Achieving Effective Innovation Based On TRIZ Technological Evolution

Organised by: Cranfield UniversityThis paper outlines the conception of effective innovation and discusses the method to achieve it. Effective Innovation is constrained on the path of technological evolution so that the corresponding path must be detected before conceptual design of the product. The process of products technological evolution is a technical developing process that the products approach to Ideal Final Result (IFR). During the process, the sustaining innovation and disruptive innovation carry on alternately. By researching and forecasting potential techniques using TRIZ technological evolution theory, the effective innovation can be achieved finally.Mori Seiki – The Machine Tool Compan

Work Function of Single-wall Silicon Carbide Nanotube

Using first-principles calculations, we study the work function of single wall silicon carbide nanotube (SiCNT). The work function is found to be highly dependent on the tube chirality and diameter. It increases with decreasing the tube diameter. The work function of zigzag SiCNT is always larger than that of armchair SiCNT. We reveal that the difference between the work function of zigzag and armchair SiCNT comes from their different intrinsic electronic structures, for which the singly degenerate energy band above the Fermi level of zigzag SiCNT is specifically responsible. Our finding offers potential usages of SiCNT in field-emission devices.Comment: 3 pages, 3 figure

Decorrelation of Neutral Vector Variables: Theory and Applications

In this paper, we propose novel strategies for neutral vector variable decorrelation. Two fundamental invertible transformations, namely, serial nonlinear transformation and parallel nonlinear transformation, are proposed to carry out the decorrelation. For a neutral vector variable, which is not multivariate-Gaussian distributed, the conventional principal component analysis cannot yield mutually independent scalar variables. With the two proposed transformations, a highly negatively correlated neutral vector can be transformed to a set of mutually independent scalar variables with the same degrees of freedom. We also evaluate the decorrelation performances for the vectors generated from a single Dirichlet distribution and a mixture of Dirichlet distributions. The mutual independence is verified with the distance correlation measurement. The advantages of the proposed decorrelation strategies are intensively studied and demonstrated with synthesized data and practical application evaluations

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells.

BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation of viral protein in the ER by viral infection. Then, unfolded protein response (UPR) is activated to alleviate the stress. Zika virus (ZIKV) is a mosquito-borne flavivirus and its infection causes microcephaly in newborns and serious neurological complications in adults. Here, we investigated ER stress and the regulating model of UPR in ZIKV-infected neural cells in vitro and in vivo. METHODS: Mice deficient in type I and II IFN receptors were infected with ZIKV via intraperitoneal injection and the nervous tissues of the mice were assayed at 5 days post-infection. The expression of phospho-IRE1, XBP1, and ATF6 which were the key markers of ER stress were analyzed by immunohistochemistry assay in vivo. Additionally, the nuclear localization of XBP1s and ATF6n were analyzed by immunohistofluorescence. Furthermore, two representative neural cells, neuroblastoma cell line (SK-N-SH) and astrocytoma cell line (CCF-STTG1), were selected to verify the ER stress in vitro. The expression of BIP, phospho-elF2α, phospho-IRE1, and ATF6 were analyzed through western blot and the nuclear localization of XBP1s was performed by confocal immunofluorescence microscopy. RT-qPCR was also used to quantify the mRNA level of the UPR downstream genes in vitro and in vivo. RESULTS: ZIKV infection significantly upregulated the expression of ER stress markers in vitro and in vivo. Phospho-IRE1 and XBP1 expression significantly increased in the cerebellum and mesocephalon, while ATF6 expression significantly increased in the mesocephalon. ATF6n and XBP1s were translocated into the cell nucleus. The levels of BIP, ATF6, phospho-elf2α, and spliced xbp1 also significantly increased in vitro. Furthermore, the downstream genes of UPR were detected to investigate the regulating model of the UPR during ZIKV infection in vitro and in vivo. The transcriptional levels of atf4, gadd34, chop, and edem-1 in vivo and that of gadd34 and chop in vitro significantly increased. CONCLUSION: Findings in this study demonstrated that ZIKV infection activates ER stress in neural cells. The results offer clues to further study the mechanism of neuropathogenesis caused by ZIKV infection

Enabling Thin and Flexible Solid-State Composite Electrolytes by the Scalable Solution Process

All solid-state batteries (ASSBs) have the potential to deliver higher energy densities, wider operating temperature range, and improved safety compared with today's liquid-electrolyte-based batteries. However, of the various solid-state electrolyte (SSE) classes - polymers, sulfides, or oxides - none alone can deliver the combined properties of ionic conductivity, mechanical, and chemical stability needed to address scalability and commercialization challenges. While promising strategies to overcome these include the use of polymer/oxide or sulfide composites, there is still a lack of fundamental understanding between different SSE-polymer-solvent systems and its selection criteria. Here, we isolate various SSE-polymer-solvent systems and study their molecular level interactions by combining various characterization tools. With these findings, we introduce a suitable Li7P3S11SSE-SEBS polymer-xylene solvent combination that significantly reduces SSE thickness (∼50 μm). The SSE-polymer composite displays high room temperature conductivity (0.7 mS cm-1) and good stability with lithium metal by plating and stripping over 2000 h at 1.1 mAh cm-2. This study suggests the importance of understanding fundamental SSE-polymer-solvent interactions and provides a design strategy for scalable production of ASSBs

Recovery of DNA from agarose gel by trap method

Recovery of DNA from agarose gel electrophoresis is a basic operation during molecular cloning. Circular or linear DNA fragments which vary from 1.5 to 6.5 kb and correspond to 1 kb marker can be recovered from 0.8 to 1.0% agarose gel smoothly with a simple and rapid trap method. The recovery efficiency could be more than 70% and the quality of the recovered DNA is proved to be good enough for future research. Here, we provided another good method to recover DNA from agarose gel besides using commercial kits.Key words: Trap method, recovery of DNA, agarose gel electrophoresis

Mesh reinforced membrane and its wrinkling characteristics

Membrane structures have received a wide range of attention in applications of large-scale spacecrafts, such as inflated wing, light-than-air (LTA) airship and membrane antenna reflector, and so on. These spacecrafts need to be designed as high loading-efficiency components or structures, especially with high shape precision [1]. Therefore, some special processing and design should be done on the membranes so as to satisfy with special requirements, such as free wrinkle, ultralightweight, high shape precision, and high load-carrying ability, etc.. Several applications may give us good ideas to deal with abovementioned problems in membrane structures. One example is easy to be remembered, that is, the Super-Pressure Balloons (SPB) [2-4] covered by some ropes on membrane surface to make the balloon stable and strong. The similar considerations are also applied to some gossamer spacecraft components or structures, taking the Lunar habitat [5] as an example

Messaging media perceptions and preferences: a pilot study in two distinct cultures

This study empirically examines university students' perceptions and their views of when they adopt Instant Messaging (IM) and Short Messaging Service (SMS) and how they perceive and prefer these two media, in conjunction with other media (face-to-face, telephone, and email), in their university learning activities across two different cultural contexts: Australian university and Chinese university. The overall results of this study support some aspects of media richness theory. Although IM is perceived to be richer than email, it is not perceived to be the most popular medium for any situation. Data also demonstrate cultural differences in media perceptions of and preferences for new media. Specifically, Australian students have higher preference for email than their Chinese counterparts and Australian students also perceive SMS as leaner in terms of medium richness and have less preference for SMS than their Chinese counterparts. © 2007 IEEE