Photon orbital angular momentum and torque metrics for single telescopes and interferometers

Context. Photon orbital angular momentum (POAM) is normally invoked in a quantum mechanical context. It can, however, also be adapted to the classical regime, which includes observational astronomy. Aims. I explain why POAM quantities are excellent metrics for describing the end-to-end behavior of astronomical systems. To demonstrate their utility, I calculate POAM probabilities and torques from holography measurements of EVLA antenna surfaces. Methods. With previously defined concepts and calculi, I present generic expressions for POAM spectra, total POAM, torque spectra, and total torque in the image plane. I extend these functional forms to describe the specific POAM behavior of single telescopes and interferometers. Results. POAM probabilities of spatially uncorrelated astronomical sources are symmetric in quantum number. Such objects have zero intrinsic total POAM on the celestial sphere, which means that the total POAM in the image plane is identical to the total torque induced by aberrations within propagation media & instrumentation. The total torque can be divided into source- independent and dependent components, and the latter can be written in terms of three illustrative forms. For interferometers, complications arise from discrete sampling of synthesized apertures, but they can be overcome. POAM also manifests itself in the apodization of each telescope in an array. Holography of EVLA antennas observing a point source indicate that ~ 10% of photons in the n = 0 state are torqued to n != 0 states. Conclusions. POAM quantities represent excellent metrics for characterizing instruments because they are used to simultaneously describe amplitude and phase aberrations. In contrast, Zernike polynomials are just solutions of a differential equation that happen to ~ correspond to specific types of aberrations and are typically employed to fit only phases

Storming Majorana's Tower with OAM states of light in a plasma

We extend the relationship between mass and spin angular momentum, described by the bosonic spectrum of positive definite mass particles of the Majorana solution to the Dirac equation, to photons that acquire an effective Proca mass through the Anderson-Higgs mechanism when they propagate in a plasma. In an earlier paper we showed that if the plasma is structured, it can impart orbital angular momentum (OAM) to the photons that reduces the total Proca photon mass. Here we show, through a generalisation of Majorana's solution, that photons with OAM in a plasma cannot assume negative squared mass states. This means that there exist interesting analogies with Quantum Gravity or General Relativity models involving a modified action of the Lorentz group.Comment: 4 pages; Corrected, updated versio

Mycobacterium tuberculosis Drives Expansion of Low-Density Neutrophils Equipped With Regulatory Activities

In human tuberculosis (TB) neutrophils represent the most commonly infected phagocyte but their role in protection and pathology is highly contradictory. Moreover, a subset of low-density neutrophils (LDNs) has been identified in TB, but their functions remain unclear. Here, we have analyzed total neutrophils and their low-density and normal-density (NDNs) subsets in patients with active TB disease, in terms of frequency, phenotype, functional features, and gene expression signature. Full-blood counts from Healthy Donors (H.D.), Latent TB infected, active TB, and cured TB patients were performed. Frequency, phenotype, burst activity, and suppressor T cell activity of the two different subsets were assessed by flow cytometry while NETosis and phagocytosis were evaluated by confocal microscopy. Expression analysis was performed by using the semi-quantitative RT-PCR array technology. Elevated numbers of total neutrophils and a high neutrophil/lymphocyte ratio distinguished patients with active TB from all the other groups. PBMCs of patients with active TB disease contained elevated percentages of LDNs compared with those of H.D., with an increased expression of CD66b, CD33, CD15, and CD16 compared to NDNs. Transcriptomic analysis of LDNs and NDNs purified from the peripheral blood of TB patients identified 12 genes differentially expressed: CCL5, CCR5, CD4, IL10, LYZ, and STAT4 were upregulated, while CXCL8, IFNAR1, NFKB1A, STAT1, TICAM1, and TNF were downregulated in LDNs, as compared to NDNs. Differently than NDNs, LDNs failed to phagocyte live Mycobacterium tuberculosis (M. tuberculosis) bacilli, to make oxidative burst and NETosis, but caused significant suppression of antigen-specific and polyclonal T cell proliferation which was partially mediated by IL-10. These insights add a little dowel of knowledge in understanding the pathogenesis of human TB

Landscape composition predicts the distribution of Philaenus spumarius, vector of Xylella fastidiosa, in olive groves

