TRIS I: Absolute Measurements of the Sky Brightness Temperature at 0.6, 0.82 and 2.5 GHz

At frequencies close to 1 GHz the sky diffuse radiation is a superposition of radiation of Galactic origin, the 3 K Relic or Cosmic Microwave Background Radiation, and the signal produced by unresolved extragalactic sources. Because of their different origin and space distribution the relative importance of the three components varies with frequency and depends on the direction of observation. With the aim of disentangling the components we built TRIS, a system of three radiometers, and studied the temperature of the sky at $\nu =0.6$, $\nu = 0.82$ and $\nu = 2.5$ GHz using geometrically scaled antennas with identical beams (HPBW = $18^{\circ} \times 23^{\circ}$). Observations included drift scans along a circle at constant declination $\delta=+42^{\circ}$ which provided the dependence of the sky signal on the Right Ascension, and absolute measurement of the sky temperature at selected points along the same scan circle. TRIS was installed at Campo Imperatore (lat. = $42^{\circ}~26'$ N, long.= $13^{\circ}~33'$, elevation = 2000 m a.s.l.) in Central Italy, close to the Gran Sasso Laboratory.Comment: Accepted for publication in The Astrophysical Journa

Blue toe syndrome: A challenging diagnosis

\u201cBlue toe syndrome\u201d (BTS) refers to the acute onset of purple painful digits in the absence of evident trauma, cold-associated injury or disorders that induce generalized cyanosis. The term was used for the first time in 1976 by Komody, who underlined the vascular etiology of the disease and its possible diagnostic confirmation through angiography.[1,2] Indeed, BTS may occur from end-arterial occlusion, impaired venous outflow, and/or abnormal blood circulation. Peripheral microembolism with distal arterial occlusion is one of the most frequent underlying mechanisms of the disease and consists of disrupted material from ulcerated atheromatous plaques (atheromatous or cholesterol crystal emboli). The case described by us assumes significance because of an atypical clinical presentation of a peripheral embolism from an abdominal aortic aneurysm, hence necessitating a high index of suspicion to achieve the correct diagnosis.

TRIS III: the diffuse galactic radio emission at δ=+42∘\delta=+42^{\circ}

We present values of temperature and spectral index of the galactic diffuse radiation measured at 600 and 820 MHz along a 24 hours right ascension circle at declination $\delta = +42^{\circ}$. They have been obtained from a subset of absolute measurements of the sky temperature made with TRIS, an experiment devoted to the measurement of the Cosmic Microwave Background temperature at decimetric-wavelengths with an angular resolution of about $20^{\circ}$. Our analysis confirms the preexisting picture of the galactic diffuse emission at decimetric wavelength and improves the accuracy of the measurable quantities. In particular, the signal coming from the halo has a spectral index in the range $2.9-3.1$ above 600 MHz, depending on the sky position. In the disk, at TRIS angular resolution, the free-free emission accounts for the 11% of the overall signal at 600 MHz and 21% at 1420 MHz. The polarized component of the galactic emission, evaluated from the survey by Brouw and Spoelstra, affects the observations at TRIS angular resolution by less than 3% at 820 MHz and less than 2% at 600 MHz. Within the uncertainties, our determination of the galactic spectral index is practically unaffected by the correction for polarization. Since the overall error budget of the sky temperatures measured by TRIS at 600 MHz, that is 66 mK(systematic)$+$18 mK (statistical), is definitely smaller than those reported in previous measurements at the same frequency, our data have been used to discuss the zero levels of the sky maps at 150, 408, 820 and 1420 MHz in literature. Concerning the 408 MHz survey, limiting our attention to the patch of sky corresponding to the region observed by TRIS, we suggest a correction of the base-level of $(+3.9\pm 0.6)$K.Comment: Accepted for publication in the Astrophysical Journa

Preliminary Estimation of Black Carbon Deposition from Nepal Climate Observatory-Pyramid Data and Its Possible Impact on Snow Albedo Changes Over Himalayan Glaciers During the Pre-Monsoon Season

