FARMACOS ANTIDEPRESSIVOS USADOS NO TRATAMENTO DA DEPRESSÃO EM ESTUDANTES DE MEDICINA E SEU IMPACTO EM SUA VIDA ACADÊMICA.

ABSTRACT OBJECTIVE: To characterize a profile related to the use of medication in depressive disorders in medical students and how to interfere in academic life. METHOD: This is a descriptive quantitative study whose data were obtained through field research using the Google Form, authorized and carried out within the Centro Universitário Fundação Assis Gurgacz. The academics included in the research are those who presente or have been diagnosed with Depression at some point in their lives, and what is the interference in their daily lives. RESULT: The academics said that depression presentes triggers that prevent better results in academic life, such as discouragement or sudden tiredness. Furthmore, the majority of those surveyed live alone and have differential diagnoses associated with depression.OBJETIVO: Caracterizar um perfil relacionado ao uso de fármacos no transtorno depressivo em acadêmicos de medicina e como interfere na vida acadêmica. MÉTODO: Trata-se de um estudo quantitativo descritivo cujos dados foram obtidos através de pesquisa de campo por meio do Formulário do Google, autorizado e realizado dentro do Centro Universitário Fundação Assis Gurgacz. Os acadêmicos enquadrados na pesquisa são aqueles que apresentam ou apresentaram diagnóstico de Depressão em algum momento da vida, e qual a interferencia no dia a dia. RESULTADO: Os acadêmicos relataram que, a depressão apresenta gatilhos que os impedem de melhor proveito da vida acadêmica, como o desânimo ou cansaço repentino. Além de que, a maioria dos pesquisados, moram sozinhos e apresentam diagnósticos diferenciais associados a depressão

Practice patterns and clinical outcomes in acute appendicitis differ in the elderly patient

Background: Appendicitis is the most frequent global abdominal surgical emergency. An ageing population, who often exhibit atypical symptoms and delayed presentations, challenge conventional diagnostic and treatment paradigms. Objectives: This study aims to delineate disparities in presentation, management, and outcomes between elderly patients and younger adults suffering from acute appendicitis. Methods: This subgroup analysis forms part of ESTES SnapAppy, a time-bound multi-center prospective, observational cohort study. It includes patients aged 15 years and above who underwent laparoscopic appendectomy during a defined 90-day observational period across multiple centers. Statistical comparisons were performed using appropriate tests with significance set at p < 0.05. Results: The study cohort comprised 521 elderly patients (≥65 years) and 4,092 younger adults (18–64 years). Elderly patients presented later (mean duration of symptoms: 7.88 vs. 3.56 days; p < 0.001) and frequently required computed tomography (CT) scans for diagnosis (86.1% vs. 54.0%; p < 0.001). The incidence of complicated appendicitis was higher in the elderly (46.7% vs. 20.7%; p < 0.001). Delays in surgical intervention were notable in the elderly (85.0% operated within 24 h vs. 88.7%; p = 0.018), with longer operative times (71.1 vs. 60.3 min; p < 0.001). Postoperative complications were significantly higher in the elderly (27.9% vs. 12.9%; p < 0.001), including severe complications (6.9% vs. 2.4%; p < 0.001) and prolonged hospital stays (7.9 vs. 3.6 days; p < 0.001). Conclusions: Our findings highlight significant differences in the clinical course and outcomes of acute appendicitis in the elderly compared to younger patients, suggesting a need for age-adapted diagnostic pathways and treatment strategies to improve outcomes in this vulnerable population

Perspective—On the Safety of Aged Lithium-Ion Batteries

Concerns about the safety of lithium-ion batteries have motivated numerous studies on the response of fresh cells to abusive, off-nominal conditions, but studies on aged cells are relatively rare. This perspective considers all open literature on the thermal, electrical, and mechanical abuse response of aged lithium-ion cells and modules to identify critical changes in their behavior relative to fresh cells. We outline data gaps in aged cell safety, including electrical and mechanical testing, and module-level experiments. Understanding how the abuse response of aged cells differs from fresh cells will enable the design of more effective energy storage failure mitigation systems.</jats:p

Perspective - On the Safety of Aged Lithium-Ion Batteries

Concerns about the safety of lithium-ion batteries have motivated numerous studies on the response of fresh cells to abusive, off-nominal conditions, but studies on aged cells are relatively rare. This perspective considers all open literature on the thermal, electrical, and mechanical abuse response of aged lithium-ion cells and modules to identify critical changes in their behavior relative to fresh cells. We outline data gaps in aged cell safety, including electrical and mechanical testing, and module-level experiments. Understanding how the abuse response of aged cells differs from fresh cells will enable the design of more effective energy storage failure mitigation systems.</p

Lost But Not Forgotten: Mhc Genotypes Predict Overwinter Survival Despite Depauperate Mhc Diversity In A Declining Frog