The meadow spittlebug, Philaenus spumarius (Hemiptera: Aphrophoridae; Linnaeus, 1758), is considered the main vector in the ongoing Xylella fastidiosa outbreak in the olive groves of southern Italy. Identifying the factors driving the spatial distribution of P. spumarius is of primary importance to determine X. fastidiosa infection risk in healthy olive groves. Here, we investigated the local and landscape factors shaping the occurrence and abundance of P. spumarius by sampling 182 olive groves over 2 years in the Abruzzo region. We found the occurrence and abundance of the vector to be positively associated with the proportion of olive groves in the landscape and negatively with the cover of vineyards. Philaenus spumarius best responded to landscape processes at small spatial scale (125\u2013250 m) confirming the available information regarding its dispersal ability. At the local scale, soil management and pesticide application did not affect the vector probably because both interventions were not timed according to the vector biology and ecology. Our findings suggest that the management of agricultural landscape mosaics can drive the spatial distribution of P. spumarius. In particular, the landscape composition of the close surrounding of the olive groves may potentially influence the emergence probability of local X. fastidiosa epidemics through its effects on the vector spatial distribution and activity

Hydrodynamics and mass transfer in straight fiber bundles with non-uniform porosity

The present study investigates the effects of non-uniformity in a bundle's porosity by considering a model channel made up of "dense" (low porosity) and "loose" (high porosity) regions. In a first, simplified, approach these regions are treated as non-interacting porous media and previously obtained computational results are used for the Darcy permeability and the Sherwood number. In a second, and more complete, approach 3-D CFD simulations are conducted for a checkerboard arrangement of alternately "dense" and "loose" regions with square-arrayed fibers, accounting for entry effects and for interactions between regions. Non-uniformity causes a significant increase of the permeability and a strong reduction of the Sherwood number. These effects are larger, approaching those obtained for non-interacting regions, if the regions' length scale is large. The attainment of fully developed conditions is greatly shifted forward in non-uniform bundles and the mass transfer development length may largely exceed the physical length of most hollow-fiber devices

Valorization of surface-water RO brines via Assisted-Reverse Electrodialysis for minerals recovery: Performance analysis and scale-up perspectives

Reverse osmosis (RO) processes have been recently identified as mostly capable of quantitative removal of salts and contaminants from saline and surface waters, though posing the problem of a concentrated brine to be disposed of and a produced permeate too low in minerals, thus requiring a sometimes expensive remineralization step. In the present paper, Assisted-Reverse Electrodialysis (A-RED) has been proposed for the remineralization of surface-water RO permeate by recovering minerals from its brine. A purposely developed and validated model has been adopted to carry out a parametric analysis for design and optimization of an industrial-scale plant. The techno-economic analysis underlined that full permeate remineralization can be achieved with minimum specific energy consumption of 0.08 kWh m(-3), while a minimum remineralization cost of 2.2 c(sic) m(-3) was found applying a permeate by-pass and feed & bleed scheme to (i) increase the plant remineralization capacity and (ii) maintain a stack inlet conductivity above 100-160 mu S cm(-1) (starting from a permeate similar to 10 mu S cm(-1)). Compared to current post-treatment techniques, results appear very promising thanks to the reduction of chemicals and total costs as well as environmental concerns related to brine disposal

Performance Comparison of Alternative Hollow-Fiber Modules for Hemodialysis by Means of a CFD-Based Model

Commercial hemodialyzers are hollow-fiber cylindrical modules with dimensions and inlet– outlet configurations dictated mostly by practice. However, alternative configurations are possible, and one may ask how they would behave in terms of performance. In principle, it would be possible to depart from the standard counter-flow design, while still keeping high clearance values, thanks to the increase in the shell-side Sherwood number (Sh) due to the cross-flow. To elucidate these aspects, a previously developed computational model was used in which blood and dialysate are treated as flowing through two interpenetrating porous media. Measured Darcy permeabilities and mass transfer coefficients derived from theoretical arguments and CFD simulations conducted at unit-cell scale were used. Blood and dialysate were alternately simulated via an iterative strategy, while appropriate source terms accounted for water and solute exchanges. Several module configurations sharing the same membrane area, but differing in overall geometry and inlet–outlet arrangement, were simulated, including a commercial unit. Although the shell-side Sherwood number increased in almost all the alternative configurations (from 14 to 25 in the best case), none of them outperformed in terms of clearance the commercial one, approaching the latter (257 vs. 255 mL/min) only in the best case. These findings confirmed the effectiveness of the established commercial module design for the currently available membrane properties

