7 research outputs found
Corrigendum to “IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer”
Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease
Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson's disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum (STR) regions. However, the underlying molecular mechanism linking parkin with the etiology of PD remains elusive. Here we report that p62, a critical regulator for protein quality control, inclusion body formation, selective autophagy and diverse signaling pathways, is a new substrate of parkin. P62 levels were increased in the SN and STR regions, but not in other brain regions in parkin knockout mice. Parkin directly interacts with and ubiquitinates p62 at the K13 to promote proteasomal degradation of p62 even in the absence of ATG5. Pathogenic mutations, knockdown of parkin or mutation of p62 at K13 prevented the degradation of p62. We further showed that parkin deficiency mice have pronounced loss of tyrosine hydroxylase positive neurons and have worse performance in motor test when treated with 6-hydroxydopamine hydrochloride in aged mice. These results suggest that, in addition to their critical role in regulating autophagy, p62 are subjected to parkin mediated proteasomal degradation and implicate that the dysregulation of parkin/p62 axis may involve in the selective vulnerability of neuronal cells during the onset of PD pathogenesis
Adaptive leader-following formation control with collision avoidance for a class of second-order nonlinear multi-agent systems
Two-Dimensional CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> Perovskite Nanosheets for Ultrafast Pulsed Fiber Lasers
Even though the nonlinear
optical effects of solution processed organic–inorganic perovskite
films have been studied, the nonlinear optical properties in two-dimensional
(2D) perovskites, especially their applications for ultrafast photonics,
are largely unexplored. In comparison to bulk perovskite films, 2D
perovskite nanosheets with small thicknesses of a few unit cells are
more suitable for investigating the intrinsic nonlinear optical properties
because bulk recombination of photocarriers and the nonlinear scattering
are relatively small. In this research, we systematically investigated
the nonlinear optical properties of 2D perovskite nanosheets derived
from a combined solution process and vapor phase conversion method.
It was found that 2D perovskite nanosheets have stronger saturable
absorption properties with large modulation depth and very low saturation
intensity compared with those of bulk perovskite films. Using an all
dry transfer method, we constructed a new type of saturable absorber
device based on single piece 2D perovskite nanosheet. Stable soliton
state mode-locking was achieved, and ultrafast picosecond pulses were
generated at 1064 nm. This work is likely to pave the way for ultrafast
photonic and optoelectronic applications based on 2D perovskites