Church in the apostolic spirit: a strategy for building indigenous apostolic congregations in the cultural context of Eastern Orthodox and post-Communist Romania

https://place.asburyseminary.edu/ecommonsatsdissertations/1710/thumbnail.jp

Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures

Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA receptors in the perinatal period. The most common cause of neonatal seizures is hypoxic encephalopathy, and here we show in an established model of neonatal hypoxia-induced seizures that the NKCC1 inhibitor, bumetanide, in combination with phenobarbital is significantly more effective than phenobarbital alone. A sensitive mass spectrometry assay revealed that bumetanide concentrations in serum and brain were dose-dependent, and the expression of NKCC1 protein transiently increased in cortex and hippocampus after hypoxic seizures. Importantly, the low doses of phenobarbital and bumetanide used in the study did not increase constitutive apoptosis, alone or in combination. Perforated patch clamp recordings from ex vivo hippocampal slices removed following seizures revealed that phenobarbital and bumetanide largely reversed seizure-induced changes in EGABA. Taken together, these data provide preclinical support for clinical trials of bumetanide in human neonates at risk for hypoxic encephalopathy and seizures

Live it! - An Interactive non-linear adventure

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Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required

Sociology of tourism

"La sociologie du tourisme. Le tourisme, en tant que phénomène de masse,n’apparaît qu’au début du 19e siècle. Bien que sa période moderne de développement soit courte, le tourisme a connu beaucoup de transformations allant du tourisme balnéaire au tourisme culturel et industriel. À présent, le tourisme se définit sous trois aspects interdépendants : comme ressource, élément de dangerosité et phénomène social. En tant que ressource durable ayant une valeur de marché, le tourisme représente une opportunité de développement régional. En outre, l’impact du tourisme sur la société peut se transformer en un élément de dangerosité dont les effets seront ressentis à long terme. En tant que phénomène social, le tourisme peut devenir un prétexte de socialisation, une alternative au quotidien, un moyen d’éducation. Sous aspect ethnique, le tourisme peut perpétuer ou aggraver les conflits interculturels. Au niveau de chaque individu le tourisme est perçu de manière subjective.

"Zwangskammerstaat"?: Zur Demokratiequalität der Sozialpartnerschaft

Abstract: How can we judge the democratic quality of Austrian neo-corporatism ("Kammersystem") and cooperative decision making ("Sozialpartnerschaft")? The paper develops three main hypotheses. First, internal democracy within the existing centralized interest groups is fairly low while the practice of tripartite concertation between labour, business and state representatives is not democratically legitimized at all. Second, the general public expresses manifest discontent with present interestorganizations while still valuing positively their policy style of cooperative as well as secretive elite bargaining. Thus, degrees of public approval are apparently unrelated to degrees of democratic legitimation. Third, if they want to survive Austrian chambers of labor and business will have to adopt innovative strategies to increase both formal and material legitimation.