High Resolution BIMA Observations of CO, HCN, and 13CO in NGC 1068

We present high-resolution CO, HCN, and 13CO maps of the inner arcminute of NGC 1068 made with the BIMA interferometer. Several features appear in the CO map which have not previously been observed: (1) a firm detection of CO line emission from a compact region centered on the nucleus of the galaxy; (2) the detection of a triplet velocity structure characteristic of kinematically independent regions shown on the spectrum of the unresolved nuclear emission ; and (3) the detection of a molecular bar, the extent and position angle of which are in good agreement with the 2 $\mu$m stellar bar. The most intense CO emission is nonnuclear; the structure and kinematics of this emission imply that this gas is distributed along the inner spiral arms and not in a ring. The bar's kinematic influence on the molecular gas in the spiral arms is modest, with typical ordered noncircular motions of \la\ 30 \kms\ in the plane of the galaxy. Interior to the spiral arms, the bar's influence is more dramatic, as reflected by the twisted isovelocity contours in the CO and HCN velocity fields. The surface density of molecular gas within the central 100 pc radius of NGC 1068 is the same as that in the central 200 pc radius in the Milky Way to within the uncertainties. There is evidence for an $m= 1$ kinematic mode in NGC 1068; we find the kinematic center of rotation to be displaced from the radio continuum center by about 2.9", or 200 pc. The HCN image, in contrast to the CO map, shows a strong concentration of emission centered on the nucleus. The ratio of integrated intensities of the HCN emission to that of CO is about 0.6 and is the highest ratio measured in the central region of any galaxy.Comment: 35 pages of uuencoded, compressed postscript, 20 postscript figures not included but available from [email protected] or from ftp://astro.astro.umd.edu/pub/thelfer/n1068_figs.ps.Z To appear in The Astrophysical Journal, V. 450, Sept. 199

Information Model of Cloud App Scaling with Variable Load Peaks

The information model of cloud app was done. It is a formal description of cloud app infrastructure and possible transitions between them, and cloud app current working state classification criterion. Cloud app current state classification criterion on the basis of Page-Hinckley method and calendar of events related to the cloud app working state considers the current state to one of three classes in order to improve the accuracy of prediction of cloud app workload.Proposed criterion was compared with standard offline criterion that analyzes information about the entire time series of cloud app through a considerable time after the events that lead to the load peak, and therefore can\u27t be used when grading in real time. It is shown that the classification of cloud app state is consistent in 92 % of cases.The resulting information model of cloud app scaling with variable load peaks can be used as a component of information technology for cloud app scaling with variable load peaks

Research of Motivational Aspects for Marketing Support of Innovative Activity of Industrial Enterprises

The article is devoted to the theoretical grounding and development of practical recommendations for research and formation of motivational aspects for marketing support of innovative activity of industrial enterprises. Methodology of the research of marketing employees at industrial enterprises is revealed to clarify the motives of their behavior and the impact on existing businesses activity. Use of internal marketing is proposed to enhance the motivation of marketing employees for improving innovative activity of the enterprises. Application of motivational approach of the internal marketing is proved. This application is based on overcoming objections concerning innovation, study of internal incentives and opportunities for self-development and aims to result in a change and/or innovation, which is achieved through the formation of a balanced scorecard of marketing department, which is provides creation of preconditions to stimulate, support and development of innovation. Scientific and practical approaches are developed for the use of a balanced scorecard to determine sub-processes of marketing activities, as well as in assessing loyalty of the marketing employees

Dense Gas in the Milky Way

We present a study of dense gas emission in the Milky Way in order to serve as a basis for comparison with extragalactic results. This study combines new observations of HCN, CS, and CO in individual GMCs and in the Milky Way plane with published studies of emission from these molecules in the inner 500 pc of the Milky Way. We find a strong trend in the fraction of emission from dense gas tracers as a function of location in the Milky Way: in the bulge, I_{HCN}/I_{CO} = 0.081 \pm 0.004, in the plane, I_{HCN}/I_{CO} = 0.026 \pm 0.008 on average, and over the full extent of nearby GMCs, I_{HCN}/I_{CO} = 0.014 \pm 0.020. Similar trends are seen in I_{CS}/I_{CO}. The low intensities of the HCN and CS emission in the plane suggests that these lines are produced by gas at moderate densities; they are thus not like the emission produced by the dense, pc-scale star forming cores in nearby GMCs. The contrast between the bulge and disk ratios in the Milky Way is likely to be caused by a combination of higher kinetic temperatures as well as a higher dense gas fraction in the bulge of the Milky Way.Comment: 34 pages LaTeX, AASTEX macros, includes 11 postscript figures. To appear in ApJ 478, March 199

