228 research outputs found
Can Virtual Reality Elicit More Empathy: A Meta-analysis Based on 19 Randomized Controlled Trials
Empathy is an individual’s objective and insightful awareness of the feelings and behavior of others. There are mainly two types of empathy: cognitive and affective. Empathy plays a crucial role in improving student academic performance as well as in promoting social interaction of the individual. Virtual reality is generally defined as a medium technology which can provide simulative experiences in a computer-created environment and has the capacity to enhance human empathy by offering immersive learning experiences. This study conducted a meta-analysis to evaluate the effects of virtual reality-assisted instruction on eliciting empathy in students and to discern the influences of various variables on student empathetic behavior. The following two questions were proposed: Is virtual reality-assisted instruction more effective in enhancing student empathy than traditional teaching methods? How are research design, subject matter and process features related to the promotive effects of virtual reality on student empathetic competence
Effects of Online Learning on Student Moral Development: A Meta-analysis Based on 42 Experimental and Quasi-experimental Studies
The widespread practices of online learning have sparked increasing interest in its educational efficacy. The effects of online learning on learners’ moral development remain contentious in existing research. The purpose of this meta-analysis was to ascertain how online leaning impact students’ moral development. It included 42 experimental and quasi-experimental studies with an aggregate sample of 5303 learners after the processes of literature screening, data extraction, and risk of bias assessment. Analytical results revealed that online learning had positive effects on student moral understanding and reasoning, but no significant impact on student moral emotions and behavior. Subgroup analyses by student type, course type, online learning pattern, and involvement of interactive activity showed that there were disparities in the effect size between all subgroups and that only the moderating effect of student type on student moral reasoning was statistically significant
Tiazofurin inhibits oral cancer growth in vitro and in vivo via upregulation of miR-204 expression
Purpose: To investigate the effect of tiazofurin on proliferation and growth of oral cancer cells, and the associated mechanism(s) of action.Methods: The effect of tiazofurin on the cytotoxicity of SCC-VII and SCC-25 oral cancer cells were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while cell apoptosis was determined by flow cytometry. Western blotting was used for assaying proteinexpressions.Results: Tiazofurin inhibited the viability of the oral cancer cells in a concentration-based manner (p < 0.05). Tiazofurin treatment at a dose of 2.0 μM reduced the proliferation of SCC-VII and SCC-25 cells to 25 and 22 %, respectively. Apoptosis was significantly increased in SCC-VII and SCC-25 cells by tiazofurin treatment, relative to untreated cells (p < 0 .05). Tiazofurin also increased the activation levels of caspase-3 and caspase-9 and downregulated the expressions of p-Akt and p-mTOR in the two cancer cell lines. Moreover, miR-204 expression was significantly promoted in the tiazofurin-treated cells, when compared to control (p < 0 .05). In SCC-VII cells, treatment with tiazofurin suppressed Factin expression, relative to control.Conclusion: These results demonstrate that tiazofurin inhibits the viability and proliferation of SCC-VII and SCC-25 cancer cells via induction of apoptosis and activation of caspase-3/caspase-9. Moreover, tiazofurin targets Akt/mTOR pathway, and upregulats the expressions of F-actin and miR-204 in the oral carcinoma cells. These findings suggest that tiazofurin has a potential for use as an effective treatment for oral cancer.
