Aldosterone to Potassium Ratio after Adrenocorticotropin Stimulation in Unilateral Primary Aldosteronism Diagnosis

Article信州医学雑誌 68(3): 159-168(2020)journal articl

Preliminary Study of Uncertainty-Driven Plasma Diffusion II

We have constructed a semiclassical collisional diffusion model. In this model, a field particle is treated as either a point charge or a spatially distributed charge. The test particle is treated as a distributed point charge with Gaussian distribution. It was shown that the collisional changes in velocity in our model is of the same order as the classical theory for a typical proton in a fusion plasma of T = 10 keV and n = 1020 m−3. It was also shown that the spatial extent of the distribution, or the quantum-mechanical uncertainty in position, for the test particle obtained in our model grows in time, and becomes of the order of the average interparticle separation Δ ≡ n−1/3 during a time interval τr ∼×107Δ /gth, where gth = √ 2T/m is the thermal speed, with m being the mass of the particle under consideration. The time interval is 3-4 order of magnitudes smaller than the collision time. This suggests that particle transport cannot be understood in the framework of classical mechanics, and that the quantum-mechanical distribution of individual particles in plasmas may cause the anomalous diffusio

Quantum Mechanical Plasma Scattering

We have solved the two-dimensional time-dependent Schödinger equation for a particle with and without the interparticle potential in a fusion plasma. It was shown that spatial extent of a free particle grows monotonically in time. Such expansion leads to a spatial extent or size of a proton of the order of the average interparticle separation Δl ≡ n−1/3 ∼ 2 × 10−7 m in a time interval of 106 × Δl/vth ∼ 10−7 sec for a plasma with a density n ∼ 1020 m−3 and a temperature T = mvth2/2 ∼ 10 keV. It was also shown that, under a Coulomb potential, the wavefunction of a charged particle first shrink and expand in time. In the expansion phase, at times t ≥ 10−10 sec, the size of particle in the presence of a Coulomb potential is much larger than that in the absence of it

The Relative Dose Intensity Changes during Cycles of Standard Regimens in Patients with Diffuse Large B-Cell Lymphoma

No studies have focused on the trajectory of the average relative dose intensity (ARDI) during cycles of first-line chemotherapy for patients with diffuse large B-cell lymphoma. To evaluate the impact of attenuating ARDI during cycles on overall survival, we conducted a multi-centre, longitudinal, observational retrospective study. A total of 307 analysable patients were enrolled. Multivariate Cox hazards modelling with restricted cubic spline models revealed prognostic benefits of higher ARDI up to, but not after, cycle 6. According to group-based trajectory modelling, patients were classified into five groups depending on the pattern of ARDI changes. Among these, two groups in which ARDI had fallen significantly to less than 50% by cycles 4–6 displayed significantly poorer prognosis, despite increased ARDI in the second half of the treatment period (log-rank p = 0.02). The Geriatric Nutritional Risk Index offered significant prediction of unfavourable ARDI changes (odds ratio 2.540, 95% confidence interval 1.020–6.310; p = 0.044). Up to cycle 6, maintenance of ARDI in all cycles (but particularly in the early cycles) is important for prognosis. Malnutrition is a significant factor that lets patients trace patterns of ARDI changes during cycles of chemotherapy associated with untoward prognosis