Thinking Outside The Box : The Potential of Management Training for Reducing Turnover in Warehouse/Distribution Environments

Avoidable turnover is a costly issue for firms, particularly in the warehousing industry. Retaining workers is an important priority which allows firms to meet complex and demanding customer service requirements. Distribution tasks such as order processing and fulfillment are highly labor intensive and further add to the cost of turnover. Increasing order volumes also tax firms operating within a growing e-commerce economy. A sustainable solution is needed for the avoidable turnover problem in such firms. By encouraging management development programs for first line managers through coaching it is expected that the avoidable turnover rates can be reduced effectively. The theory of human resource devolution links strategic policy to employee practices by using line managers as HR implementers. Through the targeted training of line managers firms will be able to reach more of their low-level employees, increasing job embedment, job satisfaction, organizational commitment, and eventually retention rates. Several cases studies are reviewed, consisting of exploratory research on management training in warehouses as well as the barriers that improved human resource devolution currently faces. An applied case study from the Mayo Clinic is also referenced, concerning the implementation of a management training program in response to the high turnover rate of its medical staff. The literature review acknowledges the relatively new nature of its topic. Further research can be done, especially in the warehousing sector where there is both the potential for additional scholarship and a financial need to find cost effective solutions to the problem. Keywords: warehouse, first line manager, management coaching, training, development, turnover, retention, distribution, logistics, HR devolution, management training program, avoidable turnover, leader member exchange, Attraction Selection Attrition Framework, strategic human resources, leadershi

Peer interaction in text chat: Qualitative analysis of chat transcripts

Prior research has shown that intermediate-level adult learners of Russian who worked interactively with partners using text chat improved their vocabulary and oral production skills more than students who worked independently (Tare et al., 2014). Drawing on the dataset from Tare et al. (2014), the current study follows up to explore the nature of the students’ (N = 25) interactions during the text chat activities to determine potential sources of the gains. All 18 activities developed for the study encouraged interaction to complete tasks in pairs. A detailed coding of 169 text chat transcripts examined instances of peer–peer interactions. Our quantitative and qualitative analyses explored whether and to what extent real-time interactive language tasks foster the kinds of language-related moves that may support greater language learning. Results show that students spontaneously engaged in various behaviors which may support language learning, such as providing language-related assistance (self- and peer-correction, negotiation for meaning), using their partner as a resource (for clarifying information, modeling language use, or helping with unknown vocabulary), and providing encouragement (responding positively to the task and to each other, eliciting information from a partner). The most frequent instances were of positive affect, self-correction, and partner correction

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes

HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 and directly regulates osteoblastic phenotypic genes. In response to bone morphogenic protein BMP2, Hoxa10 is rapidly induced and functions to activate the Runx2 transcription factor essential for bone formation. A functional element with the Hox core motif was characterized for the bone-related Runx2 P1 promoter. HOXA10 also activates other osteogenic genes, including the alkaline phosphatase, osteocalcin, and bone sialoprotein genes, and temporally associates with these target gene promoters during stages of osteoblast differentiation prior to the recruitment of RUNX2. Exogenous expression and small interfering RNA knockdown studies establish that HOXA10 mediates chromatin hyperacetylation and trimethyl histone K4 (H3K4) methylation of these genes, correlating to active transcription. HOXA10 therefore contributes to early expression of osteogenic genes through chromatin remodeling. Importantly, HOXA10 can induce osteoblast genes in Runx2 null cells, providing evidence for a direct role in mediating osteoblast differentiation independent of RUNX2. We propose that HOXA10 activates RUNX2 in mesenchymal cells, contributing to the onset of osteogenesis, and that HOXA10 subsequently supports bone formation by direct regulation of osteoblast phenotypic genes. <br/

Dorsal Eye Selector Pannier (pnr) Suppresses the Eye Fate to Define Dorsal Margin of the Drosophila Eye

Axial patterning is crucial for organogenesis. During Drosophila eye development, dorso-ventral (DV) axis determination is the first lineage restriction event. The eye primordium begins with a default ventral fate, on which the dorsal eye fate is established by expression of the GATA-1 transcription factor pannier (pnr). Earlier, it was suggested that loss of pnr function induces enlargement in the dorsal eye due to ectopic equator formation. Interestingly, we found that in addition to regulating DV patterning, pnr suppresses the eye fate by downregulating the core retinal determination genes eyes absent (eya), sine oculis (so) and dacshund (dac) to define the dorsal eye margin. We found that pnr acts downstream of Ey and affect the retinal determination pathway by suppressing eya. Further analysis of the “eye suppression” function of pnr revealed that this function is likely mediated through suppression of the homeotic gene teashirt (tsh) and is independent of homothorax (hth), a negative regulator of eye. Pnr expression is restricted to the peripodial membrane on the dorsal eye margin, which gives rise to head structures around the eye, and pnr is not expressed in the eye disc proper that forms the retina. Thus, pnr has dual function, during early developmental stages pnr is involved in axial patterning whereas later it promotes the head specific fate. These studies will help in understanding the developmental regulation of boundary formation of the eye field on the dorsal eye margin

Drosophila Adult Eye Model to Teach Scanning Electron Microscopy in an Undergraduate Cell Biology Laboratory

We have devised an undergraduate laboratory exercise to study tissue morphology using fruit fly, Drosophila melanogaster, as the model organism. Drosophila can be reared in a cost effective manner in a short period of time. This experiment was a part of the undergraduate curriculum of the cell biology laboratory course aimed to demonstrate the use of scanning electron microscopy (SEM) technique to study the morphology of adult eye of Drosophila. The adult eye of Drosophila is a compound eye, which comprises of 800 unit eyes, and serves as an excellent model for SEM studies. We used flies that were mutant for lobe (L), eyeless (ey), and pannier (pnr) for our studies. The mutant flies exhibit different morphologies of the adult eye. We employed a modified protocol, which reduces sample preparation steps and makes it practically feasible to complete the protocol in assigned time for the cell biology laboratory. The idea of this laboratory exercise is to: (a) familiarize students with the underlying principles of scanning electron microscopy and its application to diverse areas of research, (b) to enable students to sharpen their observation and quantitative microscopy skills, and (c) minimize the preparation time for the instructor

Relationships of attitudes toward homework and time spent on homework to course outcomes: The case of foreign language learning

In previous studies of homework in core academic subjects, positive student attitudes toward homework were linked to higher achievement, whereas time spent on homework showed an inconsistent relationship with achievement. This study examined the generalizability of these findings to foreign language learning by analyzing 2,342 adult students' attitudes toward assigned homework, time spent on assigned homework, and achievement outcomes in a variety of foreign language courses. Student ratings of the relevance of homework, the usefulness of feedback provided on homework, and the fairness of homework grading were positively correlated with teacher-assigned grades and standardized proficiency test scores in listening, reading, and speaking. Reported time spent on homework, however, was negatively correlated with these measures. In hierarchical regression analyses, all homework-related variables emerged as significant predictors of outcomes after controlling for potential covariates such as language learning aptitude, demographic variables, and affective factors. Thus, these results provide evidence that language course outcomes are positively associated with attitudes toward homework but negatively associated with time spent on homework. Possible interpretations of these findings are discussed. We suggest that the negative association follows in part from the opportunity cost of time spent on assigned homework, which decreases time spent on individualized study that may be more beneficial for improving language course outcomes

Review Paper - High Utility Item sets Mining on Incremental Transactions using UP-Growth and UP-Growth+ Algorithm

One of the important research area in data mining is high utility pattern mining. Discovering itemsets with high utility like profit from database is known as high utility itemset mining. There are number of existing algorithms have been work on this issue. Some of them incurs problem of generating large number of candidate itemsets. This leads to degrade the performance of mining in case of execution time and space. In this paper we have focus on UP-Growth and UP-Growth+ algorithm which overcomes this limitation. This technique uses tree based data structure, UP-Tree for generating candidate itemsets with two scan of database. In this paper we extend the functionality of these algorithms on incremental database.

Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation

Background: A recent clinical trial (RELAXin in Acute Heart Failure [RELAX-AHF]) demonstrated that 48 hours of continuous intravenous infusion of the vasorelaxant peptide serelaxin (recombinant human relaxin-2) to patients with acute heart failure reduced cardiovascular mortality at 180 days. The persistence of a vasorelaxant response as a potential mechanism for this long-term benefit and the vascular effects of a bolus intravenous injection of serelaxin have not been examined. This study investigates changes in resistance artery reactivity and passive mechanical wall properties following an intravenous serelaxin injection and whether these vascular effects persist in the absence of detectable circulating serelaxin. Methods and Results: Male rats were injected with 13.3 μg/kg serelaxin into the tail vein; mesenteric arteries were assessed 3 and 24 hours after treatment by using wire-myography. Serelaxin increased basal nitric oxide synthase activity and reduced maximal contraction to endothelin-1 at 3 hours after administration. Serelaxin treatment also selectively enhanced bradykinin-mediated endothelium-dependent relaxation. This effect was sustained for 24 hours in the absence of circulating serelaxin. Serelaxin-mediated augmentation of bradykinin-evoked relaxation involved endothelium-derived hyperpolarization after 3 hours and prostacyclin-mediated relaxation after 24 hours. Furthermore, upregulation of inducible nitric oxide synthase, phosphorylation of protein kinase B at Ser473 and endothelial nitric oxide synthase at Ser1177 was observed at 24 hours after serelaxin injection. There were no effects of serelaxin on passive arterial wall stiffness. Conclusion: Our data show that a bolus intravenous injection of serelaxin modulates endothelial vasodilator function 3 hours after administration, an effect that was sustained for 24 hours. The prolonged bradykinin-mediated vasorelaxation is principally mediated through prostacyclin.Chen Huei Leo, Maria Jelinic, Helena C. Parkington, Marianne Tare, Laura J. Parr

Relaxin deficiency leads to uterine artery dysfunction during pregnancy in mice

The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy. We tested the hypothesis that relaxin deficiency increases myogenic tone and impairs endothelial vasodilator function in uterine arteries of late pregnant relaxin deficient (Rln−/−) mice. Reactivity of main uterine arteries from non-pregnant and late pregnant wild-type (Rln+/+) and Rln−/− mice was studied using pressure and wire myography and changes in gene expression explored using PCR. Myogenic tone was indistinguishable in arteries from non-pregnant mice. In late pregnancy uterine artery myogenic tone was halved in Rln+/+ mice (P < 0.0001), an adaptation that failed to occur in arteries from pregnant Rln−/− mice. The role of vasodilator prostanoids in the regulation of myogenic tone was significantly reduced in arteries of pregnant Rln−/− mice (P = 0.02). Agonist-mediated endothelium-dependent vasodilation was significantly impaired in non-pregnant Rln−/− mice. With pregnancy, differences in total endothelial vasodilator function were resolved, although there remained an underlying deficiency in the role of vasodilator prostanoids and alterations to the contributions of calcium-activated K+ channels. Fetuses of late pregnant Rln−/− mice were ~10% lighter (P < 0.001) than those of Rln+/+ mice. In conclusion, relaxin deficiency is associated with failed suppression of uterine artery myogenic tone in pregnancy, which likely contributes to reduced uteroplacental perfusion and fetal growth restriction.Sarah A. Marshall, Sevvandi N. Senadheera, Maria Jelinic, Kelly O’Sullivan, Laura J. Parry and Marianne Tar