51 research outputs found
The impact of mid-wall striate of LGE at interventricular septum to the beta-broker (Carvedilol) titrating to the target dose and the improvement of cardiac function with DCM
Effects of safflower seed extract on arterial stiffness
Safflower seed extract (SSE) contains characteristic polyphenols and serotonin derivatives (N-( p-coumaroyl) serotonin and N-feruloylserotonin), which are reported to inhibit oxidation of low-density lipoprotein (LDL), formation of atherosclerotic plaques, and improve arterial stiffness as assessed by pulse wave analysis in animal models. The effects of long-term supplementation with SSE on arterial stiffness in human subjects were evaluated. This doubleblind, placebo-controlled study was conducted in 77 males (35โ65 years) and 15 postmenopausal females (55โ65 years) with high-normal blood pressure or mild hypertension who were not undergoing treatment. Subjects received SSE (70 mg/day as serotonin derivatives) or placebo for 12 weeks, and pulse wave measurements, ie, second derivative of photoplethysmogram (SDPTG), augmentation index, and brachial-ankle pulse wave velocity (baPWV) were conducted at baseline, and at weeks 4, 8, and 12. Vascular age estimated by SDPTG aging index improved in the SSE-supplemented group when compared with the placebo group at four (P = 0.0368) and 12 weeks (P = 0.0927). The trend of augmentation index reduction (P = 0.072 versus baseline) was observed in the SSE-supplemented group, but reduction of baPWV by SSE supplementation was not observed. The SSE-supplemented group also showed a trend towards a lower malondialdehyde-modified-LDL autoantibody titer at 12 weeks from baseline. These results suggest long-term ingestion of SSE in humans could help to improve arterial stiffness
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Hand posture affects brain-function measures associated with listening to speech.
A major difficulty in studies of the brain, from the molecular to large-scale network level, is ensuring the accuracy and reliability of results, since repeatability has been a problem in studies utilizing functional magnetic resonance imaging (f-MRI) near-infrared spectroscopy (NIRS), and positron-emission tomography (PET). More generally, an effort to replicate psychological studies has shown that the original results were unambiguously reobtained only 39% of the time. It has been suggested that researchers must undertake studies to identify factors that reduce reliability and conduct more carefully controlled studies to improve reliability. In our previous work, we examined whether changes in hand/arm posture can have a confounding effect on task-related brain activity. Here we show a solution to enhance reproducibility in a NIRS study in a hearing task. The results showed that crossed posture can lead to different results than parallel posture with respect to asymmetric functional connectivity, especially during non-resting state. Even when the only task is listening to speech stimuli, participants should be asked to place their hands on a surface and feet on the floor and keep the same stable posture to increase reproducibility of results. To achieve accurate reliability and reproductively of results, stable hand posture through the experiment is important
Recommended from our members
Hand posture affects brain-function measures associated with listening to speech.
A major difficulty in studies of the brain, from the molecular to large-scale network level, is ensuring the accuracy and reliability of results, since repeatability has been a problem in studies utilizing functional magnetic resonance imaging (f-MRI) near-infrared spectroscopy (NIRS), and positron-emission tomography (PET). More generally, an effort to replicate psychological studies has shown that the original results were unambiguously reobtained only 39% of the time. It has been suggested that researchers must undertake studies to identify factors that reduce reliability and conduct more carefully controlled studies to improve reliability. In our previous