Neuroprotective effect of magnesium on lipid peroxidation and axonal function after experimental spinal cord injury

Study design: An experimental study examining the neuroprotective effect of magnesium on axonal function and lipid peroxidation in a rat model of acute traumatic spinal cord injury. Objective: To determine the effectiveness of postinjury treatment with magnesium on evoked potentials and lipid peroxidation after spinal cord injury (SCI). Setting: Pamukkale University, Denizli, Turkey. Methods: Spinal cord injury occurred in 30 rats with an aneurysm clip at T9 and the rats were randomly assigned to undergo subcutaneous administration of one of the following at 1 h after injury: (1) Physiological saline (n = 10); (2) MgSO4, 300 mg/kg (n = 10) and (3) MgSO4, 600 mg/kg (n = 10). Spinal somatosensory evoked potentials (SSEPs) were recorded before injury, 30 min after injury and 3 h after injections. Rats were killed 24 h after the injury, and malondialdehyde (MDA) levels were measured. Results: Following SCI, there were significant decreases in the amplitudes of P1 and N1 (P 0.001) and only high-dose magnesium improved the SSEPs (P < 0.01). On the other hand, there was significant difference in lipid peroxide content between high-dose magnesium treated group and both of saline treated and low-dose magnesium treated groups (P < 0.01). Conclusion: These results suggest that magnesium has a dose-dependent neuroprotective effect on SSEPs and lipid peroxidation after experimental spinal cord injury

EFFECT OF BROWN ALGAE (Sargassum Sp) GEL ON ALKALINE PHOSPHATASE LEVELS IN PERIODONTITIS RATS INDUCED BY SILK LIGATION MODEL

Introduction: Periodontitis is a chronic inflammatory disease caused by colonies of dysbiotic bacteria that form biofilms and cause destruction of the periodontal tissues. This damage can be induced by silk ligation on Sprague Dawley teeth and results in an increase in Alkaline Phosphate levels in the gingival sulcus. The purpose of this study was to determine the effect of brown algae extract gel (Sargassum sp) on reducing alkaline phosphatase levels in gingival sulcus fluid in Sprague Dawley periodontitis induced by silk ligation Material and Methods: This research is True Experimental with the Pre test - Post test Control Group Design. The research sample consisted of 36 male Wistar rats which were ligated with silk to periodontitis. Rats were divided into two groups (n=18), the control group was treated with Tie-es metronidazole gel plus and brown algae extract (Sargassum sp) gel treatment with a concentration of 75%. Sampling of gingival sulcus fluid (CSG) on days 0 and 5, ALP levels were measured using a UV/V is spectrophotometer with an absorbance of 450 nm. Results and Discussions: This study showed a decrease in ALP levels after being treated with metronidazole and 75% brown algae extract gel, the normal amount of ALP levels in the reference was 53-57 U/L and increased when inflammation occurred to 8283 U / L then a significant difference was obtained. The average reduction in ALP levels from pre test to post test for each group was 39-41  /L, and there was a significant relationship between giving brown algae extract and a decrease in ALP levels (p <0.05). Conclusion: Brown algae gel extract (Sargassum sp) concentration of 75% has a lowering effect on alkaline phosphatase levels of gingival sulcus fluid in periodontitis induced by silk ligatio

Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia

Extramedullary hematopoiesis associated with thalassemia causing spinal cord compression is an extremely rare event in the course of the disease. Documentation with an imaging technique, such as MRI, is mandatory. A patient with thalassemia intermedia, who developed paraparesis in spite of transfusion, underwent surgical decompression. Rapid neurological improvement was observed postoperatively and this neurological condition was protected with adequate hemoglobin level. Management of these patients remains controversial. Various modes of therapy such as surgical decompression, radiotherapy, and transfusion are discussed and the related literature is reviewed