The amphibian disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has contributed to the decline of Chiricahua leopard frogs (Rana chiricahuensis), a federally threatened species native to the Southwestern United States. We characterized immunogenetic variability in R. chiricahuensis by sequencing an expressed Major Histocompatibility Complex (MHC) class IIβ gene across 13 natural populations in Arizona, USA, as well as 283 individuals that were captive reared from two egg masses. We recovered a total of five class IIβ MHC alleles compared to 84 alleles previously characterized in eight natural populations of the Arizona congener R. yavapaiensis, demonstrating reduced MHC diversity in R. chiricahuensis. One allele was fixed in five populations but none of the R. chiricahuensis alleles were closely related to R. yavapaiensis allele Q, which is significantly associated with chytridiomycosis resistance in laboratory trials. Nine of 13 R. chiricahuensis population localities were Bd positive, and bearing allele RachDRB*04 was the best genetic predictor of an individual being infected with Bd. A total of three class IIβ alleles were recovered from captive reared individuals, which were released to two natural population localities followed by recapture surveys to assess MHC-based survival over winter, the time when chytridiomycosis outbreaks are most severe. At one site, all released animals were fixed for a single allele and MHC-based survival could not be assessed. At the second site, fewer than half of the released but all of the recaptured individuals were homozygous for RachDRB*05, indicating that MHC genotype is important in determining Bd survival under natural field conditions. We conclude that the limited MHC variation in R. chiricahuensis is likely the consequence rather than the cause of natural selection favoring alleles that promote survival in the face of Bd. Our study highlights that preserving even low levels of functional genetic variation may be essential for population persistence, and that local disease adaptation may present as a reduction in genetic diversity. These finding also suggest that for populations that have declined due to a specific infectious pathogen, MHC-based genetically-informed reintroduction approaches may enhance species recovery efforts

El bullying y/o violencia escolar en los niños y niñas entre 4 y 10 años en dos establecimientos particulares subvencionados de la región metropolitana

Tesis (Educación Parvularia, Licenciado en Educación)El acoso escolar siempre ha existido, sin embargo, desde algunos años atrás en Chile y el mundo se ha vuelto un fenómeno social. Los casos han sido ampliamente mediatizados y las escuelas han debido poner en marcha un plan para prevenirlo y controlarlo, que se ha integrado al Manual de Convivencia, nueva manera de exponer las normativas que regulan la convivencia y la disciplina interna de un establecimiento. Este tipo de violencia, la cual es permanente, entre pares, ha podido conocerse más gracias a la cobertura que los distintos medios de comunicación han dado a casos de especial gravedad, por las repercusiones que han tenido en algunos niños que han sido víctimas

Choque hipovolêmico por ruptura espontânea de átrio esquerdo em um felino: relato de caso

O objetivo do presente trabalho foi relatar um caso de choque hipovolêmico por ruptura de átrio esquerdo na região de aurícula em um felino de nove meses de idade, encaminhado para diagnóstico ao Laboratório de Patologia Veterinária da Universidade de Cruz Alta (LPV/UNICRUZ). O animal apresentava histórico de morte súbita, sendo relatado pelo tutor inquietação e agitação minutos antes da morte. Na inspeção externa do animal observou-se secreção sanguinolenta nas narinas e mucosas oral e ocular pálidas. Na abertura da cavidade torácica foi evidenciada grande quantidade de líquido sanguinolento e coágulos cruóricos, além de edema pulmonar e hemopericárdio. No saco pericárdico havia, ainda, uma perfuração onde fluía líquido sanguinolento. O átrio esquerdo apresentava parede fina e duas rupturas na região de aurícula. Foram coletados e fixados em formalina 10% tamponada fragmentos dos órgãos das cavidades torácica, abdominal e o encéfalo. Posteriormente, as amostras de tecido foram clivadas, processadas e coradas pela técnica de hematoxilina e eosina. O diagnóstico de choque hipovolêmico, por ruptura de átrio esquerdo, foi baseado no histórico e nos achados macroscópicos. Assim, destaca-se a importância desse trabalho em relatar um caso considerado incomum na medicina veterinária, a fim de contribuir com dados importantes para o estudo da etiologia e epidemiologia da ruptura cardíaca espontânea em felinos.</jats:p

Maternidade Prematura: A Experiência de Mães de Neonatos Internados na UTI Neonatal / Premature Maternity: The Experience of Mothers of Neonates Admitted to the Neonatal ICU

Resumo: A gravidez é um período de transição existencial, muito importante para o ciclo vital da mulher. Desse modo, um parto prematuro pode frustrar as expectativas maternas, provocando ansiedade e insegurança. Objetivou-se verificar a experiência de mães de neonatos pré-termos hospitalizados na unidade de terapia intensiva neonatal. Métodos: É uma pesquisa quantitativa, analítica e transversal, realizado com 90 mães. Os instrumentos utilizados foram, entrevista estruturada e questionário sociodemográfico e de saúde. Analisou-se a árvore de similitude gerada pelo software IRAMUTEQ. Resultados: evidenciaram a palavra medo como o léxico central relacionando-se: a hospitalização, cuidado com o filho e morte. Discussões: Verificou-se a espiritualidade, apoio social, e suporte da equipe de saúde, como fatores que podem contribuir positivamente para a puérpera. Conclusões: Por fim, ressalta-se a necessidade de um cuidado humanizado, com informações claras e fortalecimento do vínculo equipe-mãe-neonato.</jats:p