Multiple myeloma presenting as CEA-producing rectal cancer

We report the case of a 57-year-old patient with multiple myeloma, characterized by extramedullary involvement of the rectum at presentation. Malignant plasma cells were found to produce carcinoembryonic antigen (CEA), a tumor antigen more commonly associated with rectal adenocarcinomas

CARACTERIZACI 3N CL\ucdNICA, ANGIOGR\uc1FICA E INTERVENCIONISTA DE LA ENFERMEDAD ARTERIAL CORONARIA EN PACIENTES DIAB\uc9TICOS. SERVICIO DE HEMODINAMIA. CENTRO CARDIOVASCULAR REGIONAL. ASCARDIO. BARQUISIMETO. ESTADO LARA

Este estudio tiene como objetivo caracterizar de forma cl\uednica, angiogr\ue1fica e intervencionista, la enfermedad arterial coronaria en pacientes diab\ue9ticos tratados en el Servicio de Hemodinamia del CCR ASCARDIO Barquisimeto Estado Lara en el periodo comprendido entre 2012 - 2014. Como parte de la metodolog\ueda, previa autorizaci\uf3n por la direcci\uf3n de la Instituci\uf3n, se obtuvo el registro a trav\ue9s de las historias cl\uednica de los pacientes, luego se procesaron los datos obtenidos para describir las caracter\uedsticas y la interpretaci\uf3n de los mismos. Dentro de los resultados obtenidos, El 55% de los pacientes eran del sexo masculino, con promedio de edad de 62 \ub1 9 a\uf1os. La CIC se encontr\uf3 en el 92,5% de los pacientes, el 91,4% con HTA, 60,2% con dislipidemia y tabaquismo 47,8%, el 7,5% acudieron por presentar SCA, de los cuales el 65% fue SCASEST y 35% SCACEST. El abordaje femoral fue el m\ue1s utilizado en un 59%, con lesiones tipo B de mayor predominancia (48%), en 11% de los casos se evidenci\uf3 la presencia de trombos. De las complicaciones inmediatas relacionada con el \ue1rbol coronario, el flujo lento fue lo m\ue1s frecuente en un 42% y menos frecuente fue la perdida de rama en un 5%. El hematoma fue la complicaci\uf3n inmediata local m\ue1s frecuente 39%, la muerte ocurri\uf3 en 1 paciente (0,5%). La hiperglicemia se evidencio en un 36% de los pacientes. Con todo lo presentado se concluye que las caracter\uedsticas cl\uednicas, angiogr\ue1ficas e intervencionistas de la enfermedad arterial coronaria en pacientes diab\ue9ticos tratados en el Servicio de Hemodinamia del CCR ASCARDIO son muy similares a la del resto de los pacientes encontrados en los antecedentes de nuestra investigaci\uf3n. PALABRAS CLAVE: Diabetes mellitus. Enfermedad arterial coronaria. ABSTRACT The present study aims to characterize, in a clinical, angiographic and interventional manner, coronary artery disease in diabetic patients treated in the Hemodynamic Service of CCR ASCARDIO Barquisimeto State of Lara in the period between 2012 -2014. As part of the methodology, after authorization by the institution's management as well the hemodynamic service, the registry was obtained through the clinical histories of the patients studied, and the data obtained to describe these characteristics and their interpretation were subsequently processed. Within the results obtained 55% of the patients were males, with a mean age of 62 \ub1 9 years. The ICC was found in 92.5% of patients, 91.4% with AHT, followed by 60.2% with dyslipidemia and 47.8% in smoking, while 7.5% came for presenting SCA, of which 65% was NSTEACS and 35% ESTMI. The femoral approach was the most used in 59%, followed by the radial approach in 41%, with lesions type B of greater predominance (48%), in 11% of the cases the presence of thrombi was evidenced. Of the immediate complications related to the coronary tree, slow flow was the most frequent in 42% and the least frequent was branch loss in 5%. Hematoma was the most frequent immediate local complication in 39%, followed by bleeding and pseudoaneurysms with 15% each, death occurred only in 1 patient (0.5%). Hyperglycemia was evident in 36% of patients. With everything presented above it is concluded, the clinical, angiographic and interventional characteristics of coronary artery disease in diabetic patients treated in the Hemodynamic Service of the CCR ASCARDIO are very similar to the rest of the patients found in the background of our investigation. KEY WORDS: Diabetes mellitus. Coronary artery disease.<br

