A Study on the Thin Plate with Carbon Fiber Reinforced Hybrid Composite

In this paper we describe an experimental study, this article is to report fundamental data of constructions attained by carbon fiber reinforced hybrid composite of O.9mm in thickness whose resin base was reinforced. As a result of this series of test and experiments, it was found that; it is possible to attain reinforced resin base of hybrid composite of C.F.R.P. 16 times as much in rigidity against bending load as compared with that of single construction was observed with composite of O.9mm lamina. It was found that sandwich construction of C.F.R.P. is superior, while, in the case of canape construction, it was found necessary to have C.F.R.P. on the tension side. G.F.R.P. has possibility to be reinforced composite material, although it is considerably less superior to C.F.R.P

KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration

AbstractAgonists for EP4 receptor, a prostaglandin E2 receptor subtype, appear to be a promising therapeutic strategy for ulcerative colitis (UC) due to their anti-inflammatory and epithelial regeneration activities. However, the clinical development of orally-available EP4 agonists for mild to moderate UC has not yet been reported. Furthermore, the possibility of an increased risk of colitis-associated cancer (CAC) through direct proliferative effects on epithelial cells via EP4 signaling has not been ruled out. Recently, we identified KAG-308 as an orally-available EP4-selective agonist. Here, we investigated the pharmacological and pharmacokinetic profiles of KAG-308. Then, we compared KAG-308 and sulfasalazine (SASP) for their abilities to prevent colitis and promote mucosal healing in a mouse model of dextran sulfate sodium (DSS)-induced colitis. Finally, the effect of KAG-308 treatment on CAC was evaluated in an azoxymethane (AOM)/DSS-induced CAC mouse model. KAG-308 selectively activated EP4 and potently inhibited tumor necrosis factor-α production in peripheral whole blood and T cells. Oral administration of KAG-308, which showed relatively high bioavailability, suppressed the onset of DSS-induced colitis and promoted histological mucosal healing, while SASP did not. KAG-308 also prevented colorectal carcinogenesis by inhibiting colitis development and consequently decreasing mortality in a CAC model, whereas SASP had marginal effects. In contrast, MF-482, an EP4 antagonist, increased mortality. These results indicated that orally-administered KAG-308 suppressed colitis development and promoted mucosal healing. Moreover, it exhibited preventive effects on colorectal carcinogenesis, and thus may be a new therapeutic strategy for the management of UC that confers a reduced risk of colorectal carcinogenesis

Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors

Focused structure-activity relationships of isoindoline class DPP-IV inhibitors have led to the discovery of 4b as a highly selective, potent inhibitor of DPP-IV. In vivo studies in Wistar/ST rats showed that 4b was converted into the strongly active metabolite 4l in high yield, resulting in good in vivo efficacy for antihyperglycemic activity

The collaborative role of oral surgery with plastic as well as head & neck surgery in head and neck cancers : Preoperative plate-bending method in cases with mandibular reconstruction using plaster 3D models

The collaboration of various medical teams is crucial for the appropriate treatment of cancer patients. However, in Japan, it is very difficult for oral surgeons to cooperate with head and neck surgeons due to conflicts in the treatment of those patients. There have been few studies on this subject. In the current work, we report on the collaboration of head and neck surgeons, plastic surgeons and oral surgeons in operations on two patients with gingival carcinomas in the mandible. We first prepared plaster 3D models of the patients'mouths by means of ink-jet from CT data. We pre-bent the reconstruction plates using the preoperative 3D models. Therefore, we could save the time required to bend the plate. Plaster models are cheaper than resin models. It is also easy to model the surgery using the plate. During the operation, head and neck surgeons resected the tumors, plastic surgeons performed reconstruction with vascularized bone or skin graft, and oral surgeons (dentists) did plate fixation and took charge of the patients'occlusion. This method resulted in patients having good occlusion after the operation

A pristine record of outer Solar System materials from asteroid Ryugu’s returned sample