Keywords: Oral cancer, Tiazofurin, Apoptosis, Caspase, Cytotoxicit
Achieving Scalable Capacity in Wireless Mesh Networks
Wireless mesh networks play a critical role in enabling key networking
scenarios in beyond-5G (B5G) and 6G networks, including integrated access and
backhaul (IAB), multi-hop sidelinks, and V2X. However, it still poses a
challenge to deliver scalable per-node throughput via mesh networking, which
significantly limits the potential of large-scale deployment of wireless mesh
networks. Existing research has achieved per-node throughput in a dense
network, but how to achieve scalability remains an unresolved issue for an
extended wireless network where the network size increases with a constant node
density. This issue prevents a wireless mesh network from large-scale
deployment. To this end, this paper aims to develop a theoretical approach to
achieving scalable per-node throughput in wireless mesh networks. First, the
key factors that limit the per-node throughput of wireless mesh networks are
analyzed, through which two major ones are identified, i.e., link sharing and
interference. Next, a multi-tier hierarchical architecture is proposed to
overcome the link-sharing issue. The inter-tier interference under this
architecture is then mitigated by utilizing orthogonal frequency allocation
between adjacent tiers, while the intra-tier interference is reduced by
considering two specific transmission schemes, one is MIMO spatial multiplexing
with time-division, the other is MIMO beamforming. Theoretical analysis shows
that the multi-tier mesh networking architecture can achieve a per-node
throughput of in both schemes, as long as certain conditions on
network parameters including bandwidth, antenna numbers, and node numbers of
each tier are satisfied. A case study on a realistic deployment of 10,000 nodes
is then carried out, which demonstrates that a scalable throughput of
is achievable with a reasonable assumption on bandwidth and antenna
numbers.Comment: ~12pages, 4 figures, submitted to IEEE TIT, part of this work has
been published in IEEE MASS 202
Model and Evaluation: Towards Fairness in Multilingual Text Classification
Recently, more and more research has focused on addressing bias in text
classification models. However, existing research mainly focuses on the
fairness of monolingual text classification models, and research on fairness
for multilingual text classification is still very limited. In this paper, we
focus on the task of multilingual text classification and propose a debiasing
framework for multilingual text classification based on contrastive learning.
Our proposed method does not rely on any external language resources and can be
extended to any other languages. The model contains four modules: multilingual
text representation module, language fusion module, text debiasing module, and
text classification module. The multilingual text representation module uses a
multilingual pre-trained language model to represent the text, the language
fusion module makes the semantic spaces of different languages tend to be
consistent through contrastive learning, and the text debiasing module uses
contrastive learning to make the model unable to identify sensitive attributes'
information. The text classification module completes the basic tasks of
multilingual text classification. In addition, the existing research on the
fairness of multilingual text classification is relatively simple in the
evaluation mode. The evaluation method of fairness is the same as the
monolingual equality difference evaluation method, that is, the evaluation is
performed on a single language. We propose a multi-dimensional fairness
evaluation framework for multilingual text classification, which evaluates the
model's monolingual equality difference, multilingual equality difference,
multilingual equality performance difference, and destructiveness of the
fairness strategy. We hope that our work can provide a more general debiasing
method and a more comprehensive evaluation framework for multilingual text
fairness tasks
Facile Solution Process of VO2 Film with Mesh Morphology for Enhanced Thermochromic Performance
The fabrication and applications of VO2 film continue to be of considerable interest due to their good thermochromic performance for smart windows. However, low visible transmittance (Tlum) and solar modulation efficiency (∆Tsol) impede the application of VO2 film, and they are difficult to improve simultaneously. Here, a facile zinc solution process was employed to control the surface structure of dense VO2 film and the processed VO2 film showed enhanced visible transmittance and solar modulation efficiency, which were increased by 7.5% and 9.5%, respectively, compared with unprocessed VO2 film. This process facilitated the growth of layered basic zinc acetate (LBZA) nanosheets to form mesh morphology on the surface of VO2 film, where LBZA nanosheets enhance the visible transmittance as an anti-reflection film. The mesh morphology also strengthened the solar modulation efficiency with small caves between nanosheets by multiplying the times of reflection. By increasing the zinc concentration from 0.05 mol/L to 0.20 mol/L, there were more LBZA nanosheets on the surface of the VO2 film, leading to an increase in the solar/near-infrared modulation efficiency. Therefore, this work revealed the relationship between the solution process, surface structure, and optical properties, and thus can provide a new method to prepare VO2 composite film with desirable performance for applications in smart windows
Functional conservation and divergence of Miscanthus lutarioriparius GT43 gene family in xylan biosynthesis