Ecological optimum of ectothermic organisms: static-dynamical approach

During 20th century the majority of researchers interpreted ecological optimum as a certain combination of ambient factors which is optimal for growth, existence and reproduction of an organism. However, it was revealed in many species, that the maximum rates of various processes in an organism are achieved at various combinations of values of different factors, and under variable regimes as opposite to constant regimes. One may state that there is no well defined general concept which takes into account a bulk of data that do not conform the traditional definition of ecological optimum. Here, we show that it is necessary to make distinction between concepts of "static" and "dynamic" optima. It is needed for definition of real ecological optimum and creation of optimum conditions for given factor. We show also that it is necessary to take into account so-called delayed effects of factors. Basing on the analysis of responses of zooplankton to various temperatures and phosphoric load, we show that an optimum has "dynamic" characteristics besides previously known "static" ones, like a range of factor values on tolerance curve or a doze of factor. These "dynamic" characteristics are cyclic and stepwise changes of a factor, a directionality of factor's dynamics in case of stepwise changes and additionally, we reveal stimulating and inhibiting delayed effects of factors. Our results allow for a more detailed concept of ecological optimum, and also may stimulate investigations of quantitative contribution of various parameters of environmental factors to an ecological optimum of an organism or population

Non-empirical nuclear energy functionals, pairing gaps and odd-even mass differences

First, we briefly outline some aspects of the starting project to design non-empirical energy functionals based on low-momentum vacuum interactions and many-body perturbation theory. Second, we present results obtained within an approximation of such a scheme where the pairing part of the energy density functional is constructed at first order in the nuclear plus Coulomb two-body interaction. We discuss in detail the physics of the odd-even mass staggering and the necessity to compute actual odd-even mass differences to analyze it meaningfully.Comment: 8 pages, 1 figure, proceedings of the International Conference on Nuclear Structure and Dynamics, Dubrovnik, Croatia, May 4 - 8, 200

FLUOXETINE ATTENUATES MAST CELL FUNCTION BY TARGETING PURINERGIC SIGNALING

Mast cells are tissue resident, innate immune cells that provide protection against parasitic and bacterial infections and venom poisoning. Mast cells also play a pathogenic role in atopy and allergic diseases. Atopy and allergic diseases are increasing in the developed world and are predicted to continue to increase at an alarming rate. Current treatment options include corticosteroids, anti-histamines, anti-IgE and avoidance of allergen. These interventions have limitations: some patients are steroid resistant; anti-histamines have low efficacy since they need to be administered early during allergen exposure; and anti-IgE is costly. Thus there is a clinical need for new treatment options. An efficient approach is to re-purpose FDA-approved drugs. Selective serotonin reuptake inhibitors (SSRIs) are a class of anti-depressants used to treat depression and other psychiatric disorders. SSRIs have been shown to possess anti-inflammatory properties, but the mechanism of action is unclear. The possibility to treat allergic diseases with SSRIs has not been studied. Using primary mouse bone marrow derived, ex vivo cultured mouse peritoneal, and primary skin derived human mast cells, we show that the SSRI fluoxetine suppresses IgE-mediated degranulation, cytokine production, and inflammatory lipid secretion. Several other SSRIs showed similar effects on mouse mast cells. Cytokine suppression occurs at a transcriptional level, as evidenced by decreased signaling downstream of the IgE receptor and reduced cytokine mRNA induction. We found that fluoxetine-mediated suppression requires the purinergic receptor, P2X3. Furthermore, we show that IgE stimulation elicits rapid ATP release from mast cells, and that ATP and purinergic signaling is a positive feedback regulator of mast cell activation. Fluoxetine can also suppress ATP-mediated cytokine production, degranulation, and lipid production most likely via NFkb suppression and diminished purinergic receptor expression. Importantly, fluoxetine effects are consistent in an in vivo passive systemic anaphylaxis (PSA) model and in a house dust mite (HDM) airway hyperresponsiveness and lung inflammation model of asthma. In the PSA model, fluoxetine reduced hypothermia and cytokine production. In the asthma model, the drug suppressed bronchoresponsiveness as well as pulmonary mast cell hyperplasia and eosinophilia, and the recruitment of Th2 cells, neutrophils, eosinophils, and lymphocytes to the bronchoalveolar space, as well as cytokine levels in the bronchoalveolar fluid in sensitized mice. Overall, we show that fluoxetine broadly suppresses mast cell activation in vitro and in vivo, most likely by impeding an ATP-P2X3 positive feedback loop

Smad4 regulates growth plate matrix production and chondrocyte polarity.

Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints. The TGFβ pathway also plays a critical role in the development, organization and proliferation of the growth plate, although the exact mechanisms remain unclear. Skeletal phenotypes in Myhre syndrome overlap with processes regulated by the TGFβ pathway, including organization and proliferation of the growth plate and polarity of the chondrocyte. We used in vitro and in vivo models of Smad4 deficiency in chondrocytes to test the hypothesis that deregulated TGFβ signaling leads to aberrant extracellular matrix production and loss of chondrocyte polarity. Specifically, we evaluated growth plate chondrocyte polarity in tibiae of Col2-Cre+/-;Smad4fl/fl mice and in chondrocyte pellet cultures. In vitro and in vivo, Smad4 deficiency decreased aggrecan expression and increased MMP13 expression. Smad4 deficiency disrupted the balance of cartilage matrix synthesis and degradation, even though the sequential expression of growth plate chondrocyte markers was intact. Chondrocytes in Smad4-deficient growth plates also showed evidence of polarity defects, with impaired proliferation and ability to undergo the characteristic changes in shape, size and orientation as they differentiated from resting to hypertrophic chondrocytes. Therefore, we show that Smad4 controls chondrocyte proliferation, orientation, and hypertrophy and is important in regulating the extracellular matrix composition of the growth plate