Hepatocellular Carcinoma: correlations between Gadobenate Dimeglumine-enhanced Magnetic Resonance (MR) Imaging and pathological findings.

RATIONALE AND OBJECTIVES: To correlate the appearance of hepatocellular carcinoma on delayed (60 minutes) postcontrast T1-weighted gradient echo images with the mode of action of gadobenate dimeglumine (Gd-BOPTA) and the anatomic and pathologic characteristics of the lesions. METHODS: A total of 34 patients with hepatocellular carcinoma and varying degrees of diffuse liver disease were studied. T2-weighted spin echo and T1-weighted spin echo and gradient echo images were acquired before and 60 minutes after the intravenous administration of 0.1 mmol/kg Gd-BOPTA. Qualitative and quantitative evaluations of the images were performed and correlated with histologic findings. The quantitative evaluation, performed on T1-weighted gradient echo images, looked at the percentage increase of liver enhancement after Gd-BOPTA administration, the lesion-to-liver contrast/noise (C/N) ratio before and after Gd-BOPTA administration, and the C/N variation after Gd-BOPTA administration. Qualitative assessment considered the morphologic features of the lesions as well as the visual variation of contrast before and after Gd-BOPTA administration. Finally, a histologic evaluation was made of the degree of differentiation of the lesions and of the presence of fatty metaplasia, necrosis, bile, or intratumoral peliosis. RESULTS: Among the parameters affecting lesion identification were the extent of liver function, degree of vascularization, residual functionality of the tumor cells, and characteristics of the neoplastic tissue. Positive correlations (Spearman coefficients = 0.359 and 0.393, respectively) were observed precontrast between the degree of liver failure and the amount of contrast noise, and postcontrast between the amount of intralesional fatty metaplasia and the extent to which lesion conspicuity worsened after Gd-BOPTA administration. An inverse correlation (Spearman coefficient = -0.330) was observed between the degree of lesion differentiation and the visible appearance after Gd-BOPTA administration, with well-differentiated lesions tending toward worsened conspicuity postcontrast. A statistically significant difference (P = 0.001) was observed in the mean precontrast C/N ratio for lesions later showing unchanged conspicuity and worse conspicuity on postcontrast images, respectively. Marked variation (P = 0.019) was also observed between Child A and B cirrhotic patients for the degree of hepatic enhancement on postcontrast images. CONCLUSIONS: The results suggest that liver parenchyma signal intensity is influenced by the extent to which liver function is compromised, that residual hepatocytic functionality permits Gd-BOPTA uptake by certain lesions and that this uptake might subsequently impair the observed C/N ratio on delayed images, and that the worsening of lesion conspicuity on postcontrast images is influenced also by high quantities of intralesional fatty metaplasia

Dermoscopic diagnosis of amelanotic/hypomelanotic melanoma

20N/Apartially_openopenPizzichetta MA; Kittler H; Stanganelli I; Ghigliotti G; Corradin MT; Rubegni P; Cavicchini S; De Giorgi V; Bono R; Alaibac M; Astorino S; Ayala F; Quaglino P; Pellacani G; Argenziano G; Guardoli D; Specchio F; Serraino D; Talamini R; Italian Melanoma Intergroup (IMI)Pizzichetta, Ma; Kittler, H; Stanganelli, I; Ghigliotti, G; Corradin, Mt; Rubegni, P; Cavicchini, S; De Giorgi, V; Bono, R; Alaibac, M; Astorino, S; Ayala, F; Quaglino, P; Pellacani, G; Argenziano, G; Guardoli, D; Specchio, F; Serraino, D; Talamini, R; Italian Melanoma Intergroup, (IMI

Progresso da ferrugem do cafeeiro irrigado em diferentes densidades de plantio pós-poda Progress of rust in coffee plants in various densities of cultivation in irrigated planting after pruning

Objetivou-se, no presente trabalho, avaliar o efeito de diferentes critérios para manejo da irrigação em quatro densidades de plantio, sob sistema de gotejamento na incidência e severidade da ferrugem do cafeeiro e avaliar a influência do enfolhamento na curva de progresso dessa doença. Conduziu-se, o experimento, em área experimental da Universidade Federal de Lavras MG, utilizando a cultivar Rubi MG-1192 com seis anos. O delineamento experimental foi em blocos ao acaso com quatro repetições. Os tratamentos foram constituídos por quatro parcelas representadas pelas densidades de plantio (convencionais e adensados): 2500 (4,0x1,0 m), 3333 (3,0x1,0 m), 5000 (2,0x1,0 m), 10000 (2,0x0,5 m) plantas ha-1, quatro subparcelas sendo: irrigações quando a tensão da água no solo atingiu valores de 20 e 60kPa; irrigações utilizando o manejo do balanço hídrico (calculado através do software IRRIPLUS), com turnos de irrigação fixos de três dias por semana e uma testemunha sem irrigação, perfazendo um total de 16 tratamentos. Cada subparcela foi constituída por 10 plantas, sendo consideradas como plantas úteis as seis centrais. Foram avaliadas a incidência e severidade da ferrugem e a porcentagem de enfolhamento das plantas de cafeeiros. Após análise estatística, os dados foram convertidos em área abaixo da curva de progresso da doença e do crescimento. Verificou-se que os critérios para manejo da irrigação influenciaram a curva de progresso do crescimento, porém, não interferiu na curva de progresso da incidência e da severidade da ferrugem. Os sistemas de plantios adensados favoreceram a incidência da ferrugem. Mas as densidades de plantio não interferiram no enfolhamento.<br>The objective of this study was to evaluate the effect of different irrigation controls implemented in four planting densities on a system of drip on the incidence and severity of rust and to assess the influence of leaf growth on the progress curve of this disease. The experiment was conducted in the experimental area of the Federal University of Lavras - MG, using the cultivar Rubi MG-1192 with 6 years. The experimental design was randomized blocks with four replicates. The treatments consisted of four tranches represented by planting densities (conventional and non-conventional): 2500 (4.0 x1.0 m), 3333 (3.0 x 1.0 m), 5000 (2.0 x 1.0 m), 10,000 (2.0 x 0.5 m) plants / ha, with four subplots: the tension when irrigation water in the soil reaches values of 20 and 60kPa; using water balance management of irrigation (calculated by the software IRRIPLUS) with rounds of irrigation fixed three days per week and a control without irrigation, making a total of 16 treatments. Each subplot line consisted of 10 plants with the six central plants considered as useful. The incidence and severity of rust and the percentage of grown of coffee plants were evaluated. After statistical analyses the data were converted to area under the curve of disease and growth progress. It was verified that the management of irrigation influenced the progress curve of growth, but it did not interfere in the progress curve of the incidence and severity of coffee rust. The dense system of plantation favored the incidence of rust. However, the planting densities did not affect growth

MP5-16 QUALITY OF LIFE OF 171 PATIENTS WITH BLADDER CANCER UNDERGOING ILEAL ORTHOTOPIC NEOBLADDER: A MULTICENTRE STUDY AMONG LONG-TERM SURVIVORS

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