The possible minimal range of reduction in snow surface albedo due to dry deposition of black carbon (BC) in the pre-monsoon period (March-May) was estimated as a lower bound together with the estimation of its accuracy, based on atmospheric observations at the Nepal Climate Observatory-Pyramid (NCO-P) sited at 5079 m a.s.l. in the Himalayan region. We estimated a total BC deposition rate of 2.89 g m-2 day-1 providing a total deposition of 266 micrograms/ square m for March-May at the site, based on a calculation with a minimal deposition velocity of 1.0 10(exp -4) m/s with atmospheric data of equivalent BC concentration. Main BC size at NCO-P site was determined as 103.1-669.8 nm by correlation analysis between equivalent BC concentration and particulate size distribution in the atmosphere. We also estimated BC deposition from the size distribution data and found that 8.7% of the estimated dry deposition corresponds to the estimated BC deposition from equivalent BC concentration data. If all the BC is deposited uniformly on the top 2-cm pure snow, the corresponding BC concentration is 26.0-68.2 microgram/kg assuming snow density variations of 195-512 kg/ cubic m of Yala Glacier close to NCO-P site. Such a concentration of BC in snow could result in 2.0-5.2% albedo reductions. From a simple numerical calculations and if assuming these albedo reductions continue throughout the year, this would lead to a runoff increases of 70-204 mm of water drainage equivalent of 11.6-33.9% of the annual discharge of a typical Tibetan glacier. Our estimates of BC concentration in snow surface for pre-monsoon season can be considered comparable to those at similar altitude in the Himalayan region, where glaciers and perpetual snow region starts in the vicinity of NCO-P. Our estimates from only BC are likely to represent a lower bound for snow albedo reductions, since a fixed slower deposition velocity was used and atmospheric wind and turbulence effects, snow aging, dust deposition, and snow albedo feedbacks were not considered. This study represents the first investigation about BC deposition on snow from atmospheric aerosol data in Himalayas and related albedo effect is especially the first track at the southern slope of Himalayas

ARCADE 2 Observations of Galactic Radio Emission

We use absolutely calibrated data from the ARCADE 2 flight in July 2006 to model Galactic emission at frequencies 3, 8, and 10 GHz. The spatial structure in the data is consistent with a superposition of free-free and synchrotron emission. Emission with spatial morphology traced by the Haslam 408 MHz survey has spectral index beta_synch = -2.5 +/- 0.1, with free-free emission contributing 0.10 +/- 0.01 of the total Galactic plane emission in the lowest ARCADE 2 band at 3.15 GHz. We estimate the total Galactic emission toward the polar caps using either a simple plane-parallel model with csc|b| dependence or a model of high-latitude radio emission traced by the COBE/FIRAS map of CII emission. Both methods are consistent with a single power-law over the frequency range 22 MHz to 10 GHz, with total Galactic emission towards the north polar cap T_Gal = 0.498 +/- 0.028 K and spectral index beta = -2.55 +/- 0.03 at reference frequency 1 GHz. The well calibrated ARCADE 2 maps provide a new test for spinning dust emission, based on the integrated intensity of emission from the Galactic plane instead of cross-correlations with the thermal dust spatial morphology. The Galactic plane intensity measured by ARCADE 2 is fainter than predicted by models without spinning dust, and is consistent with spinning dust contributing 0.4 +/- 0.1 of the Galactic plane emission at 22 GHz.Comment: 10 poges, 9 figures. Submitted to The Astrophysical Journa

Influence of root maturity or periodontal involvement on dentinal collagen changes following NaOCL irrigation: an ex-vivo study

Abstract Aims: To refine FTIR protocol for detection of NaOCl-induced dentinal collagen changes using an ex- vivo irrigation model, and to apply it to determine the collagen change within 0.5mm of canal or root surfaces, with or without mature roots or periodontal involvement. Methodology: Extracted human roots were irrigated with control saline (n=3) or 5% NaOCl (n=3) and sectioned into transverse discs for FTIR analyses, 0.5mm from both the canal lumen and root surface, before and after surface-treatment with 17% EDTA. Amide I/phosphate and amide II/phosphate absorbance ratios were compared using the Wilcoxon sign rank test. Mature roots without periodontal involvement were irrigated with: saline (n=7), 5% NaOCl (n=7), or 5% NaOCl+17% EDTA (n=7); those with periodontal involvement (n=7) or immature roots (n=7) were irrigated with 5% NaOCl. Dentine discs were then prepared for FTIR analyses. The effects of irrigant/root-maturity/periodontal involvement were analysed using linear mixed models. Results: FTIR analyses of the irrigated samples revealed significant (P < 0.05) reduction in collagen bands near the canal lumen after NaOCl irrigation using surface-EDTA treated samples. Irrigation with test solutions resulted in significant (P < 0.0001) dentinal collagen changes in the mature roots, whilst those in the immature roots were significantly (P < 0.05) greater compared with the mature roots with or without periodontal involvement; but there were no difference between the latter groups. Conclusion: EDTA surface-treatment of polished dentine surfaces enhanced FTIR detection of NaOCl-induced collagen changes. Both root maturity and irrigation protocol influenced the ability of NaOCl to alter dentinal collagen up to 0.5mm from the canal lumen

