Electrons on Non-inductive Current Start-up and Formation of an Inboard Poloidal Field Null Configuration in the Spherical Tokamak QUEST
Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin
Small leucine-rich repeat proteoglycan (SLRP) proteins have an important role in the organization of the extracellular matrix, especially in the formation of collagen fibrils. However, the mechanism governing the shape of collagen fibrils is poorly understood. Here, we report that the protein Osteomodulin (OMD) of the SLRP family is a monomeric protein in solution that interacts with type-I collagen. This interaction is dominated by weak electrostatic forces employing negatively charged residues of OMD, in particular Glu284 and Glu303, and controlled by entropic factors. The protein OMD establishes a fast-binding equilibrium with collagen, where OMD may engage not only with individual collagen molecules, but also with the growing fibrils. This weak electrostatic interaction is carefully balanced so it modulates the shape of the fibrils without compromising their viability
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