Prospect for new guidance in the design of FRP

Over the last twenty years, many innovative solutions have confirmed the usefulness of composite structures realized with FRPs (Fibre Reinforced Polymer or Plastic). The need of European standards for use of fibre-reinforced polymer composites in civil engineering was justified in 2007 in the JRC Report EUR 22864 EN. The new European technical rules will be developed using the existing organization of CEN/TC250. The present report has been worked out in the frame of CEN/TC250/WG4 activities. The report encompasses: • Part I, which introduces the policy framework and the CEN/TC250 initiative • Part II, which gives a prospect for CEN guidance for the design and verification of composite structures realized with FRPs The report presents scientific and technical background intended to stimulate debate and serves as a basis for further work to achieve a harmonized European view on the design and verification of such structures. This has been the main impulse to include the work item of the Fibre Reinforced Polymer Structures in the Mandate M/515 with high priority.JRC.G.4-European laboratory for structural assessmen

Emergence of NDM-1-producing Enterobacteriaceae in China

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A scalable xeno-free microcarrier suspension bioreactor system for regenerative medicine biomanufacturing of hMSCs

An economical biomanufacturing paradigm for human mesenchymal stem/stromal cells (hMSCs) is in critical need, as indicated by over 800 clinical trials investigating the use of hMSCs for regenerative medicine. To meet the demand for clinical manufacturing, a scalable process and production technology platform that can generate billions to trillions of cells per manufacturing lot is needed. Suspension bioreactors show great promise in reaching commercially-viable working volumes, however, scalability of cell production remains an issue. Overcoming this challenge is necessary to drive widespread adoption of this culture system for hMSCs. We have taken the Quality by Design (QbD) approach to develop a scalable xeno-free (XF) hMSC bioreactor process that maintains the final cell population doubling level (PDL) within the recommended range of 16-20 to ensure product quality. Our strategic XF bioprocess was designed using high volume XF cell banks, an optimized XF fed-batch media system, and XF microcarriers, all combined in a scalable bioreactor system to meet our design criteria and streamlined production at different culture scales. Please click Additional Files below to see the full abstract

Prospect for new guidance in the design of FRP : support to the implementation and further development of the Eurocode

Over the last twenty years, many innovative solutions have confirmed the usefulness of composite structures realized with FRPs (Fibre Reinforced Polymer or Plastic). The need of European standards for use of fibre-reinforced polymer composites in civil engineering was justified in 2007 in the JRC Report EUR 22864 EN. The new European technical rules will be developed using the existing organization of CEN/TC250. The present report has been worked out in the frame of CEN/TC250/WG4 activities. The report encompasses: • Part I, which introduces the policy framework and the CEN/TC250 initiative • Part II, which gives a prospect for CEN guidance for the design and verification of composite structures realized with FRPs The report presents scientific and technical background intended to stimulate debate and serves as a basis for further work to achieve a harmonized European view on the design and verification of such structures. This has been the main impulse to include the work item of the Fibre Reinforced Polymer Structures in the Mandate M/515 with high priority