PDMAEMA Hidrojelinin pH ve Sıcaklık Değişimine Karşı Hızlı Büzülme Davranışı ve Kontrollü İlaç Salımında Uygulaması

In this study, poly(2‐dimethylamino)ethyl methacrylate (PDMAEMA)    gels were prepared via in situ polymerization reaction. Synthesized hydrogel was characterized with FTIR spectroscopy and SEM. The pH‐ and temperature dependentswelling / deswelling behavior was investigated. The hydrogelshowed highest value of swelling at pH 2. The rising temperature led to a decrease in swelling ratio due to the fact that hydrophobic interactions between polymer segments become dominant. Furthermore, it was observed that PDMAEMA hydrogel exhibited rapid deswelling rate in response to temperature and pH. The drug release profile of PDMAEMA hydrogel has been reported by using Ibuprofen as a model drug.Bu çalışmada, poli(2‐dimetilaminoetil metakrilat) (PDMAEMA) jeli, in situ polimerizasyon yöntemiyle sentezlenmiştir. Sentezlenen hidrojel, FTIR spektroskopisi ve taramalı elektron mikroskobu (SEM) ile karakterize edilmiştir. PDMAEMA jelinin, pH ve sıcaklığa bağlı şişme / büzülme davranışı incelenmiştir. Hidrojel pH 2’de en yüksek denge şişme oranına ulaşmıştır. Artan sıcaklık, polimerik zincirler arasında hidrofobik etkileşimlerin baskın hale gelmesi nedeniyle hidrojelin şişme oranında azalmaya yol açmıştır. Bundan başka hidrojelin sıcaklık ve pH duyarlı büzülme cevap hızının oldukça yüksek olduğu gözlenmiştir.  İbuprofen ilacı model olarak kullanılarak PDMAEMA jelinin ilaç salım profili rapor edilmiştir

PDMAEMA Hidrojelinin pH ve Sıcaklık Değişimine Karşı Hızlı Büzülme Davranışı ve Kontrollü İlaç Salımında Uygulaması

Bu çalışmada, poli(2-dimetilaminoetil metakrilat) (PDMAEMA) jeli, in situ polimerizasyon yöntemiyle sentezlenmiştir. Sentezlenen hidrojel, FTIR spektroskopisi ve taramalı elektron mikroskobu (SEM) ile karakterize edilmiştir. PDMAEMA jelinin, pH ve sıcaklığa bağlı şişme / büzülme davranışı incelenmiştir. Hidrojel pH 2'de en yüksek denge şişme oranına ulaşmıştır. Artan sıcaklık, polimerik zincirler arasında hidrofobik etkileşimlerin baskın hale gelmesi nedeniyle hidrojelin şişme oranında azalmaya yol açmıştır. Bundan başka hidrojelin sıcaklık ve pH duyarlı büzülme cevap hızının oldukça yüksek olduğu gözlenmiştir.  İbuprofen ilacı model olarak kullanılarak PDMAEMA jelinin ilaç salım profili rapor edilmiştir.In this study, poly(2-dimethylamino)ethyl methacrylate (PDMAEMA)    gels were prepared via in situ polymerization reaction. Synthesized hydrogel was characterized with FTIR spectroscopy and SEM. The pH- and temperature dependentswelling / deswelling behavior was investigated. The hydrogelshowed highest value of swelling at pH 2. The rising temperature led to a decrease in swelling ratio due to the fact that hydrophobic interactions between polymer segments become dominant. Furthermore, it was observed that PDMAEMA hydrogel exhibited rapid deswelling rate in response to temperature and pH. The drug release profile of PDMAEMA hydrogel has been reported by using Ibuprofen as a model drug

Novel zwitterionic ABA-type triblock copolymer for pH- and salt-controlled release of risperidone

WOS: 000365959300005An ABA-type triblock copolymer was synthesized through group-transfer polymerization by using poly[2(diethylamino) ethyl methacrylate] (PDEA) as A block and poly[2-(dimethylamino) ethyl methacrylate] (PDMA) as B block. By utilizing the 1,3-propane sultone to obtain polyzwitterionic triblock copolymer under moderate conditions, PDMA block of the triblock copolymer has been selectively betainized. The selectively betainized block copolymer and its precursor were molecularly dissolved in acidic aqueous media without any use of cosolvent at room temperature. In both cases, an increase in solution pH caused near monodisperse cationic or neutral flower-like micellization with hydrophobic PDEA-core at basic aqueous solution. However, at higher polymer concentrations where precursor triblock copolymer does not exhibit any gelling behavior (10% and higher), polyzwitterionic copolymer derivative can be gelated as a result of inter-chain integration of polyzwitterionic groups. Furthermore, the load of risperidone (RISP) into gel matrix and release studies have been successively realized. The results indicated that the betainized novel gel is appropriate for using as a pH- and salt-controlled risperidone-releasing system

Preparation and characterization of novel silk fibroin/2-(N,N-dimethylamino)ethyl methacrylate based composite hydrogels with enhanced mechanical properties for controlled release of cefixime

Hydrogels with improved mechanical properties have been particularly attractive for their applications in the biomedical area including wound healing. For this purpose, a series of novel composite hydrogels based on silk fibroin (SF) and 2-(N,N-dimethylamino) ethyl methacrylate (DMAEMA) were fabricated. The swelling and mechanical tests indicated that an optimum design of hydrogel was essential to provide a high degree of water uptake, higher tensile strength and elongation at break values. Here, the S40D60 was exhibited superior swelling and strong mechanical characteristics than all the other hydrogels with different compositions. Furthermore, it was observed that the cefixime was released from the formulation of S40D60 in a sustainable manner and the drug release rate can be controlled by pH of the dissolution medium. According to these findings, it is suggested that the optimal formulation of S40D60 would be effectively performed in situ drug therapy for wound healing. © 2017 Taylor & Francis Group, LLC

Novel Polymer-Bentonite Sorbent for Recovery of Antioxidant Polyphenols from Cornus mas L. through Integrated Process Extraction/Adsorption: Optimization of Extraction Parameters by Response Surface Methodology

Here, ultrasound-assisted extraction with ultrasonic probe of total polyphenolic content from leaves of cornelian cherry (Cornus mas L.) was studied. Batch adsorption was carried out to concentrate polyphenol extract using bentonite/2-(dimethyl amino) ethyl methacrylate composite adsorbent. The extraction was optimized through face central composite design combined with response surface methodology. It was found that bentonite/2-(dimethyl amino) ethyl methacrylate composite exhibits significant adsorption capacity (2407.50 mg-GAE/g-bentonite/2-(dimethyl amino) ethyl methacrylate composite) for polyphenols in cornelian cherry leaves. It was observed that pH was the crucial factor and highest adsorption capacity was obtained at pH 10. © 2016, Copyright © Taylor & Francis Group, LLC

Novel zwitterionic ABA-type triblock copolymer for pH-and salt-controlled release of risperidone

An ABA-type triblock copolymer was synthesized through group-transfer polymerization by using poly[2-(diethylamino) ethyl methacrylate] (PDEA) as A block and poly[2-(dimethylamino) ethyl methacrylate] (PDMA) as B block. By utilizing the 1,3-propane sultone to obtain polyzwitterionic triblock copolymer under moderate conditions, PDMA block of the triblock copolymer has been selectively betainized. The selectively betainized block copolymer and its precursor were molecularly dissolved in acidic aqueous media without any use of cosolvent at room temperature. In both cases, an increase in solution pH caused near monodisperse cationic or neutral flower-like micellization with hydrophobic PDEA-core at basic aqueous solution. However, at higher polymer concentrations where precursor triblock copolymer does not exhibit any gelling behavior (10% and higher), polyzwitterionic copolymer derivative can be gelated as a result of inter-chain integration of polyzwitterionic groups. Furthermore, the load of risperidone (RISP) into gel matrix and release studies have been successively realized. The results indicated that the betainized novel gel is appropriate for using as a pH-and salt-controlled risperidone-releasing system. © 2016 Taylor and Francis Group, LLC

Synthesis of novel poly[2-(dimethylamino) ethyl methacrylate]/Pumice stone hydrogel composite for the rapid adsorption of humic acid in aqueous solution

In this study, a novel hydrogel composite, poly[2-(dimethylamino) ethyl methacrylate]/pumice (PDMAEMA/Pmc) was designed and its sorption behavior for humic acid (HA) was produced by using batch adsorption techniques. FTIR results showed that pumice was well incorporated with the PDMAEMA matrix. A scanning electron microscopy (SEM) was used in order to determine the morphology of composite hydrogel. In the batch experiments, the adsorption capacity was evaluated depending on different variables such as ionic strength; initial HA concentration; pH and adsorbent dosage. The adsorption capacity was found to be 86.27 mg/g under the optimized conditions. The results revealed that HA adsorption onto PDMAEMA/Pmc was well expressed by the Freundlich isotherm model and the adsorption process was followed by the pseudo second order kinetic model. The reusability tests also indicated that novel PDMAEMA/Pmc adsorbent was an efficient and cost-effective adsorbent for removal of HA. © 2015 Taylor and Francis Group, LLC

Rapid Deswelling of Porous Poly[2-(N-morpholino)ethyl methacrylate] Hydrogel and Controlled Release of Ibuprofen

A novel, rapidly responsive, cross-linkedpoly[(2-N morpholino)ethyl methacrylate] (PMEMA) hydrogel was synthesized through free radical polymerization at room temperature. The highly swellable PMEMA gel displayed rapid deswelling kinetics in response to salt and temperature changes in its environment. During the deswelling test the hydrogel lost 75% of its water within 4 min in response to the salt effect, while it lost only 30% of its water in response to a temperature change within the same interval. Scanning electron microscopy revealed that the PMEMA gel has numerous open pore channels allowing rapid diffusion of water or water-soluble molecules from the gel matrix. Such a rapid response to environmental stimuli is promising for biomedical applications. Therefore, the designed gel was used as a potential drug carrier using water insoluble Ibuprofen (IBU) as a test drug. The results suggest that the PMEMA hydrogel would be beneficial for achieving a slow/controlled release of water-insoluble drugs. © 2017 Taylor & Francis Group, LLC

Novel Polymer-Bentonite Sorbent for Recovery of Antioxidant Polyphenols from Cornus mas L. through Integrated Process Extraction/Adsorption: Optimization of Extraction Parameters by Response Surface Methodology

Here, ultrasound-assisted extraction with ultrasonic probe of total polyphenolic content from leaves of cornelian cherry (Cornus mas L.) was studied. Batch adsorption was carried out to concentrate polyphenol extract using bentonite/2-(dimethyl amino) ethyl methacrylate composite adsorbent. The extraction was optimized through face central composite design combined with response surface methodology. It was found that bentonite/2-(dimethyl amino) ethyl methacrylate composite exhibits significant adsorption capacity (2407.50 mg-GAE/g-bentonite/2-(dimethyl amino) ethyl methacrylate composite) for polyphenols in cornelian cherry leaves. It was observed that pH was the crucial factor and highest adsorption capacity was obtained at pH 10