KALM: Knowledge-Aware Integration of Local, Document, and Global Contexts for Long Document Understanding

With the advent of pre-trained language models (LMs), increasing research efforts have been focusing on infusing commonsense and domain-specific knowledge to prepare LMs for downstream tasks. These works attempt to leverage knowledge graphs, the de facto standard of symbolic knowledge representation, along with pre-trained LMs. While existing approaches leverage external knowledge, it remains an open question how to jointly incorporate knowledge graphs representing varying contexts, from local (e.g., sentence), to document-level, to global knowledge, to enable knowledge-rich and interpretable exchange across these contexts. Such rich contextualization can be especially beneficial for long document understanding tasks since standard pre-trained LMs are typically bounded by the input sequence length. In light of these challenges, we propose KALM, a Knowledge-Aware Language Model that jointly leverages knowledge in local, document-level, and global contexts for long document understanding. KALM first encodes long documents and knowledge graphs into the three knowledge-aware context representations. It then processes each context with context-specific layers, followed by a context fusion layer that facilitates interpretable knowledge exchange to derive an overarching document representation. Extensive experiments demonstrate that KALM achieves state-of-the-art performance on three long document understanding tasks across 6 datasets/settings. Further analyses reveal that the three knowledge-aware contexts are complementary and they all contribute to model performance, while the importance and information exchange patterns of different contexts vary with respect to different tasks and datasets

STARA fight or flight: a two-wave time-lagged study of challenge and hindrance appraisal of STARA awareness on basic psychological needs and individual competitiveness productivity among hospitality employees

The introduction of smart technologies, artificial intelligence, robotics, and algorithms (STARA) has changed the workforce significantly, with many concerns about its impact on employees. This study elucidates how one’s appraisal of this situation would influence basic psychological needs and individual competitiveness productivity. Using a two-wave time-lagged study, data collected from 224 hospitality employees was examined using the partial least squares method structural equation modelling (PLS-SEM). Results suggested that individual appraisal towards STARA awareness has differential outcomes towards satisfying basic psychological needs. Among the three basic psychological needs, the needs for relatedness and competency were positively related to individual competitive productivity (ICP). We extend extant studies by incorporating challenge-hindrance framework and self-determination theory (SDT) in the context of the future of work involving STARA. It advances the body of knowledge in understanding a more fundamental issue of how STARA can bring out the best in employees, how STARA shapes employees’ opinions and perspectives of the work they are doing, and what they should do to work alongside STARA

Deciphering the molecular landscape: integrating single-cell transcriptomics to unravel myofibroblast dynamics and therapeutic targets in clear cell renal cell carcinomas

BackgroundClear cell renal cell carcinomas (ccRCCs) epitomize the most formidable clinical subtype among renal neoplasms. While the impact of tumor-associated fibroblasts on ccRCC progression is duly acknowledged, a paucity of literature exists elucidating the intricate mechanisms and signaling pathways operative at the individual cellular level.MethodsEmploying single-cell transcriptomic analysis, we meticulously curated UMAP profiles spanning substantial ccRCC populations, delving into the composition and intrinsic signaling pathways of these cohorts. Additionally, Myofibroblasts were fastidiously categorized into discrete subpopulations, with a thorough elucidation of the temporal trajectory relationships between these subpopulations. We further probed the cellular interaction pathways connecting pivotal subpopulations with tumors. Our endeavor also encompassed the identification of prognostic genes associated with these subpopulations through Bulk RNA-seq, subsequently validated through empirical experimentation.ResultsA notable escalation in the nFeature and nCount of Myofibroblasts and EPCs within ccRCCs was observed, notably enriched in oxidation-related pathways. This phenomenon is postulated to be closely associated with the heightened metabolic activities of Myofibroblasts and EPCs. The Myofibroblasts subpopulation, denoted as C3 HMGA1+ Myofibroblasts, emerges as a pivotal subset, displaying low differentiation and positioning itself at the terminal point of the temporal trajectory. Intriguingly, these cells exhibit a high degree of interaction with tumor cells through the MPZ signaling pathway network, suggesting that Myofibroblasts may facilitate tumor progression via this pathway. Prognostic genes associated with C3 were identified, among which TUBB3 is implicated in potential resistance to tumor recurrence. Finally, experimental validation revealed that the knockout of the key gene within the MPZ pathway, MPZL1, can inhibit tumor activity, proliferation, invasion, and migration capabilities.ConclusionThis investigation delves into the intricate mechanisms and interaction pathways between Myofibroblasts and ccRCCs at the single-cell level. We propose that targeting MPZL1 and the oxidative phosphorylation pathway could serve as potential key targets for treating the progression and recurrence of ccRCC. This discovery paves the way for new directions in the treatment and prognosis diagnosis of ccRCC in the future

Detecting Spoilers in Movie Reviews with External Movie Knowledge and User Networks