Volatile and organic-rich C-type asteroids may have been one of the main sources of Earth’s water. Our best insight into their chemistry is currently provided by carbonaceous chondritic meteorites, but the meteorite record is biased: only the strongest types survive atmospheric entry and are then modified by interaction with the terrestrial environment. Here we present the results of a detailed bulk and microanalytical study of pristine Ryugu particles, brought to Earth by the Hayabusa2 spacecraft. Ryugu particles display a close compositional match with the chemically unfractionated, but aqueously altered, CI (Ivuna-type) chondrites, which are widely used as a proxy for the bulk Solar System composition. The sample shows an intricate spatial relationship between aliphatic-rich organics and phyllosilicates and indicates maximum temperatures of ~30 °C during aqueous alteration. We find that heavy hydrogen and nitrogen abundances are consistent with an outer Solar System origin. Ryugu particles are the most uncontaminated and unfractionated extraterrestrial materials studied so far, and provide the best available match to the bulk Solar System composition

腎孟篇平上皮癌の1例

We describe a case of a 75-year-old woman with squamous cell carcinoma in the right renal pelvis accompanied by multiple dysplasia in the upper urinary tract. Though it is difficult to make a preoperative diagnosis of squamous cell carcinoma, lavage cytology is particularly valuable. Renal arteriography and cross-sectional imaging are also useful to assess an accurate stage. We postulate that severe dysplasia could be a precursor of squamous cell carcinoma as well as transitional cell carcinoma

動特性を求めるための構造物試験について(概要)

For establishment of antiseismic design, it is one of the most important problems toevaluate dynamical characteristics of structure. The method of determining the dynam-ical characteristics of actual structures by the seismic test is considered as one of effec-tive approach to this problem, but practical procedure of the test and evaluation of theresults must be precisely examined in the application of this method concerning withobject of the test and also with type of the structure.In this paper discussed are the various questions on the test for dynamical character-istics of actual structures in the case of the forced vibration test and the measurement ofmicro-tremors of structure. And then, regarding to the natural periods and critical damp-ing ratios that are considered as basic quantities of the structure in elastic range, themethod of determining these quantities are applied on the five story steel framed structurewith rectangular plan.From the results of the steady-state forced vibration test and of the measurement ofmicro-tremors of the structure, resonance curves, auto-correlation function, and spectraldensity are calculated. With respect to these numerical results, estimation of natural pe-rinds and critical damping ratios is discussed.Some conclusions are pointed out as follows:1) It should be careful for us to evaluate the reasonable value of critical dampingratio from the resonance curve because of the various test conditions.2) The exsct values of lower natural periods can be easily computed from spectraldensity, but some correction for the computation procedure of spectral density shouldbe required to evaluate critical damping ratio from spectral density as to input and out-put.For establishment of antiseismic design, it is one of the most important problems toevaluate dynamical characteristics of structure. The method of determining the dynam-ical characteristics of actual structures by the seismic test is considered as one of effec-tive approach to this problem, but practical procedure of the test and evaluation of theresults must be precisely examined in the application of this method concerning withobject of the test and also with type of the structure.In this paper discussed are the various questions on the test for dynamical character-istics of actual structures in the case of the forced vibration test and the measurement ofmicro-tremors of structure. And then, regarding to the natural periods and critical damp-ing ratios that are considered as basic quantities of the structure in elastic range, themethod of determining these quantities are applied on the five story steel framed structurewith rectangular plan.From the results of the steady-state forced vibration test and of the measurement ofmicro-tremors of the structure, resonance curves, auto-correlation function, and spectraldensity are calculated. With respect to these numerical results, estimation of natural pe-rinds and critical damping ratios is discussed.Some conclusions are pointed out as follows:1) It should be careful for us to evaluate the reasonable value of critical dampingratio from the resonance curve because of the various test conditions.2) The exsct values of lower natural periods can be easily computed from spectraldensity, but some correction for the computation procedure of spectral density shouldbe required to evaluate critical damping ratio from spectral density as to input and out-put