VLBI Astrometry of the Semiregular Variable RX Bootis

We present distance measurement of the semiregular variable RX Bootis (RX Boo) with its annual parallax. Using the unique dual-beam system of the VLBI Exploration of Radio Astrometry (VERA) telescope, we conducted astrometric observations of a water maser spot accompanying RX Boo referred to the quasar J1419+2706 separated by 1.69 degrees from RX Boo. We have measured the annual parallax of RX Boo to be 7.31 +/- 0.50 mas, corresponding to a distance of 136 +10/-9 pc, from the one-year monitoring observation data of one maser spot at VLSR = 3.2 km/s. The distance itself is consistent with the one obtained with Hipparcos. The distance uncertainty is reduced by a factor of two, allowing us to determine the stellar properties more accurately. Using our distance, we discuss the location of RX Boo in various sequences of Period-Luminosity (PL) relations. We found RX Boo is located in the Mira sequence of PL relation. In addition, we calculated the radius of photosphere and the mass limitation of RX Boo and discussed its evolutionary status.Comment: 8 pages, 4figure

Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis-related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study

Background The J-Land 3S trial demonstrated that landiolol is effective and tolerated for treating sepsis-related tachyarrhythmias. Patient characteristics (e.g. baseline heart rate [HR], type of tachyarrhythmia, and concomitant disorders) may impact the outcomes of landiolol therapy. We performed subanalyses of J-Land 3S to evaluate the impact of patient characteristics on the efficacy and safety of landiolol for treating sepsis-related tachyarrhythmia. Methods Patients (≥20 years old; N = 151) hospitalised with sepsis at 54 participating hospitals in Japan with HR ≥100 beats/min for ≥10 min accompanied by diagnosis of tachyarrhythmia were randomised 1:1 to conventional sepsis therapy alone (control group) or conventional sepsis therapy plus landiolol (landiolol group). The efficacy and safety of landiolol were assessed in prespecified analyses of patients divided into subgroups by baseline characteristics and in post hoc, multivariate analyses with adjustment for age and HR at baseline. Findings The percentage of patients with HR of 60–94 beats/min at 24 h after randomisation (primary endpoint) was greater in the landiolol group in most subgroups in univariate unadjusted analyses and in multivariate logistic regression. The incidence of new-onset arrhythmia by 168 h and mortality by 28 days were also lower in the landiolol group in most subgroups in univariate and multivariate Cox proportional hazards models. No subgroups showed a markedly higher incidence of adverse events in univariate or multivariate logistic regression analyses

Deep-Sea Robotic Survey and Data Processing Methods for Regional-Scale Estimation of Manganese Crust Distribution

Manganese crusts (Mn-crusts) are a type of mineral deposit that exists on the surface of seamounts and guyots at depths of >800 m. We have developed a method to efficiently map their distribution using data collected by autonomous underwater vehicles and remotely operated vehicles. Volumetric measurements of Mn-crusts are made using a high-frequency subsurface sonar and a 3-D visual mapping instrument mounted on these vehicles. We developed an algorithm to estimate Mn-crust distribution by combining continuous subsurface thickness measurements with the exposed surface area identified in 3-D maps. This is applied to data collected from three expeditions at Takuyo Daigo seamount at depths of ~1400 m. The transects add to ~11 km in length with 12 510 m 2 mapped. The results show that 52% of the surveyed area is covered by Mn-crusts with a mean thickness of 69.6 mm. The mean Mn-crust occurrence is 69.6 kg/m 2 with a maximum of 204 kg/m 2 in the mapped region. The results are consistent with estimates made from samples retrieved from the area, showing more detailed distribution patterns and having significantly lower uncertainty bounds for regional-scale Mn-crust inventory estimation

バディシステムを用いたスキー実習が女子大学生の社会的スキルに及ぼす影響：問題解決因子およびコミュニケーション因子の変化に着目して

The purpose of this study was to examine the effects of a ski training program, rounded in the “buddy system,” on the social skills of students at a women’s university. A group of twelve students, serving as the intervention group, participated in the ski training program using the buddy system, while another group of twelve students participated in program lacking the buddy system, as a control group. The easurement of social skills was conducted on the first and final days of the ski training program by using the social skills scale（ KiSS-18）. The researchers conducted ２ （group: intervention and control groups） × ２ （time: first and final days of the ski training program） repeated ANOVA tests, using scores from the KiSS-18. The results indicated that the group × time interaction was significant, with relation to “problem solving skills.” The score of intervention group was higher than that of the control group, in terms of problem solving skills, as measured on the final day of the programs. These findings suggested that a ski training program employing the buddy system may lead to enhancement of the social skills of women’s university students

Glucosyl hesperidin exhibits more potent anxiolytic activity than hesperidin accompanied by the attenuation of noradrenaline induction in a zebrafish model

Anxiety is a symptom of various mental disorders, including depression. Severe anxiety can significantly affect the quality of life. Hesperidin (Hes), a flavonoid found in the peel of citrus fruits, reportedly has various functional properties, one of which is its ability to relieve acute and chronic stress. However, Hes is insoluble in water, resulting in a low absorption rate in the body and low bioavailability. Glucosyl hesperidin (GHes) is produced by adding one glucose molecule to hesperidin. Its water solubility is significantly higher than that of Hes, which is expected to improve its absorption into the body and enhance its effects. However, its efficacy in alleviating anxiety has not yet been investigated. Therefore, in this study, the anxiolytic effects of GHes were examined in a zebrafish model of anxiety. Long-term administration of diets supplemented with GHes did not cause any toxicity in the zebrafish. In the novel tank test, zebrafish in the control condition exhibited an anxious behavior called freezing, which was significantly suppressed in GHes-fed zebrafish. In the black-white preference test, which also induces visual stress, GHes-fed zebrafish showed significantly increased swimming time in the white side area. Furthermore, in tactile (low water-level stress) and olfactory-mediated stress (alarm substance administration test) tests, GHes suppressed anxious behavior, and these effects were stronger than those of Hes. Increased noradrenaline levels in the brain generally cause freezing; however, in zebrafish treated with GHes, the amount of noradrenaline after stress was lower than that in the control group. Activation of c-fos/ERK/Th, which is upstream of the noradrenaline synthesis pathway, was also suppressed, while activation of the CREB/BDNF system, which is vital for neuroprotective effects, was significantly increased. These results indicate that GHes has a more potent anxiolytic effect than Hes in vivo, which may have potential applications in drug discovery and functional food development

Kaon-condensed hypernuclei as highly dense self-bound objects

The structure of $K^-$-condensed hypernuclei, which may be produced in the laboratory in strangeness-conserving processes, is investigated using an effective chiral Lagrangian for the kaon-baryon interaction, combined with a nonrelativistic baryon-baryon interaction model. It is shown that a large number of negative strangeness is needed for the formation of highly dense and deeply bound state with kaon condensates and that part of the strangeness should be carried by hyperons mixed in the nucleus. The properties of kaon-condensed hypernuclei such as the ground state energy and particle composition are discussed. Such a self-bound object has a long lifetime and may decay only through weak interaction processes. Comparison with other possible nuclear states is also made, such as kaon-condensed nuclei without mixing of hyperons and noncondensed multistrange hypernuclei. Implications of kaon-condensed hypernuclei for experiments are mentioned.Comment: 30 pages, 10 figure

Visualization for the corrosion reaction of the metal surface

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The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Background and purposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] https://doi.org/10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals