Anomalous momentum dependence of the multiband electronic structure of FeSe_1-xTe_x superconductors induced by atomic disorder

When periodicity of crystal is disturbed by atomic disorder, its electronic state becomes inhomogeneous and band dispersion is obscured. In case of Fe-based superconductors, disorder of chalcogen/pnictogen height causes disorder of Fe 3d level splitting. Here, we report an angle-resolved photoemission spectroscopy study on FeSe_1-xTe_x with the chalcogen height disorder, showing that the disorder affects the Fe 3d band dispersions in an orbital-selective way instead of simple obscuring effect. The reverse of the Fe 3d level splitting due to the chalcogen height difference causes the splitting of the hole band with Fe 3d x^2-y^2 character around the Gamma point.Comment: 5 pages, 4 figure

Biogenesis and function of N4-acetylcytidine in tRNA responsible for accurate AUG decoding

学位の種別: 課程博士審査委員会委員 : (主査)東京大学教授 鈴木 勉, 東京大学教授 山東 信介, 東京大学教授 菅 裕明, 東京大学准教授 渡邊 洋一, 東京大学講師 池内 与志穂University of Tokyo(東京大学

Optimization temperature sensitivity using the optically detected magnetic resonance spectrum of a nitrogen-vacancy center ensemble

Temperature sensing with nitrogen vacancy (NV) centers using quantum techniques is very promising and further development is expected. Recently, the optically detected magnetic resonance (ODMR) spectrum of a high-density ensemble of the NV centers was reproduced with noise parameters [inhomogeneous magnetic field, inhomogeneous strain (electric field) distribution, and homogeneous broadening] of the NV center ensemble. In this study, we use ODMR to estimate the noise parameters of the NV centers in several diamonds. These parameters strongly depend on the spin concentration. This knowledge is then applied to theoretically predict the temperature sensitivity. Using the diffraction-limited volume of 0.1 micron^3, which is the typical limit in confocal microscopy, the optimal sensitivity is estimated to be around 0.76 mK/Hz^(1/2) with an NV center concentration of 5.0e10^17/cm^3. This sensitivity is much higher than previously reported sensitivities, demonstrating the excellent potential of temperature sensing with NV centers.Comment: 17 pages, 4 figures, 1 tabl

Postoperative Coagulation Changes in Patients with esophageal carcinoma

Postoperative coagulation changes were studied in 50 patients with esophageal carcinomas for 7 days following operation. Of these, 12 patients were examined further for changes in platelet aggregation rate as an index of platelet function. Just after operation, both platelet count and aggregation rate decreased, but at day 2 when the platelet count reached its lowest point, platelet aggregation returned to the preoperative level. Altough platelet aggregation decreased again, it recovered to the preoperative level earlier than did the platelet count. Changes in prothrombin time, activated partial thromboplastin time and fibrinogen and FDP-E levels may suggest pre-DIC state

Development of molecular distribution analysis method of color pigments on Japanese woodblock prints by Raman spectral-imaging

錦絵をはじめとする多色摺木版画において，色材は木版画を特徴付ける重要な要素である．そのため，色材の分子構造および分子分布の詳細な解析が実現されれば，江戸時代の錦絵制作過程の重要な一部を推察することができる可能性がある．そこで本研究では，分子構造を強く反映した情報が得られるラマン散乱分光法に着目し，色材の分子構造と空間分布を同時に解析が可能な非侵襲的色材解析法の開発を行った．その結果，ラマン散乱分光法を用いることで色材の分子構造解析およびその空間分布を可視化することに成功した．特に，紙面内イメージングから紙の繊維上の色材分布を可視化することに成功した．また，紙面と垂直方向のイメージングから，色材の立体的空間分布を可視化することに成功した．さらに，膠含有/不含色材の空間分布の違いも明らかにし，色材分布に基づく摺刷技術解析の可能性を示した．以上の結果から，本手法は多色摺木版画制作技法の新たな解析手法となると考えられる．Ukiyo-e prints, Japanese multicolor woodblock prints, is a traditional Japanese art that has been flourished since Edo period. To surmise the production technologies of woodblock prints, such as materials, carving technologies, and printing technologies, detailed analysis of color pigments that are one of the most important essential materials used in woodblock prints is required. In this study, we proposed a noninvasive analytical method of color pigments by means of Raman spectral-imaging. Pigment species and its molecular structures were clarified via Raman spectra of pigments. Raman imaging of woodblock prints revealed pigment distribution in plane and cross-section, which provided adhesion states of pigments on paper fibers. We also visualized a different pigment distribution on paper depending on glue content in pigment mixture. Our results indicated that Raman spectral-imaging would be a promising technique for evaluating a production technologies of ancient ukiyo-e prints that was still unknown at present

Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules

Background: Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health burdens closely related to metabolic syndrome. A link between CKD and NASH has been assumed; however, the underlying mechanism is still unknown. Ectopic lipid deposition (ELD) in the hepatocyte results in endoplasmic reticulum (ER) stress, which plays an important role in the development of steatohepatitis. ELD is also assumed to play a role in the development of kidney injury. We aimed to investigate the role of ELD and ER stress in the development of CKD, and evaluate the efficacy of a sodium glucose cotransporter-2 inhibitor, ipragliflozin. Methods: Male FLS-ob/ob mice that closely imitate the pathophysiology of NASH were treated with vehicle or ipragliflozin. Metabolic characteristics, histology of the kidney, ER stress, and apoptotic signals were evaluated. Results: The serum triglyceride was significantly lower in mice treated with ipragliflozin. Ipragliflozin reduced ELD in renal tubules. Ipragliflozin also reduced the expression levels of GRP78 and CHOP, apoptotic cells, and interstitial fibrosis. Conclusions: ELD induced kidney injury through ER stress. Ipragliflozin improved the pathogenesis of CKD by reducing ELD and ER stress in NASH-model mice. Our results suggest ipragliflozin has therapeutic effect on CKD in NASH

Propuesta de mejora del nivel motivacional basado en la teoría de Herzberg para los colaboradores del restaurante de comida China Wok, Chiclayo

En la presente investigación se desarrollo una propuesta de mejora del nivel de motivacional para los colaboradores del restaurante de comida rápida China Wok ubicada en la ciudad de Chiclayo, para lograr el mismo se diagnosticó el nivel de motivación de los trabajadores de la mencionada empresa, por lo que se decidió utilizar como instrumento de medición un cuestionario (encuesta), que fue desarrollada por el autor, y sustentada en la teoría motivacional generada por Frederick Herzberg, en base a los factores motivacionales e higiénicos. La conclusión principal a la que se arribó en la presente tesis, fue que el nivel de motivacional para los colaboradores de China Wok ubicada en la ciudad de Chiclayo, se ubica en un nivel medio alto. En este sentido, los factores motivacionales e higiénicos se ubica en similar nivel. En base a los resultados recopilados para cada dimensión, se desarrolló una propuesta de mejora cuyo objetivo fue optimizar los indicadores que se encuentran en un nivel medio, bajo y muy bajo.Tesi

A novel method for assessing the renal biopsy specimens using an activatable fluorescent probe

Gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is an activatable fluorescent probe that can be activated by γ-glutamyltranspeptidase (GGT). The expression of GGT in the kidney, which is one of the major organs exhibiting enhanced GGT expression, is exclusively localised to the cortex. Here, we aimed to investigate the feasibility of gGlu-HMRG as a probe for the on-site assessment of renal biopsy specimens. gGlu-HMRG fluorescent probe was applied to the renal proximal tubular epithelial cells and cortical collecting duct cells in vitro, mouse kidneys ex vivo, and human biopsy specimens. In addition, the fluorescence intensities in the cortex and the medulla were comparatively evaluated in the biopsy specimens. The fluorescence signal was rapidly detected in the renal proximal tubular epithelial cells, whereas that in the cortical collecting duct cells was not detected. The fluorescence signal was detected in the mouse kidneys ex vivo without markedly affecting the tissue morphology. In the human biopsy specimens, the fluorescence signal in the cortex was significantly distinct from that in the medulla (p?<?0.05). Thus, this fluorescent probe can be used to distinctly identify the renal cortex in the biopsy specimens

Exploiting the potential of meroterpenoid cyclases to expand the chemical space of fungal meroterpenoids

Fungal meroterpenoids are a diverse group of hybrid natural products with impressive structural complexity and high potential as drug candidates. In this work, we evaluate the promiscuity of the early structure diversity-generating step in fungal meroterpenoid biosynthetic pathways: the multibond-forming polyene cyclizations catalyzed by the yet poorly understood family of fungal meroterpenoid cyclases. In total, 12 unnatural meroterpenoids were accessed chemoenzymatically using synthetic substrates. Their complex structures were determined by 2D NMR studies as well as crystalline-sponge-based X-ray diffraction analyses. The results obtained revealed a high degree of enzyme promiscuity and experimental results, together with quantum chemical calculations provided a deeper insight into the catalytic activity of this new family of non-canonical terpene cyclases. The knowledge obtained paves the way to design and engineer artificial pathways towards second generation meroterpenoids with valuable bioactivities based on combinatorial biosynthetic strategies.Accepted manuscrip