Rediscovering Cova de la Sarsa (València, Spain): a Multidisciplinary Approach to One of the Key Early Neolithic Sites in the Western Mediterranean

Cova de la Sarsa (València, Spain) is one of the most important Neolithic impressed ware culture archaeological sites in the Western Mediterranean. It has been widely referenced since it was excavated in the 1920s, due partly to the relatively early excavation and publication of the site, and partly to the qualitative and quantitative importance of its archaeological remains. Unfortunately, as it was an older excavation and lacked present-day rigorous methodological approaches, this important site has been somewhat relegated to the background in the reviews about the Neolithic at the end of the 20th century. However, during the last few years, both the site itself and its archaeological remains have been the object of new studies that hopefully will return the site to the forefront of discussions about the Mediterranean Neolithic. We here present the most relevant results of the research carried out by our group (i.e., pottery study, radiocarbon dating, and isotope analysis), and contextualize them within the dense research history of the cave and the studies carried out by other colleagues with the purpose of revisiting its materials and increasing the knowledge available from the site. Radiocarbon dates on human remains show that the cave was used during prehistoric times as a funerary space longer than expected, and also sporadically afterwards. The characterization of the pottery assemblage concludes that most materials belong to the Early Neolithic. Isotopic analysis portrays an overall similar diet based on terrestrial C3 resources throughout prehistoric times, with a possible varied dietary protein input between individuals during the Early Neolithic

New process for the production of permeate powders without spray dryer

An innovative process scheme for the production of dairy permeate powders was tested at the pilot scale. It includes: (i) overconcentration of the permeate concentrate from 60 to 80% w/w dry matter (DM) content; (ii) granulation of the overconcentrate with powder up to 88% DM; and (iii) drying of the granules up to 97% DM.The quality of the resulting powder was comparable to a standard powder produced using conventional technologies. Furthermore, considering energy required for water removal, the new process led to significant savings: they were estimated in the range of 10.7 to 23.5% and up to 32% when taking into account the whole production process or the drying step alone, respectively

Use of combinations of antipsychotics: McLean Hospital inpatients, 2002

Background The empirical use of combinations of antipsychotic agents appears to be increasing with little research support for the relative efficacy, safety or cost-effectiveness of this practice. Such treatment was evaluated in hospitalized psychiatric patients. Methods Samples of consecutive inpatients treated with > 2 ('polytherapy') vs 1 antipsychotic ('monotherapy') were matched on age, sex, diagnosis and admission clinical ratings, and these groups were compared on total daily chlorpromazine-equivalent doses, days in hospital, and changes in clinical ratings between admission and discharge. Results The study sample included 69 polytherapy and 115 well-matched monotherapy subjects. Despite matching for initial CGI and GAF ratings, polytherapy was associated with high PANSS subscale scores of positive symptoms among affective psychosis, and relatively greater PANSS subscale ratings of excitement-agitation among patients diagnosed with schizophrenia. Estimated clinical improvement during hospitalization was similar among poly- and monotherapy patients, but total daily CPZ-eq doses at discharge averaged twice-greater with polytherapy, and hospitalization lasted 1.5 times longer. Conclusions Antipsychotic polytherapy as well as the types of agents combined may reflect clinician responses to particular symptom patterns. The value of specific combinations of antipsychotic agents and their comparison with monotherapies requires specific, prospective, randomized and well-controlled trials that consider matching on clinical characteristics and truly comparable doses across regimens. Copyright (c) 2005 John Wiley & Sons, Ltd

The new 14C chronology for the Palaeolithic site of La Ferrassie, France: the disappearance of Neanderthals and the arrival of Homo sapiens in France

The grand abri at La Ferrassie (France) has been a key site for Palaeolithic research since the early part of the 20th century. It became the eponymous site for one variant of Middle Palaeolithic stone tools, and its sequence was used to define stages of the Aurignacian, an early phase of the Upper Palaeolithic. Several Neanderthal remains, including two relatively intact skeletons, make it one of the most important sites for the study of Neanderthal morphology and one of the more important data sets when discussing the Neanderthal treatment of the dead. However, the site has remained essentially undated. Our goal here is to provide a robust chronological framework of the La Ferrassie sequence to be used for broad regional models about human behaviour during the late Middle to Upper Palaeolithic periods. To achieve this goal, we used a combination of modern excavation methods, extensive geoarchaeological analyses, and radiocarbon dating. If we accept that Neanderthals were responsible for the Châtelperronian, then our results suggest an overlap of ca. 1600 years with the newly arrived Homo sapiens found elsewhere in France