5,339 research outputs found
The cDNA and deduced amino acid sequence of the Îł subunit of the L-type calcium channel from rabbit skeletal muscle
Complementary DNAs for the Îł subunit of the calcium channel of rabbit skeletal muscle were isolated on the basis of peptide sequences derived from the purified protein. The deduced primary structure is without homology to other known protein sequences and is consistent with the Îł subunit being an integral membrane protein
Evidence for line nodes in the energy gap of the overdoped Ba(FeCo)As from low-temperature specific heat measurements
Low-temperature specific heat (SH) is measured on
Ba(FeCo)As single crystals in a wide doping region under
different magnetic fields. For the overdoped sample, we find the clear evidence
for the presence of term in the data, which is absent both for the
underdoped and optimal doped samples, suggesting the presence of line nodes in
the energy gap of the overdoped samples. Moreover, the field induced electron
specific heat coefficient increases more quickly with the
field for the overdoped sample than the underdoped and optimal doped ones,
giving another support to our arguments. Our results suggest that the
superconducting gap(s) in the present system may have different structures
strongly depending on the doping regions.Comment: 5 pages, 4 figure
Curie-like paramagnetism due to incomplete Zhang-Rice singlet formation in La2-xSrxCuO4
In an effort to elucidate the origin of the Curie-like paramagnetism that is
generic for heavily-overdoped cuprates, we have performed high transverse-field
muon spin rotation (TF-muSR) measurements of La2-xSrxCuO4 single crystals over
the Sr content range 0.145 < x < 0.33. We show that the x-dependence of the
previously observed field-induced broadening of the internal magnetic field
distribution above the superconducting transition temperature Tc reflects the
presence of two distinct contributions. One of these becomes less pronounced
with increasing x and is attributed to diminishing antiferromagnetic
correlations. The other grows with increasing x, but decreases above x ~ 0.30,
and is associated with the Curie-like term in the bulk magnetic susceptibility.
In contrast to the Curie-like term, however, this second contribution to the
TF-muSR line width extends back into the underdoped regime. Our findings imply
a coexistence of antiferromagnetically correlated and paramagnetic moments,
with the latter becoming dominant beyond x ~ 0.185. This suggests that the
doped holes do not neutralize all Cu spins via the formation of Zhang-Rice
singlets. Moreover, the paramagnetic component of the TF-muSR line width is
explained by holes progressively entering the Cu 3d_{x^2-y^2} orbital with
doping.Comment: 8 pages, 7 figure
Exponentially growing solutions in homogeneous Rayleigh-Benard convection
It is shown that homogeneous Rayleigh-Benard flow, i.e., Rayleigh-Benard
turbulence with periodic boundary conditions in all directions and a volume
forcing of the temperature field by a mean gradient, has a family of exact,
exponentially growing, separable solutions of the full non-linear system of
equations. These solutions are clearly manifest in numerical simulations above
a computable critical value of the Rayleigh number. In our numerical
simulations they are subject to secondary numerical noise and resolution
dependent instabilities that limit their growth to produce statistically steady
turbulent transport.Comment: 4 pages, 3 figures, to be published in Phys. Rev. E - rapid
communication
Bereaved Parentsâ Health Status During the First 6 Months After Their Childâs Death
Purpose:
To examine bereaved parentsâ physical, mental, and social health during the first 6 months after their childâs (<12 years) death from a life-threatening illness.
Background and Significance:
Bereaved parents have higher mortality and morbidity rates when compared to nonbereaved parents. Acute illnesses, hospitalizations, and medication changes are highest in the first 6 months. An understanding of bereaved parentsâ health risk indicators can help inform development of health promotion and disease prevention measures.
Methods and Analysis:
A prospective descriptive study examined 8 parent dyads. Parents completed health surveys (Patient-Reported Outcomes Measurement Information Systemâglobal, social, and sleep; Brief Symptom Inventory [BSI] 18), which are used to assess parentsâ health at 3 and 6 months after their childâs death. Demographic data included a medical history, hospital or emergency department visits, and smoking and alcohol intake. Descriptive statistics were used to compare parentsâ scores to US general population scores.
Findings:
Mothersâ and fathersâ physical, mental, and sleep health scores were typically within 1 to 2 standard deviations of the population norms. However, their social health scores were as low as 3 standard deviations and all parentsâ scores were below population norms. Four (25%) of the 16 parents had new diagnosis during the first 6 months. Based on the BSI-18, 3 parents had their scores above population cutoffs, which warranted a need for further clinical evaluation.
Conclusions:
Health data highlight the âat-riskâ health status of bereaved parents. Further validation of these data is required to support the development of health promotion and disease prevention programs
Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer.
The poor prognosis for patients with inflammatory breast cancer (IBC) compared to patients with other types of breast cancers emphasizes the need to better understand the molecular underpinnings of this disease with the goal of developing effective targeted therapeutics. Dysregulation of matriptase expression, an epithelial-specific member of the type II transmembrane serine protease family, has been demonstrated in many different cancer types. To date, no studies have assessed the expression and potential pro-oncogenic role of matriptase in IBC. We examined the functional relationship between matriptase and the HGF/c-MET signaling pathway in the IBC cell lines SUM149 and SUM190, and in IBC patient samples. Matriptase and c-Met proteins are localized on the surface membrane of IBC cells and their expression is strongly correlated in infiltrating cancer cells and in the cancer cells of lymphatic emboli in patient samples. Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro-HGF to active HGF and subsequent c-Met-mediated signaling, leading to efficient impairment of proliferation and invasion of IBC cells. These data show the potential of matriptase inhibitors as a novel targeted therapy for IBC, and lay the groundwork for the development and testing of such drugs
Quantum number projection at finite temperature via thermofield dynamics
Applying the thermo field dynamics, we reformulate exact quantum number
projection in the finite-temperature Hartree-Fock-Bogoliubov theory. Explicit
formulae are derived for the simultaneous projection of particle number and
angular momentum, in parallel to the zero-temperature case. We also propose a
practical method for the variation-after-projection calculation, by
approximating entropy without conflict with the Peierls inequality. The quantum
number projection in the finite-temperature mean-field theory will be useful to
study effects of quantum fluctuations associated with the conservation laws on
thermal properties of nuclei.Comment: 27 pages, using revtex4, to be published in PR
Existence of Dynamical Scaling in the Temporal Signal of Time Projection Chamber
The temporal signals from a large gas detector may show dynamical scaling due
to many correlated space points created by the charged particles while passing
through the tracking medium. This has been demonstrated through simulation
using realistic parameters of a Time Projection Chamber (TPC) being fabricated
to be used in ALICE collider experiment at CERN. An interesting aspect of this
dynamical behavior is the existence of an universal scaling which does not
depend on the multiplicity of the collision. This aspect can be utilised
further to study physics at the device level and also for the online monitoring
of certain physical observables including electronics noise which are a few
crucial parameters for the optimal TPC performance.Comment: 5 pages, 6 figure
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