84 research outputs found
Clinical and laboratory predictors for plaque erosion in patients with acute coronary syndromes
Background-—Plaque erosion is responsible for 25% to 40% of patients with acute coronary syndromes (ACS). Recent studies
suggest that anti-thrombotic therapy without stenting may be an option for this subset of patients. Currently, however, an invasive
procedure is required to make a diagnosis of plaque erosion. The aim of this study was to identify clinical or laboratory predictors
of plaque erosion in patients with ACS to enable a diagnosis of erosion without additional invasive procedures.
Methods and Results-—Patients with ACS who underwent optical coherence tomography imaging were selected from 11
institutions in 6 countries. The patients were classified into plaque rupture, plaque erosion, or calcified plaque, and predictors were
identified using multivariable logistic modeling. Among 1241 patients with ACS, 477 (38.4%) patients were found to have plaque
erosion. Plaque erosion was more frequent in non–ST-segment elevation-ACS than in ST-segment–elevation myocardial infarction
(47.9% versus 29.8%, P=0.0002). Multivariable logistic regression models showed 5 independent parameters associated with
plaque erosion: age 15.0 g/dL, and normal renal function. When
all 5 parameters are present in a patient with non–ST-segment elevation-ACS, the probability of plaque erosion increased to 73.1%.
Conclusions-—Clinical and laboratory parameters associatedwith plaque erosion are explored in this retrospective registry study. These
parametersmay be useful to identify the subset ofACS patients with plaque erosion and guide themto conservativemanagement without
invasive procedures. The results of this exploratory analysis need to be confirmed in large scale prospective clinical studiesDr. Jang has received an educational grant from Abbott
Vascular and Medicure. Dr. Adriaenssens has received grants
and consulting fees from Abbott Vascula
A hydroxypropyl methylcellulose plaque assay for human respiratory syncytial virus
ウイルスの研究において感染性のあるウイルス粒子を正確に定量することは,病原性の評価のみならずウイルスに対する新規治療薬の効果を客観的に評価するために極めて重要な手技である.プラークアッセイ法はウイルス粒子を定量するために不可欠な技術であるが,Respiratory syncytial virus(RSV)において,プラークアッセイ法を安定して行うことはしばしば困難である.今回我々は,overlay material(充填化合物)が細胞増殖に与える影響を中心にRSVおよびhuman metapneumovirus(hMPV)におけるプラークアッセイ法の最適化の検討を行った
Of mice and men--universality and breakdown of behavioral organization.
Mental or cognitive brain functions, and the effect on them of abnormal psychiatric diseases, are difficult to approach through molecular biological techniques due to the lack of appropriate assay systems with objective measures. We therefore study laws of behavioral organization, specifically how resting and active periods are interwoven throughout daily life, using objective criteria, and first discover that identical laws hold both for healthy humans subject to the full complexity of daily life, and wild-type mice subject to maximum environmental constraints. We find that active period durations with physical activity counts successively above a predefined threshold, when rescaled with individual means, follow a universal stretched exponential (gamma-type) cumulative distribution, while resting period durations below the threshold obey a universal power-law cumulative distribution with identical parameter values for both of the mammalian species. Further, by analyzing the behavioral organization of mice with a circadian clock gene (Period2) eliminated, and humans suffering from major depressive disorders, we find significantly lower parameter values (power-law scaling exponents) for the resting period durations in both these cases. Such a universality and breakdown of the behavioral organization of mice and humans, revealed through objective measures, is expected to facilitate the understanding of the molecular basis of the pathophysiology of neurobehavioral diseases, including depression, and lay the foundations for formulating a range of neuropsychiatric behavioral disorder models
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