4,011 research outputs found

    A sandpile model with tokamak-like enhanced confinement phenomenology

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    Confinement phenomenology characteristic of magnetically confined plasmas emerges naturally from a simple sandpile algorithm when the parameter controlling redistribution scalelength is varied. Close analogues are found for enhanced confinement, edge pedestals, and edge localised modes (ELMs), and for the qualitative correlations between them. These results suggest that tokamak observations of avalanching transport are deeply linked to the existence of enhanced confinement and ELMs.Comment: Manuscript is revtex (latex) 1 file, 7 postscript figures Revised version is final version accepted for publication in PRL Revisions are mino

    IRE1ÎČ negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

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    IRE1ÎČ is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1ÎČ have an attenuated unfolded protein response to ER stress. When modeled in HEK293 cells and with purified protein, IRE1ÎČ diminishes expression and inhibits signaling by the closely related stress sensor IRE1α. IRE1ÎČ can assemble with and inhibit IRE1α to suppress stress-induced XBP1 splicing, a key mediator of the unfolded protein response. In comparison to IRE1α, IRE1ÎČ has relatively weak XBP1 splicing activity, largely explained by a nonconserved amino acid in the kinase domain active site that impairs its phosphorylation and restricts oligomerization. This enables IRE1ÎČ to act as a dominant-negative suppressor of IRE1α and affect how barrier epithelial cells manage the response to stress at the host–environment interface

    Arase Observation of the Source Region of Auroral Arcs and Diffuse Auroras in the Inner Magnetosphere

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    Auroral arcs and diffuse auroras are common phenomena at high latitudes, though characteristics of their source plasma and fields have not been well understood. We report the first observation of fields and particles including their pitch‐angle distributions in the source region of auroral arcs and diffuse auroras, using data from the Arase satellite at L ~ 6.0–6.5. The auroral arcs appeared and expanded both poleward and equatorward at local midnight from ~0308 UT on 11 September 2018 at Nain (magnetic latitude: 66°), Canada, during the expansion phase of a substorm, while diffuse auroras covered the whole sky after 0348 UT. The top part of auroral arcs was characterized by purple/blue emissions. Bidirectional field‐aligned electrons with structured energy‐time spectra were observed in the source region of auroral arcs, while source electrons became isotropic and less structured in the diffuse auroral region afterwards. We suggest that structured bidirectional electrons at energies below a few keV were caused by upward field‐aligned potential differences (upward electric field along geomagnetic field) reaching high altitudes (~30,000 km) above Arase. The bidirectional electrons above a few keV were probably caused by Fermi acceleration associated with the observed field dipolarization. Strong electric‐field fluctuations and earthward Poynting flux were observed at the arc crossing and are probably also caused by the field dipolarization. The ions showed time‐pitch‐angle dispersion caused by mirror reflection. These results indicate a clear contrast between auroral arcs and diffuse auroras in terms of source plasma and fields and generation mechanisms of auroral arcs in the inner magnetosphere

    A side-by-side comparison of Daya Bay antineutrino detectors

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    The Daya Bay Reactor Neutrino Experiment is designed to determine precisely the neutrino mixing angle Ξ13\theta_{13} with a sensitivity better than 0.01 in the parameter sin22Ξ13^22\theta_{13} at the 90% confidence level. To achieve this goal, the collaboration will build eight functionally identical antineutrino detectors. The first two detectors have been constructed, installed and commissioned in Experimental Hall 1, with steady data-taking beginning September 23, 2011. A comparison of the data collected over the subsequent three months indicates that the detectors are functionally identical, and that detector-related systematic uncertainties exceed requirements.Comment: 24 pages, 36 figure

    Observation of electron-antineutrino disappearance at Daya Bay

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    The Daya Bay Reactor Neutrino Experiment has measured a non-zero value for the neutrino mixing angle Ξ13\theta_{13} with a significance of 5.2 standard deviations. Antineutrinos from six 2.9 GWth_{\rm th} reactors were detected in six antineutrino detectors deployed in two near (flux-weighted baseline 470 m and 576 m) and one far (1648 m) underground experimental halls. With a 43,000 ton-GW_{\rm th}-day livetime exposure in 55 days, 10416 (80376) electron antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to expected number of antineutrinos at the far hall is R=0.940±0.011(stat)±0.004(syst)R=0.940\pm 0.011({\rm stat}) \pm 0.004({\rm syst}). A rate-only analysis finds sin⁥22Ξ13=0.092±0.016(stat)±0.005(syst)\sin^22\theta_{13}=0.092\pm 0.016({\rm stat})\pm0.005({\rm syst}) in a three-neutrino framework.Comment: 5 figures. Version to appear in Phys. Rev. Let
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