Preparation of 2 '-C-13-L-Histidine starting from C-13-Thiocyanate: synthetic access to any site-directed stable isotope enriched L-Histidine

Bio-organic Synthesi

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Corrosion inhibition of brass by triazoles

Benzotriazole (BTRA) and 2-mercaptotriazole (MTRA) have been used as corrosion inhibitors for (70/30) brass in 0.1 M HClO4. The inhibitor efficiency (P) calculated using weight loss, Tafel extrapolation, linear polarization and impedance methods was found to be in the order BTRA (â¼80) > MTRA (â¼55). The IR and CV studies have supported the contention that triazoles complex with brass. The SEM and EDAX study has confirmed the formation of a film on brass surface

Corrosion inhibition of brass by thiocarbamides

Thiocarbamides namely thiocarbamide (TC), ethylenethiocarbamide (ETC) and thiobenzamide (TBA) have been used as corrosion inhibitors for (70/30) brass in 0.1 M HClO4. The inhibitor efficiency ( P) calculated using weight loss, Tafel line extrapolation, linear polarization and impedance methods has been found to be in the ,order: TBA > ETC > TC. Thiocarbamides adsorbed on the electrode surface inhibited the corrosion of brass. They adsorb following Flory-Huggins isotherms. The number of water molecules displaced was found to increase with molecular size. TC, ETC and TBA displaced 3, 4 and 10 molecules and caused a distortion at the metal solution interface. The inhibitor molecule may form complexes with the dissolved Cu and Zn ions. This may result in the formation of a film