374 research outputs found
Photonic multipartite entanglement conversion using nonlocal operations
We propose a simple setup for the conversion of multipartite entangled states
in a quantum network with restricted access. The scheme uses nonlocal
operations to enable the preparation of states that are inequivalent under
local operations and classical communication, but most importantly does not
require full access to the states. It is based on a flexible linear optical
conversion gate that uses photons, which are ideally suited for distributed
quantum computation and quantum communication in extended networks. In order to
show the basic working principles of the gate, we focus on converting a
four-qubit entangled cluster state to other locally inequivalent four-qubit
states, such as the GHZ and symmetric Dicke state. We also show how the gate
can be incorporated into extended graph state networks, and can be used to
generate variable entanglement and quantum correlations without entanglement
but nonvanishing quantum discord.Comment: 10 pages, 6 figures, correction of reference list, add Journal ref.
and DO
Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin
Small leucine-rich repeat proteoglycan (SLRP) proteins have an important role in the organization of the extracellular matrix, especially in the formation of collagen fibrils. However, the mechanism governing the shape of collagen fibrils is poorly understood. Here, we report that the protein Osteomodulin (OMD) of the SLRP family is a monomeric protein in solution that interacts with type-I collagen. This interaction is dominated by weak electrostatic forces employing negatively charged residues of OMD, in particular Glu284 and Glu303, and controlled by entropic factors. The protein OMD establishes a fast-binding equilibrium with collagen, where OMD may engage not only with individual collagen molecules, but also with the growing fibrils. This weak electrostatic interaction is carefully balanced so it modulates the shape of the fibrils without compromising their viability
Teleradiology as a Foundation for an Enterprise-wide Health Care Delivery System
An effective, integrated telemedicine system has been developed that allows (a) teleconsultation between local primary health care providers (primary care physicians and general radiologists) and remote imaging subspecialists and (b) active patient participation related to his or her medical condition and patient education. The initial stage of system development was a traditional teleradiology consultation service between general radiologists and specialists; this established system was expanded to include primary care physicians and patients. The system was developed by using a well-defined process model, resulting in three integrated modules: a patient module, a primary health care provider module, and a specialist module. A middle agent layer enables tailoring and customization of the modules for each specific user type. Implementation by using Java and the Common Object Request Broker Architecture standard facilitates platform independence and interoperability. The system supports (a) teleconsultation between a local primary health care provider and an imaging subspecialist regardless of geographic location and (b) patient education and online scheduling. The developed system can potentially form a foundation for an enterprise-wide health care delivery system. In such a system, the role of radiologist specialists is enhanced from that of a diagnostician to the management of a patient’s process of care
Active control of a plasmonic metamaterial for quantum state engineering
We experimentally demonstrate the active control of a plasmonic metamaterial
operating in the quantum regime. A two-dimensional metamaterial consisting of
unit cells made from gold nanorods is investigated. Using an external laser we
control the temperature of the metamaterial and carry out quantum process
tomography on single-photon polarization-encoded qubits sent through,
characterizing the metamaterial as a variable quantum channel. The overall
polarization response can be tuned by up to 33% for particular nanorod
dimensions. To explain the results, we develop a theoretical model and find
that the experimental results match the predicted behavior well. This work goes
beyond the use of simple passive quantum plasmonic systems and shows that
external control of plasmonic elements enables a flexible device that can be
used for quantum state engineering.Comment: 8 pages, 4 figure
PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity
INTRODUCTION:
Proline/arginine-rich end leucine-rich repeat protein (PRELP), is a small secreted proteoglycan expressed by pericytes and vascular smooth muscle cells surrounding the brain vasculature of adult mouse.
METHODS:
We utilised a Prelp knockout (Prelp−/−) mouse model to interrogate vasculature integrity in the brain alongside performing in vitro assays to characterise PRELP application to endothelial cells lines. Our findings were supplemented with RNA expression profiling to elucidate the mechanism of how PRELP maintains neurovasculature function.
RESULTS:
Prelp−/− mice presented with neuroinflammation and reducedneurovasculature integrity, resulting in IgG and dextran leakage in the cerebellum and cortex. Histological analysis of Prelp−/− mice revealed reducedcell-cell integrity of the blood brain barrier, capillary attachment of pericytes andastrocyte end-feet. RNA-sequencing analysis found that cell-cell adhesion andinflammation are affected in Prelp−/− mice and gene ontology analysis as well as gene set enrichment analysis demonstrated that inflammation related processes and adhesion related processes such as epithelial-mesenchymal transition and apical junctions were significantly affected, suggesting PRELP is a regulator of cell-cell adhesion. Immunofluorescence analysis showed that adhesion junction protein expression levels of cadherin, claudin-5, and ZO-1, was suppressed in Prelp−/− mice neurovasculature. Additionally, in vitro studies revealed that PRELP application to endothelial cells enhances cell-cell integrity, induces mesenchymal-endothelial transition and inhibits TGF-β mediated damage to cell-cell adhesion.