A pilot-plant for the selective recovery of magnesium and calcium from waste brines

The problem of brines disposal has raised great interest towards new strategies for their valorisation through the recovery of minerals or energy. As an example, the spent brine from ion exchange resins regeneration is often discharged into rivers or lakes, thus impacting on the process sustainability. However, such brines can be effectively reconcentrated, after removal of bivalent cations, and reused for the resins regeneration. This work focuses on developing and testing a pilot plant for selective recovery of magnesium and calcium from spent brines exploiting a novel proprietary crystallization unit. This is part of a larger treatment chain for the complete regeneration of the brine, developed within the EU-funded ZERO BRINE project. The pilot crystallizer was tested with the retentate of the nanofiltration unit processing the spent brine from the industrial water production plant of Evides Industriewater B.V. (Rotterdam, The Netherlands). Magnesium and calcium hydroxide were selectively precipitated by adding alkaline solution in two consecutive steps and controlling reaction pH. Performance was assessed in terms of recovery efficiency and purity of produced crystals, observing in most investigated cases a recovery of about 100% and 97% and a purity above 90% and 96%, for magnesium and calcium hydroxide, respectively

Influence of bundle porosity on shell-side hydrodynamics and mass transfer in regular fiber arrays: A computational study

CFD predictions of the effects of a fiber bundle porosity on shell-side hydrodynamics and mass transfer under conditions of steady laminar flow were obtained. Fluid was assumed to flow around regular hexag-onal or square arrays of cylindrical fibers of different pitch to diameter ratios, yielding bundle porosities ranging from the theoretical minimum up to similar to 1. A large number of axial, transverse and mixed flow combinations were simulated by letting the axial and transverse flow Reynolds numbers and the trans-verse flow attack angle vary. Both fully developed and developing conditions (entrance effects) were con-sidered. The continuity and momentum equations, along with a transport equation for the concentra-tion of a high-Schmidt number solute, were solved by a finite volume CFD code. Fully developed condi-tions were simulated by the well-established "unit cell" approach, in which the computational domain is two-dimensional and includes a single fiber with the associated fluid, periodic boundary conditions are imposed between all opposite sides and compensative terms are introduced to account for large-scale longitudinal or transversal gradients. Developing flow was studied by using a fully three-dimensional computational domain. Predictions were validated against experimental, computational and analytic liter-ature results. The simulations showed that lattices with different porosities exhibit a qualitatively similar behavior, but differ significantly in important quantities such as the Darcy permeability, the Sherwood number and the hydrodynamic and mass transfer development length

Reconstruction of Acinetobacter johnsonii ICE_NC genome using hybrid de novo genome assemblies and identification of the 12α-hydroxysteroid dehydrogenase gene

Aims: The role of a Acinetobacter johnsonii strain, isolated from a soil sample, in the biotransformation of bile acids (BAs) was already described but the enzymes responsible for these transformations were only partially purified and molecularly characterized. Methods and Results: This study describes the use of hybrid de novo assemblies, that combine long-read Oxford Nanopore and short-read Illumina sequencing strategies, to reconstruct the entire genome of A. johnsonii ICE_NC strain and to identify the coding region for a 12α-hydroxysteroid dehydrogenase (12α-HSDH), involved in BAs metabolism. The de novo assembly of the A. johnsonii ICE_NC genome was generated using Canu and Unicycler, both strategies yielded a circular chromosome of about 3.6 Mb and one 117 kb long plasmid. Gene annotation was performed on the final assemblies and the gene for 12α-HSDH was detected on the plasmid. Conclusions: Our findings illustrate the added value of long read sequencing in addressing the challenges of whole genome characterization and plasmid reconstruction in bacteria. These approaches also allowed the identification of the A. johnsonii ICE_NC gene for the 12α-HSDH enzyme, whose activity was confirmed at the biochemical level. Significance and impact or the study: At present, this is the first report on the characterization of a 12α-HSDH gene in an A. johnsonii strain able to biotransform cholic acid into ursodeoxycholic acid, a promising therapeutic agent for several diseases. © 2022 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of Society for Applied Microbiology