Study on the Influence of CPAs’ Individual Characteristics on Integrity Conduct

By constructing a behaviour selection model, the paper relies on the method of NetLogo simulation for simulation experiments. We study the influence of CPA’s individual characteristics on integrity conduct from three aspects of independence, industry specialization and tenure. The results of the study found that independence, industry specialization and tenure will have an impact on the integrity conduct. Besides, with the improvement of independence, industry specialization and tenure, their integrity conduct presents an inverted U type

Quartz sand surface morphology of granitic tafoni at Laoshan, China

43-48In this study, a SEM method was used to analyze the surface morphology of the quartz sand granitic tafoni at Laoshan, for the purpose of exploring the weathering process of this tafoni. Present study showed that granitic tafoni at Laoshan, the quartz sand roundness was dominated by angular and sub-angular morphologies. Massive Hydrodynamic features had been developed on the quartz sand surfaces, as well as wind and chemistry forms, which were more developed. It was determined that granitic tafoni at Laoshan, the quartz sand had suffered long-term rainy and windy mechanical erosion, as well as chemical dissolution from residual pit water. These findings differed from the earlier views that the tafone was formed by the glacial melt water

Characteristics of buried paleo-channels in the Western South Yellow Sea during the Late Last Glaciation

Istraživanja o evoluciji paleolitskih korita u obalnim područjima važna su za konstrukcije podmorskog inženjerstva i za otkrivanje promjena u globalnom paleolitskom okruženju. Stoga je za istraživanje značajki paleo-korita tijekom kasnog posljednjeg ledenog doba u zapadnom Južnom Žutom moru primijenjena digitalna metoda analize terena i ArcGis funkcija porijekla rijeke, analizirani su plitki stratigrafski seizmički profili visoke rezolucije i osnovni podaci, a rabljene su empirijske formule rijeke za određivanje riječnih svojstava i struktura. Rezultati pokazuju da je drevni riječni sustav tijekom kasnog posljednjeg ledenog doba grebena Južnog Žutog mora podijeljen na paleo-Žutu (Huanghe) i paleo-Yangtze (Changjiang) rijeku. Paleo-korita blizu 33°N pripadaju paleo-Yangtze rijeci i uglavnom teku od istoka do sjeveroistoka. Paleo-korita oko 35°N i 123,5°E dio su paleo-Žute rijeke. U usporedbi s paleo-Žutom rijekom, paleo-Yangtze rijeka inklinira horizontalnom premiještanju, ima veću prodornu moć i veću količinu vode. Na temelju metode širine nagiba sustav paleo-Žute rijeke može se smatrati uglavnom krivudavim dok je sustav paleo-Yangtze rijeke uglavnom sustav račvaste (braided) rijeke. Pronađene su značajne razlike između paleo-Yangtze rijeke i paleo-Žute rijeke. Značajke podzemnih paleo-korita tijekom kasnog posljednjeg ledenog doba mogu biti korisne u predviđanju popratne moguće opasnosti kod podvodnih konstrukcija i otkrivanju promjena paleookruženja u grebenu Južnog Žutog mora.Studies on the evolution of paleo-channels in coastal areas are important for submarine engineering construction and to reveal changes in the global paleoenvironment. Thus, to explore the characteristics of paleo-channels during the late Last Glaciation in the western South Yellow Sea, digital terrain analysis method and ArcGis river extraction function were employed, high-resolution shallow stratigraphic seismic profiles and core data were analysed, and river empirical formulas were used to determine river properties and river patterns. Results indicate that the ancient river system during the late Last Glaciation of the South Yellow Sea shelf is divided into paleo-Yellow (Huanghe) and paleo-Yangtze (Changjiang) Rivers. The paleo-channels near 33°N belong to the paleo-Yangtze River, and generally flow from east to northeast. The paleo-channels around 35°N and 123,5°E are part of the paleo-Yellow River. Compared with the paleo-Yellow River, the paleo-Yangtze River is prone to horizontal migration and has higher penetration depths and discharge. Based on the slope-width method, the paleo-Yellow River system can be considered mainly as a meandering river, whereas the paleo-Yangtze River system is largely a braided river. Remarkable differences are found between the paleo-Yangtze River and the paleo-Yellow River. The characteristics of buried paleo-channels during the late Last Glaciation can be useful in predicting the incident potential hazard of submarine engineering and in revealing the paleoenvironment changes in the South Yellow Sea shelf

Rap2B promotes proliferation, migration and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway

Rap2B, a member of GTP-binding proteins, is widely upregulated in many types of tumors and promotes migration and invasion of human suprarenal epithelioma. However, the function of Rap2B in breast cancer is unknown. Expression of Rap2B was examined in breast cancer cell lines and human normal breast cell line using Western blot analysis. Using the CCK-8 cell proliferation assay, cell cycle analysis, and transwell migration assay, we also elucidated the role of Rap2B in breast cancer cell proliferation, migration, and invasion. Results showed that the expression of Rap2B is higher in tumor cells than in normal cells. Flow cytometry and Western blot analysis revealed that Rap2B elevates the intracellular calcium level and further promotes extracellular signal-related kinase (ERK) 1/2 phosphorylation. By contrast, calcium chelator BAPTM/AM and MEK inhibitor (U0126) can reverse Rap2B-induced ERK1/2 phosphorylation. Furthermore, Rap2B knockdown inhibits cell proliferation, migration, and invasion abilities via calcium related-ERK1/2 signaling. In addition, overexpression of Rap2B promotes cell proliferation, migration and invasion abilities, which could be neutralized by BAPTM/AM and U0126. Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer

Clinical application of a fully automated blood collection robot and its assessment of blood collection quality of anticoagulant specimens

Background and objectivesTo investigate the application of intelligent puncture blood collection robots in anticoagulated blood specimens, the satisfaction of subjects with the two blood collection methods, and the feasibility of intelligent blood collection devices to replace manual blood collection methods in clinical work.Materials and methodsA total of 154 volunteers from Zhongshan Hospital Fudan University were recruited to compare the test results of anticoagulant blood samples between blood collection robot and manual blood collection, a questionnaire was used to inquire about the volunteers’ feelings about the two blood collection methods; the blood collection data of 6,255 patients willing to use the robot for blood collection were collected to analyze the success rate of blood collection.ResultsThe blood collection robot is superior to manual specimen collection in terms of volume and pain of specimen collection, and the puncture success rate is 94.3%. The anticoagulated blood specimens collected by the robot had 11 indexes statistically different from the results of manual blood collection, but the differences did not affect the clinical diagnosis and prognosis.ConclusionThe intelligent robotic blood collection is less painful and has better acceptance by patients, which can be used for clinical anticoagulated blood specimen collection

From concept to action: a united, holistic and One Health approach to respond to the climate change crisis

It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided

Non-Standard Errors

In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants

Streaming media business strategies and audience-centered practices: a comparative study of Netflix and Tencent Video

This comparative study of streaming services in different cultural and economic contexts shows how they optimize the user experience by improving recommendation algorithms, upgrading infrastructure, and developing global services, in responding to the crisis of losing subscribers. We use analysis of industry documents to demonstrate how different approaches to streaming video business value user-generated data and reconstruction practices. There is already a similar trend among global streaming platforms to create a pan-media entertainment & cultural service by increasing revenue streams and merchandise offering categories, as well as keeping subscriptions and attracting more viewers in the long run. The study displays how streaming platforms with SVOD, AVOD, and Mix-funded modes are changing their business strategies in the current hyperinflationary and increasingly competitive media market, updating how they create user-centered practices in search of ultimate commercial success. It also illustrates how different commercial streaming service formats end up with similar solutions to the challenges. The study is a comparative analysis of the streaming phenomenon as it happens in real-time, complementing the observation and evaluation of the latest updates in the streaming industry and predicting the future trends of global brands in the digital ecosystem under different commercial and cultural logics