Superior Electrochemical Performance of a Ni-P/Si Negative Electrode for Li-ion Batteries in an Ionic Liquid Electrolyte

To achieve electrode performance with both high capacity and long cycle life, we investigated the effect of the anion structure in an ionic liquid electrolyte on the electrochemical performance of an annealed Ni-P/(etched Si) negative electrode for Li-ion batteries. The electrode maintained a discharge capacity of 1890 mA h g-1 after 250 cycles in bis(fluorosulfonyl)amide-based ionic liquid electrolyte, which was approximately three times higher than that in bis(trifluoromethanesulfonyl)amide-based electrolyte

Effect of Annealing Temperature of Ni-P/Si on its Lithiation and Delithiation Properties

Annealed Ni–P–coated Si (Ni–P/Si) anodes for lithium-ion batteries have shown a superior cycle life with discharge capacity of 1000 mA h g−1 over 1100 cycles in some ionic-liquid electrolytes. However, the annealing temperature has yet to be optimized for Ni–P/Si electrodes. We investigated the electrochemical performance of Ni–P/Si electrode annealed at various temperatures in this study. The Ni–P/Si electrodes annealed at 800 ± 20 °C exhibited a superior cycle life with a reversible capacity of 1000 mA h g−1 over 1000 cycles, whereas the capacity of the electrodes annealed at temperatures of 750 °C and 850 °C faded at approximately 500 cycles. At 800 °C, a newly formed NiSi2 phase was theorized to significantly contribute to improving adhesion between the Ni–P coating layer and the Si particles. The Ni–P coating particles tended to aggregate at 850 °C, leading to a reduction in the coating effect, that is, a decline in their reactivity with Li+, acceleration of electrode disintegration, and a reduction in electrical conductivity. On the other hand, Ni–P/Si electrodes annealed at 850 °C exhibited a superior rate performance. The amount of available NiSi2 which ultimately contributed to higher reactivity with Li should increase

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

人工股関節全置換術におけるIliopsoas impingementのrisk factorの評価

【受賞研究紹介】令和2年度　日本関節病学会優秀論文

軟骨分化誘導させた脂肪由来幹細胞シートによる変形性膝関節症の軟骨再生

金沢大学医薬保健研究域医学系日本白色家兎の膝OAモデルで、自家末梢血から生成した多血小板血漿(PRP)を用い脂肪由来間葉系幹細胞adipose-derived stem cells (ADSC)の軟骨形成細胞へ分化誘導を評価した。その結果、ADSCの軟骨分化を示唆する遺伝子発現（Collagen Ⅱ, Sox 9 and Aggrecan）を有する軟骨形成細胞への分化を確認した。We evaluated the Induction of differentiation of ADSC into chondrogenic cells using PRP generated from autologous peripheral blood in a knee OA model of a Japanese white rabbit. As a result, chondrogenic cells with gene expression (Collagen II, Sox 9 and aggrecan) was confirmed; that suggested differentiation into chondrogenic cells.研究課題/領域番号:19K18493, 研究期間(年度):2019-04-01 – 2021-03-31出典：「軟骨分化誘導させた脂肪由来幹細胞シートによる変形性膝関節症の軟骨再生」研究成果報告書　課題番号19K18493（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K18493/19K18493seika/）を加工して作