DISCUSSION:
Our study indicates that PRELP is a novel endogenous secreted regulator of neurovasculature integrity and that PRELP application may be a potential treatment for diseases associated with neurovascular damage
Sophisticated Framework between Cell Cycle Arrest and Apoptosis Induction Based on p53 Dynamics
The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis. However, it is not clear how p53 specifically regulates the implementation of these functions. By applying several well-known kinetic mathematical models, we constructed a novel model that described the influence that DNA damage has on the implementation of both the G2/M phase cell cycle arrest and the intrinsic apoptosis induction via its activation of the p53 synthesis process. The model, which consisted of 32 dependent variables and 115 kinetic parameters, was used to examine interference by DNA damage in the implementation of both G2/M phase cell cycle arrest and intrinsic apoptosis induction. A low DNA damage promoted slightly the synthesis of p53, which showed a sigmoidal behavior with time. In contrast, in the case of a high DNA damage, the p53 showed an oscillation behavior with time. Regardless of the DNA damage level, there were delays in the G2/M progression. The intrinsic apoptosis was only induced in situations where grave DNA damage produced an oscillation of p53. In addition, to wreck the equilibrium between Bcl-2 and Bax the induction of apoptosis required an extreme activation of p53 produced by the oscillation dynamics, and was only implemented after the release of the G2/M phase arrest. When the p53 oscillation is observed, there is possibility that the cell implements the apoptosis induction. Moreover, in contrast to the cell cycle arrest system, the apoptosis induction system is responsible for safeguarding the system that suppresses malignant transformations. The results of these experiments will be useful in the future for elucidating of the dominant factors that determine the cell fate such as normal cell cycles, cell cycle arrest and apoptosis
Path Selection for Quantum Repeater Networks
Quantum networks will support long-distance quantum key distribution (QKD)
and distributed quantum computation, and are an active area of both
experimental and theoretical research. Here, we present an analysis of
topologically complex networks of quantum repeaters composed of heterogeneous
links. Quantum networks have fundamental behavioral differences from classical
networks; the delicacy of quantum states makes a practical path selection
algorithm imperative, but classical notions of resource utilization are not
directly applicable, rendering known path selection mechanisms inadequate. To
adapt Dijkstra's algorithm for quantum repeater networks that generate
entangled Bell pairs, we quantify the key differences and define a link cost
metric, seconds per Bell pair of a particular fidelity, where a single Bell
pair is the resource consumed to perform one quantum teleportation. Simulations
that include both the physical interactions and the extensive classical
messaging confirm that Dijkstra's algorithm works well in a quantum context.
Simulating about three hundred heterogeneous paths, comparing our path cost and
the total work along the path gives a coefficient of determination of 0.88 or
better.Comment: 12 pages, 8 figure
Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy
© 2019 Commonwealth of Australia, Australian Nuclear Science and Technology Organisation, ANSTO.. The distribution of fragmentation products predicted by Monte Carlo simulations of heavy ion therapy depend on the hadronic physics model chosen in the simulation. This work aims to evaluate three alternative hadronic inelastic fragmentation physics options available in the Geant4 Monte Carlo radiation physics simulation framework to determine which model most accurately predicts the production of positron-emitting fragmentation products observable using in-beam PET imaging. Fragment distributions obtained with the BIC, QMD, and INCL + + physics models in Geant4 version 10.2.p03 are compared to experimental data obtained at the HIMAC heavy-ion treatment facility at NIRS in Chiba, Japan. For both simulations and experiments, monoenergetic beams are applied to three different block phantoms composed of gelatin, poly(methyl methacrylate) and polyethylene. The yields of the positron-emitting nuclei 11C, 10C and 15O obtained from simulations conducted with each model are compared to the experimental yields estimated by fitting a multi-exponential radioactive decay model to dynamic PET images using the normalised mean square error metric in the entrance, build up/Bragg peak and tail regions. Significant differences in positron-emitting fragment yield are observed among the three physics models with the best overall fit to experimental 12C and 16O beam measurements obtained with the BIC physics model
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