work, we examined whether changes in hand/arm posture can have a confounding effect on task-related brain activity. Here we show a solution to enhance reproducibility in a NIRS study in a hearing task. The results showed that crossed posture can lead to different results than parallel posture with respect to asymmetric functional connectivity, especially during non-resting state. Even when the only task is listening to speech stimuli, participants should be asked to place their hands on a surface and feet on the floor and keep the same stable posture to increase reproducibility of results. To achieve accurate reliability and reproductively of results, stable hand posture through the experiment is important
No Significant Differences Were Observed in the Amounts of DNA Strand Breaks Produced by Copper between Male and Female Liver Cells of Long-Evans Cinnamon๏ผLEC) Strain Rats
่็ใ่ช็ถ็บ็ใใLECใฉใใใฎ่็ดฐ่ใซ่็ฉใใ้
ใซใใ้
ธๅๆๅทใจ่ใใใใDNAๅ้ๅๆญใฎ้ใใณใกใใๆณใงๆคๅบใใใLECใฉใใใฎ่่ใงใฏ4้ฑ้ฝขใงใณใณใใญใผใซใจใใฆ็จใใWKAHใฎ30ๅใฎ้
ใ่็ฉใใฆใใใ4้ฑ้ฝขใใ15้ฑ้ฝขใงใฏ้ใ้ใจใใซ้ฑ้ฝขใซไพๅญใใฆ่่ใฎ้
ใฎ่็ฉ้ใฏๅขๅ ใใใใWKAHใฉใใใงใฏ้ฑ้ฝขใซใใๅขๅ ใฏ่ชใใใใชใใฃใใLECใฉใใใฎ่่ใงใฎDNAๅ้ๅๆญใฎ้ใฏ10้ฑ้ฝขใใ15้ฑ้ฝขใพใง้ฑ้ฝขใซไพๅญใใฆๆฅๆฟใซๅขๅ ใใใ่็็บ็ใฏ้ใ้ใซๆฏในใฆ้ ปๅบฆใ้ซใใใจใๅ ฑๅใใใฆใใใใ่็ดฐ่ใซใใใ้ใฎDNAๅ้ๅๆญใฎ้ใฏ้ใซๆฏในใฆๅคงใใช้ใใฏ่ชใใใใชใใฃใ
Hepatic iron Accumulation Is Not Directly Associated with Induction of DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon๏ผLEC) Rats
่็ใ่ช็ถ็บ็ใใLECใฉใใใซใใใฆDNAๅ้ๅๆญใซๅใผใ้
ใฎ่็ฉใฎๅฝฑ้ฟใ่ชฟในใใLECใฉใใใฎ่่ใซใใใฆ้
ใจ้ใฏ4้ฑ้ฝขใใ15้ฑ้ฝขใซ่็ฉใใใไฝ้้ฃใง้ฃผ่ฒใใใฉใใใงใฏ้ใฎ่็ฉใฏ่ชใใใใชใใฃใใใ้
ใฎ่็ฉใฏๆฎ้้ฃใฎใฉใใใจๅๆง้่ชใใใใใ่็ดฐ่ใฎDNAๅ้ๅๆญใฎ้ใฏcometๆณใ็จใใฆๆคๅบใใใใใผใซใ่ชใใใใ็ดฐ่ใฎ้ ปๅบฆใจใใผใซใฎ้ทใใฎๅนณๅๅคใๆฑใใใจใใใไฝ้้ฃใไธใใLECใฉใใใฎ่็ดฐ่ใจๆฎ้้ฃใไธใใLECใฉใใใฎ้ใซใปใจใใฉ้ใใฏ่ชใใใใชใใฃใใใใใใฎ็ตๆใใLECใฉใใใฎ่็ดฐ่ใซใใใDNAๆๅทใฎ่ช็บใซใฏ้ใฎ่็ฉใฏ้ขไธใใฆใใชใใใจใ็คบๅใใใ
P112 Influence of Cuff Blood Pressure Accuracy on Identification of Isolated Systolic Hypertension
Abstract
Introduction
Isolated systolic hypertension (ISH) is the most common form of hypertension in older people. However, accurate identification of ISH may be hindered because cuff blood pressure (BP) underestimates systolic BP (SBP) and overestimates diastolic BP (DBP). This study aimed to determine the influence of cuff BP accuracy on the identification of ISH.
Methods
Cuff BP and invasive aortic BP were measured simultaneous (or near-simultaneously) in 1737 subjects (63 ยฑ 12 years, 68% male) during coronary angiography. Data was derived from 32 studies, using 20 different cuff BP devices, from the Invasive Blood Pressure Consortium (INSPECT). ISH was defined as โฅ140/<90 mmHg according to cuff BP and invasive aortic BP.
Results
According to cuff BP, 25% of subjects (n = 430) had ISH, however, 37% (n = 648) were identified with ISH from invasive aortic BP. There was 77% concordance between cuff and invasive BP for identifying ISH. Among the 23% (n = 408) of subjects misclassified by cuff BP, 38% (n = 155) of misclassification was from SBP underestimation (mean: โ16.6, 95% CI: โ18.9 to โ13.9 mmHg), whereas 35% (n = 143) was from DBP overestimation (15.6, 11.9 to 19.0 mmHg) and 20% (n = 83) from SBP overestimation (17.6, 14.4 to 20.5 mmHg). Subjects misclassified were on average 2.7 years older and had greater body mass index (0.8 kg/m2) than those correctly classified.
Conclusion
Approximately one quarter of older subjects have ISH misclassified, mostly because of underestimation of cuff SBP and overestimation of cuff DBP. This demonstrates a need to improve the accuracy of cuff BP methods for greater precision in identifying ISH
Dependence of reaction kinetics and physical and mechanical properties on the reaction systems of acetylation II: physical and mechanical properties
Scientific validation of the training for language-impaired patients using cognitive neuropsychological approach in view of the mechanism of impaired language domain-The temporal lobe involvement in specific language impairment and syntax processing-
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