Febrile Neutropenia Duration Is Associated with the Severity of Gut Microbiota Dysbiosis in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients

Febrile neutropenia (FN) is a common complication in pediatric patients receiving al-logeneic hematopoietic stem cell transplantation (HSCT). Frequently, a precise cause cannot be identified, and many factors can contribute to its genesis. Gut microbiota (GM) has been recently linked to many transplant-related complications, and may also play a role in the pathogenesis of FN. Here, we conducted a longitudinal study in pediatric patients receiving HSCT from three centers in Europe profiling their GM during the transplant course, particularly at FN onset. We found that a more stable GM configuration over time is associated with a shorter duration of fever. Moreover, patients with longer lasting fever exhibited higher pre-HSCT levels of Collinsella, Megasphaera, Prevotella and Roseburia and increased proportions of Eggerthella and Akkermansia at the engraftment. These results suggest a possible association of the GM with the genesis and course of FN. Data seem consistent with previous reports on the relationship of a so-called “healthy” GM and the reduction of transplant complications. To our knowledge, this is the first report in the pediatric HSCT setting. Future studies are warranted to define the underling biological mechanisms and possible clinical implications

The contribution of the Unresolved Extragalactic Radio Sources to the Brightness Temperature of the sky

The contribution of the Unresolved Extragalactic Radio Sources to the diffuse brightness of the sky was evaluated using the source number - flux measurements available in literature. We first optimized the fitting function of the data based on number counts distribution. We then computed the brightness temperature at various frequencies from 151 MHz to 8440 MHz and derived its spectral dependence. As expected the frequency dependence can be described by a power law with a spectral index $\gamma \simeq -2.7$, in agreement with the flux emitted by the {\it steep spectrum} sources. The contribution of {\it flat spectrum} sources becomes relevant at frequencies above several GHz. Using the data available in literature we improved our knowledge of the brightness of the unresolved extragalactic radio sources. The results obtained have general validity and they can be used to disentangle the various contributions of the sky brightness and to evaluate the CMB temperature.Comment: Accepted for publication in the Astrophysical Journa

Risk response strategies for collaborative university-industry R&D funded programs

Universities are centers of knowledge in our societies and their role when it comes to innovation has become more important over the years. Companies have several reasons to engage in research collaborations with universities, namely to gain access to innovative technologies. University-Industry R&D collaborations are expected to play an important role in regional economies, and to fulfill the industry’s demand for innovative products, technologies and processes. However, the knowledge on what are the potential risks resulting from these collaborations and the risk response strategies to reduce the negative risk impacts and to enhance positive risk impacts is still limited. Thus, this paper aims to fill the gap in literature when it comes to risk identification and risk responses’ planning, by identifying, based on a case study analysis, 19 potential risks and 53 potential risk response strategies.INCT-EN - Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção(SFRH/BPD/111033/2015

Spectral Distortions of the CMB as a Probe of Inflation, Recombination, Structure Formation and Particle Physics

Following the pioneering observations with COBE in the early 1990s, studies of the cosmic microwave background (CMB) have focused on temperature and polarization anisotropies. CMB spectral distortions - tiny departures of the CMB energy spectrum from that of a perfect blackbody - provide a second, independent probe of fundamental physics, with a reach deep into the primordial Universe. The theoretical foundation of spectral distortions has seen major advances in recent years, which highlight the immense potential of this emerging field. Spectral distortions probe a fundamental property of the Universe - its thermal history - thereby providing additional insight into processes within the cosmological standard model (CSM) as well as new physics beyond. Spectral distortions are an important tool for understanding inflation and the nature of dark matter. They shed new light on the physics of recombination and reionization, both prominent stages in the evolution of our Universe, and furnish critical information on baryonic feedback processes, in addition to probing primordial correlation functions at scales inaccessible to other tracers. In principle the range of signals is vast: many orders of magnitude of discovery space could be explored by detailed observations of the CMB energy spectrum. Several CSM signals are predicted and provide clear experimental targets, some of which are already observable with present-day technology. Confirmation of these signals would extend the reach of the CSM by orders of magnitude in physical scale as the Universe evolves from the initial stages to its present form. The absence of these signals would pose a huge theoretical challenge, immediately pointing to new physics.Comment: Astro2020 Science White Paper, 5 pages text, 13 pages in total, 3 Figures, minor update to reference