Online movie review platforms are providing crowdsourced feedback for the film industry and the general public, while spoiler reviews greatly compromise user experience. Although preliminary research efforts were made to automatically identify spoilers, they merely focus on the review content itself, while robust spoiler detection requires putting the review into the context of facts and knowledge regarding movies, user behavior on film review platforms, and more. In light of these challenges, we first curate a large-scale network-based spoiler detection dataset LCS and a comprehensive and up-to-date movie knowledge base UKM. We then propose MVSD, a novel Multi-View Spoiler Detection framework that takes into account the external knowledge about movies and user activities on movie review platforms. Specifically, MVSD constructs three interconnecting heterogeneous information networks to model diverse data sources and their multi-view attributes, while we design and employ a novel heterogeneous graph neural network architecture for spoiler detection as node-level classification. Extensive experiments demonstrate that MVSD advances the state-of-the-art on two spoiler detection datasets, while the introduction of external knowledge and user interactions help ground robust spoiler detection. Our data and code are available at https://github.com/Arthur-Heng/Spoiler-DetectionComment: EMNLP 202

Effect of NPK, organic manure and their combination on growth, yield and nutrient uptake of chilli (Capsicum Annum L.)

A field experiment was conducted at the research area of department of horticulture, Institute of tropical agriculture and forestry, Hainan University, Haikou, Hainan, China, during the winter season 2016-2017. The research was arranged in randomized complete block design with nine treatments of organic manures in combination with NPK fertilizers having three replications. The highest yield was recorded with T9 treatment (N: P: K 100:50:50+FYM@8 ton per hectare). Plant height at harvesting, number of branches plant-1, number of fruits plant-1, fruit width, fruit length and fruit weight increased significantly with T9 treatment (N: P: K 100:50:50+FYM@8 ton per hectare). Similarly application of NPK100%+FYM@8 ton per hectare increased oleoresin yield and ascorbic acid content. Application of FYM@8 ton per hectare in combination with NPK100% increased the uptake of nutrients (N, P, K, Ca, S, and Fe) as compared to control. Similar results were also found in other organic manures along with inorganic fertilizer. The highest net return (Rs. 30183 per hectare) was achieved with the application of NPK100%+FYM@8 ton per hectare followed by NPK100%+ PM@6 ton per hectare, NPK100%+VC@10 ton per hectare and NPK100%+C@7 ton per hectar

Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl 4

Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30–100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. Human umbilical cord MSC-derived exosomes (hucMSC-Ex) play important roles in liver repair. However, the effects and mechanisms of hucMSC-Ex on liver injury development remain elusive. Mouse models of acute and chronic liver injury and liver tumor were induced by carbon tetrachloride (CCl4) injection, followed by administration of hucMSC-Ex via the tail vein. Alleviation of liver injury by hucMSC-Ex was determined. We further explored the production of oxidative stress and apoptosis in the development of liver injury and compared the antioxidant effects of hucMSC-Ex with frequently used hepatic protectant, bifendate (DDB) in liver injury. hucMSC-Ex alleviated CCl4-induced acute liver injury and liver fibrosis and restrained the growth of liver tumors. Decreased oxidative stress and apoptosis were found in hucMSC-Ex-treated mouse models and liver cells. Compared to bifendate (DDB) treatment, hucMSC-Ex presented more distinct antioxidant and hepatoprotective effects. hucMSC-Ex may suppress CCl4-induced liver injury development via antioxidant potentials and could be a more effective antioxidant than DDB in CCl4-induced liver tumor development

Association of FTH1-expressing circulating tumor cells with efficacy of neoadjuvant chemotherapy for patients with breast cancer: a prospective cohort study

Background The association between different phenotypes and genotypes of circulating tumor cells (CTCs) and efficacy of neoadjuvant chemotherapy (NAC) remains uncertain. This study was conducted to evaluate the relationship of FTH1 gene-associated CTCs (F-CTC) with/without epithelial-mesenchymal transition (EMT) markers, or their dynamic changes with the efficacy of NAC in patients with non-metastatic breast cancer. Patients and Methods This study enrolled 120 patients with non-metastatic breast cancer who planned to undergo NAC. The FTH1 gene and EMT markers in CTCs were detected before NAC (T0), after 2 cycles of chemotherapy (T1), and before surgery (T2). The associations of these different types of CTCs with rates of pathological complete response (pCR) and breast-conserving surgery (BCS) were evaluated using the binary logistic regression analysis. Results F-CTC in peripheral blood ≥1 at T0 was an independent factor for pCR rate in patients with HER2-positive (odds ratio [OR]=0.08, 95% confidence interval [CI], 0.01-0.98, P = .048). The reduction in the number of F-CTC at T2 was an independent factor for BCS rate (OR = 4.54, 95% CI, 1.14-18.08, P = .03). Conclusions The number of F-CTC prior to NAC was related to poor response to NAC. Monitoring of F-CTC may help clinicians formulate personalized NAC regimens and implement BCS for patients with non-metastatic breast cancer

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages