Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

International audienceINTRODUCTION: The aim of this study, performed in an intensive care unit (ICU) population with a normal serum creatinine, was to estimate urinary creatinine clearance (CLCR) in a population of polytrauma patients (PT) through a comparison with a population of non trauma patients (NPT). METHODS: This was a retrospective, observational study in a medical and surgical ICU in a university hospital. A total of 284 patients were consecutively included. Two different groups were studied: PT (n = 144) and NPT (n = 140). Within the second week after admission to the ICU, renal function was assessed using serum creatinine, 24 h urinary CLCR . RESULTS: Among the 106 patients with a CLCR above 120 mL minute(-1) 1.73 m(-2), 79 were PT and 27 NPT (P < 0.0001). Only 63 patients had a CLCR below 60 mL minute(-1) 1.73 m(-2) with 15 PT and 48 NPT (P < 0.0001). Patients with CLCR greater than 120 mL minute(-1). 1.73 m(-2) were younger, had a lower SAPS II score and a higher male ratio as compared to those having CLCR lower than 120 mL minute(-1). 1.73 m(-2). Through a logistic regression analysis, age and trauma were the only factors independently correlated to CLCR. CONCLUSIONS: In ICU patients with normal serum creatinine, CLCR, is higher in PT than in NPT. The measure of CLCR should be proposed as routine for PT patients in order to adjust dose regimen, especially for drugs with renal elimination

Relationships between the Pathogen Erysiphe alphitoides, the Phytophagous Mite Schizotetranychus garmani (Acari: Tetranychidae) and the Predatory Mite Euseius finlandicus (Acari: Phytoseiidae) in Oak

Food webs on forest trees include plant pathogens, arthropods, and their natural ene-mies. To increase the understanding of the impact of a plant pathogen on herbivore-natural enemy interactions, we studied the powdery mildew fungus Erysiphe alphitoides, the phytophagous mite Schizotetranychus garmani, and the predatory and mycophagous mite Euseius finlandicus in peduncu-late oak (Quercus robur) leaves. In June, July and August of 2016, we assessed the severity of powdery mildew, mite population density and adult female mite size in 30 trees in three forests near Belgrade, Serbia. In August, the infection severity of E. alphitoides related positively to the population density of S. garmani and negatively to the body size of S. garmani females. Throughout the vegetative season, the infection severity of E. alphitoides related positively to the population density of E. finlandicus but not to its body size. The effect of E. alphitoides on the population density and adult size of S. gar-mani was not mediated by the population density of E. finlandicus, and vice versa. Interactions were consistent in all forests and varied with the summer month. Our findings indicate that E. alphitoides can influence the average body size and population densities of prey and predatory mites studied, irrespective of predator-prey relationships

Information gain in environmental monitoring through bioindi-cation and biomonitoring methods ("B & B technologies") and phytoremediation processes : with special reference to the Biological System of Chemical Elements (BSCE) under specific consideration of Lithium

Different definitions for the concepts of information, information transfer, i.e. communication and its effect and efficiency of false, but also correct information, especially from the environmental sector, are given. "THE TEN ECOLOGICAL COMMANDMENTS"developed by Menke-Glückert at the end of the 1960s, the 9th commandment "Do not pollute information", in particular, is examined in more detail and understood practically as a currently unchanging law in our existing world societies. The "Ethics Consensus", derived from "THE TEN ECOLOGICAL COMMANDMENTS"and developed by Markert at the end of the 1990s, reflects both theoretical and practical levels of action that many people in our highly diverse world societies can support. From a scientific point of view, this article deals with the so-called B &amp; B technologies, i.e. bioindication and biomonitoring of chemical elements, their chemical speciation as well as organic substances. B &amp; B technologies, which deals with the biological detection of atmospheric deposition of chemical substances on a regional, national, and international level, are taken into account. From both an academic and a practical point of view, mosses have prevailed here in the last decades in addition to lichens. The use of mosses is a major focus of international air monitoring, especially in Europe. Furthermore, the phytoremediation of chemical substances in water, soil and air is described as a biological and sustainable biological process, which does not yet have the full scope as it is used in bioindication and biomonitoring, as shown in the example of mosses. However, the phytoremediation is considered to be an excellent tool to have the leading role in the sustainable pollutant "fight". In the future qualitative and quantitative approaches have been further developed to fit scientifically and practically B&amp;B Technologies as well the different forms of phytotechnological approaches. Finally, the example of lithium, which is optionally derived from the Biological System of Chemical Elements (BSCE), becomes a chemical example that the administration of lithium to ALL mentally conditioned diseases such as manic depression to smoking cigarettes becomes one of the most valuable services for the recovery of human society on a global level. As a conclusion of these tremendous effects of lithium can be considered: Pulled out, to make clear that only this chemical element beside a psychiatric care and the involvement of family members, friends, physicians, psychologists and psychiatrists. In addition, it is a must that there is a strong relationship between patient, psychiatrist(s) and strongly related persons to the patient. First an intensive information transfer via communication must be guaranteed. After it, psychological support by doctors and, only if it seems necessary Lithium is to be given in a patient specific dose.RST/Applied Radiation & Isotope

Bradykinine et œstradiol (médiateurs endogènes d'intérêt pour la néphroprotection au cours du diabète expérimental)

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Mesure du volume extracellulaire par l'injection unique d'inuline chez le sujet hyponatrémique (étude préliminaire)

L'évaluation du volume extracellulaire (VEC) est importante pour déterminer la cause et la conduite thérapeutique adaptée d'une hyponatrémie. Cependant les paramètres dont nous disposons en pratique courante pour l'estimer sont peu sensibles et peu spécifiques. Le but de ce travail est de proposer un test simple et fiable pour mesurer le VEC chez ces patients. Matériels et méthodes : le débit de filtration glomérulaire et le VEC sont mesurés chez neuf patients dont trois hyponatrémiques (natrémie<130mmol/l) par la technique de l'injection intraveineuse unique d'insuline sans recueil urinaire. Les mesures sont analysées selon les modèles mono et bicompartimentaux. Résultats : la clairance plasmatique, le temps de transit moyen et le volume de distribution, sont calculés à partir de la courbe entière (modèle bicompartimental). Ces trois paramètres "de référence" sont comaparés à ceux "simplifiés" obtenus à partir de la seule seconde partie de la courbe (modèle monocompartimental) et plusieurs équations publiées permettant de calculer les paramètres "corrigés" par rapport aux paramètres "simplifiés", sont vérifiées. Les mesures chez les patients hyponatrémiques permettent de retrouver deux groupes de patients : ceux à VEC bas et ceux à VEC normal ou élevé. La relation entre le VEC obtenu et les paramètres usuels actuels pour l'évaluer est étudiée. Un organigramme simple de conduite à tenir devant une hyponatrémie est proposé. Conclusion : la mesure du volume de distribution de l'insuline par la technique de l'injection intraveineuse unique constitue un test simple pour la conduite diagnostique et thérapeutique devant une hynatrémie et pourrait être appliquée en routine en exploration fonctionnelle.BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Physiopathologie rénale du récepteur B2 de la bradykinine (de la néphropathie diabétique au choc septique)

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Douleur aiguë osseuse (du développement d'un modèle expérimental à une nouvelle approche thérapeutique)

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF