Les urgences en odontologie chez l'adulte sain, au CHU de Reims

REIMS-BU Santé (514542104) / SudocSudocFranceF

Activités du groupe d'Archéologie classique de l'Université de Lille-III en 1972

De La Genière Juliette, Quivron Gonzague, Jelski Georges, Lebrun A., Vermersch A., Martial Christine, Gernez Annick, Desreumaux Isabelle, Bescond Annie, Leblon Marie-Ange, Van Hoeke Nicole, Florin Isabelle, Deblock G., Talleux D., Bouillet M. F., Cellerier M. V. Activités du groupe d'Archéologie classique de l'Université de Lille-III en 1972. In: Revue du Nord, tome 55, n°216, Janvier-mars 1973. pp. 53-59

Activités du groupe d'Archéologie classique de l'Université de Lille-III en 1972

De La Genière Juliette, Quivron Gonzague, Jelski Georges, Lebrun A., Vermersch A., Martial Christine, Gernez Annick, Desreumaux Isabelle, Bescond Annie, Leblon Marie-Ange, Van Hoeke Nicole, Florin Isabelle, Deblock G., Talleux D., Bouillet M. F., Cellerier M. V. Activités du groupe d'Archéologie classique de l'Université de Lille-III en 1972. In: Revue du Nord, tome 55, n°216, Janvier-mars 1973. pp. 53-59

Rapid Improvement after Starting Elexacaftor–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and Advanced Pulmonary Disease

International audienceRationale: Elexacaftor-tezacaftor-ivacaftor is a CFTR (cystic fibrosis [CF] transmembrane conductance regulator) modulator combination, developed for patients with CF with at least one Phe508del mutation. Objectives: To evaluate the effects of elexacaftor-tezacaftor- ivacaftor in patients with CF and advanced respiratory disease. Methods: A prospective observational study, including all patients aged ⩾12 years and with a percent-predicted FEV1 (ppFEV1) <40 who initiated elexacaftor-tezacaftor-ivacaftor from December 2019 to August 2020 in France was conducted. Clinical characteristics were collected at initiation and at 1 and 3 months. Safety and effectiveness were evaluated by September 2020. National-level transplantation and mortality figures for 2020 were obtained from the French CF and transplant centers and registries. Measurements and Main Results: Elexacaftor-tezacaftor- ivacaftor was initiated in 245 patients with a median (interquartile range) ppFEV1 = 29 (24-34). The mean (95% confidence interval) absolute increase in the ppFEV1 was +15.1 (+13.8 to +16.4; P < 0.0001), and the mean (95% confidence interval) in weight was +4.2 kg (+3.9 to +4.6; P < 0.0001). The number of patients requiring long-term oxygen, noninvasive ventilation, and/or enteral tube feeding decreased by 50%, 30%, and 50%, respectively (P < 0.01). Although 16 patients were on the transplant waiting list and 37 were undergoing transplantation evaluation at treatment initiation, only 2 received a transplant, and 1 died. By September 2020, only five patients were still on the transplantation path. Compared with the previous 2 years, a twofold decrease in the number of lung transplantations in patients with CF was observed in 2020, whereas the number of deaths without transplantation remained stable. Conclusions: In patients with advanced disease, elexacaftor-tezacaftor-ivacaftor is associated with rapid clinical improvement, often leading to the indication for lung transplantation being suspended