Postoperative mutism after removal of an anterior falcine meningioma

Postoperative mutism is rare. We present a 65-year-old man who had transient mutism after resection of anterior falx meningioma. Mild left hemiparesis and palmomental reflex on the right were the only abnormal signs on neurological examination. CT scan and MRI demonstrated a mass at the anterior one-third portion of the falx just superior to the corpus callosum. The mass enhanced homogenously with administration of gadolinium DTPA. The patient underwent surgical resection of the lesion and adjacent falx cerebri. The operation was uneventful. On the second postoperative day he became mute. He could follow verbal commands, and write and read. Postoperative CT scan revealed a hypodense area in the right frontal lobe including a part of the anterior cingulate cortex and the anterior part of the corpus callosum. Histopathological examination revealed a mixed meningioma. Ten days postoperatively, he began to say simple words, and three weeks later he could talk normally. We consider that lesion of the supplementary motor area (SMA) may be responsible for postoperative mutism. (c) 2006 Published by Elsevier Ltd

Postoperative mutism after removal of an anterior falcine meningioma.

Postoperative mutism is rare. We present a 65-year-old man who had transient mutism after resection of anterior falx meningioma. Mild left hemiparesis and palmomental reflex on the right were the only abnormal signs on neurological examination. CT scan and MRI demonstrated a mass at the anterior one-third portion of the falx just superior to the corpus callosum. The mass enhanced homogenously with administration of gadolinium DTPA. The patient underwent surgical resection of the lesion and adjacent falx cerebri. The operation was uneventful. On the second postoperative day he became mute. He could follow verbal commands, and write and read. Postoperative CT scan revealed a hypodense area in the right frontal lobe including a part of the anterior cingulate cortex and the anterior part of the corpus callosum. Histopathological examination revealed a mixed meningioma. Ten days postoperatively, he began to say simple words, and three weeks later he could talk normally. We consider that lesion of the supplementary motor area (SMA) may be responsible for postoperative mutism

literature

OBJECTIVE AND IMPORTANCE: Intradural or intraradicular herniation of a lumbar disc is a rave complication of disc disease. The mechanism of the tearing of the dura mater by a herniated disc is not known with certainty. Only six cases of intraradicular disc herniation have been reported. By reporting the seventh case of this rare neurosurgical entity, we emphasize its importance and review the literature on intraradicular disc herniation

literature

OBJECTIVE AND IMPORTANCE: Intradural or intraradicular herniation of a lumbar disc is a rave complication of disc disease. The mechanism of the tearing of the dura mater by a herniated disc is not known with certainty. Only six cases of intraradicular disc herniation have been reported. By reporting the seventh case of this rare neurosurgical entity, we emphasize its importance and review the literature on intraradicular disc herniation

Intraradicular lumbar disc herniation: case report and review of the literature.

OBJECTIVE AND IMPORTANCE: Intradural or intraradicular herniation of a lumbar disc is a rare complication of disc disease. The mechanism of the tearing of the dura mater by a herniated disc is not known with certainty. Only six cases of intraradicular disc herniation have been reported. By reporting the seventh case of this rare neurosurgical entity, we emphasize its importance and review the literature on intraradicular disc herniation. CLINICAL PRESENTATION: A 41-year-old man was admitted with a 3-year history of low back pain and sciatica. A neurological examination revealed motor weakness during plantar flexion, positive Lasègue's sign, sensory deficit on the S1 dermatoma, and loss of Achilles reflex. Magnetic resonance imaging revealed disc protrusion at the L5-S1 level. Therefore, we decided to operate on the patient having made a diagnosis of lumbar disc disease. INTERVENTION: The patient underwent a standard hemilaminotomy and foraminotomy for a removal of the L5-S1 disc. There was no disc protrusion or extruded fragment. The left S1 nerve root was observed to be swollen and immobile. A longitudinal incision was made on the radicular sheet of the S1 root, and a free disc fragment, approximately 2 x 1 x 1 cm, was extirpated in one piece. CONCLUSION: The patient was immediately relieved of pain and was discharged on the 7th day after the operation with normal muscle strength. It seems probable that in some patients with "failed back syndrome," intraradicular or intradural disc herniation is the cause of failure