Experimental study of IR-signature of water ices between 1 and 2.5 µm : a thermal probe for icy moons

International audienc

Experimental study of the infrared IR-signature of water ices between 1 and 2.5 µm : application for icy moons

International audienc

In situ IR reflectance spectroscopy of clathrate hydrates at low and moderate pressures: application to icy moons

International audienc

Carbon dioxide clathrate hydrates at the surface of icy satellites Phoebe and Europa suggested by VIMS and NIMS reflectance spectra

International audienc

Clathrate hydrate of carbon dioxide above 0.2 GPa: new experimental results and theoretical developments

International audienc

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use