Background: Xylan is the most abundant un-cellulosic polysaccharides of plant cell walls. Much progress in xylan biosynthesis has been gained in the model plant species Arabidopsis. Two homologous pairs Irregular Xylem 9 (IRX9)/9L and IRX14/14L from glycosyltransferase (GT) family 43 have been proved to play crucial roles in xylan backbone biosynthesis. However, xylan biosynthesis in grass such as Miscanthus remains poorly understood
Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway
BACKGROUND: The adapter proteins Appl1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine domain, and leucine zipper motif 1) and Appl2 are highly homologous and involved in several signaling pathways. While previous studies have shown that Appl1 plays a pivotal role in adiponectin signaling and insulin secretion, the physiological functions of Appl2 are largely unknown. RESULTS: In the present study, the role of Appl2 in sepsis shock was investigated by using Appl2 knockout (KO) mice. When challenged with lipopolysaccharides (LPS), Appl2 KO mice exhibited more severe symptoms of endotoxin shock, accompanied by increased production of proinflammatory cytokines. In comparison with the wild-type control, deletion of Appl2 led to higher levels of TNF-α and IL-1β in primary macrophages. In addition, phosphorylation of Akt and its downstream effector NF-κB was significantly enhanced. By co-immunoprecipitation, we found that Appl2 and Appl1 interacted with each other and formed a complex with PI3K regulatory subunit p85α, which is an upstream regulator of Akt. Consistent with these results, deletion of Appl1 in macrophages exhibited characteristics of reduced Akt activation and decreased the production of TNFα and IL-1β when challenged by LPS. CONCLUSIONS: Results of the present study demonstrated that Appl2 is a critical negative regulator of innate immune response via inhibition of PI3K/Akt/NF-κB signaling pathway by forming a complex with Appl1 and PI3K.published_or_final_versio
Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health. We recently reported a replication-defective human cytomegalovirus with restored pentameric complex glycoprotein H (gH)/gL/pUL128-131 for prevention of congenital HCMV infection. While the quantity of vaccine-induced antibody responses can be measured in a viral neutralization assay, assessing the quality of such responses, including the ability of vaccine-induced antibodies to cross-neutralize the field strains of HCMV, remains a challenge. In this study, with a panel of neutralizing antibodies from three healthy human donors with natural HCMV infection or a vaccinated animal, we mapped eight sites on the dominant virus-neutralizing antigen-the pentameric complex of glycoprotein H (gH), gL, and pUL128, pUL130, and pUL131. By evaluating the site-specific antibodies in vaccine immune sera, we demonstrated that vaccination elicited functional antiviral antibodies to multiple neutralizing sites in rhesus macaques, with quality attributes comparable to those of CMV hyperimmune globulin. Furthermore, these immune sera showed antiviral activities against a panel of genetically distinct HCMV clinical isolates. These results highlighted the importance of understanding the quality of vaccine-induced antibody responses, which includes not only the neutralizing potency in key cell types but also the ability to protect against the genetically diverse field strains. IMPORTANCE HCMV is the leading cause of congenital viral infection, and development of a preventive vaccine is a high public health priority. To understand the strain coverage of vaccine-induced immune responses in comparison with natural immunity, we used a panel of broadly neutralizing antibodies to identify the immunogenic sites of a dominant viral antigen-the pentameric complex. We further demonstrated that following vaccination of a replication-defective virus with the restored pentameric complex, rhesus macaques can develop broadly neutralizing antibodies targeting multiple immunogenic sites of the pentameric complex. Such analyses of site-specific antibody responses are imperative to our assessment of the quality of vaccine-induced immunity in clinical studies
Cotton WATs Modulate SA Biosynthesis and Local Lignin Deposition Participating in Plant Resistance Against Verticillium dahliae
Verticillium wilt, caused by Verticillium dahliae, seriously limits cotton production. It is difficult to control this pathogen damage mainly due to the complexity of the molecular mechanism of plant resistance to V. dahliae. Here, we identified three homologous cotton Walls Are Thin (WAT) genes, which were designated as GhWAT1, GhWAT2, and GhWAT3. The GhWATs were predominantly expressed in the roots, internodes, and hypocotyls and induced by infection with V. dahliae and treatment with indole-3-acetic acid (IAA) and salicylic acid (SA). GhWAT1-, GhWAT2-, or GhWAT3-silenced plants showed a comparable phenotype and level of resistance with control plants, but simultaneously silenced three GhWATs (GhWAT123-silenced), inhibited plant growth and increased plant resistance to V. dahliae, indicating that these genes were functionally redundant. In the GhWAT123-silenced plants, the expression of SA related genes was significantly upregulated compared with the control, resulting in an increase of SA level. Moreover, the histochemical analysis showed that xylem development was inhibited in GhWAT123-silenced plants compared with the control. However, lignin deposition increased in the xylem of the GhWAT123-silenced plants compared to the control, and there were higher expression levels of lignin synthesis- and lignifications-related genes in the GhWAT123-silenced plants. Collectively, the results showed that GhWATs in triple-silenced plants acts as negative regulators of plant resistance against V. dahliae. The potential mechanism of the WATs functioning in the plant defence can modulate the SA biosynthesis and lignin deposition in the xylem
- …