Cocycle Properties of String Theories on Orbifolds

We study cocycle properties of vertex operators and present an operator representation of cocycle operators, which are attached to vertex operators to ensure the duality of amplitudes. It is shown that this analysis makes it possible to obtain the general class of consistent string theories on orbifolds.Comment: 40 pages (Talk given at Workshop on ``Recent Developments in String and Field theory", Kyoto, Japan on September 9-12, 1991.

Distribution of Mid Vowels and Relating Vowel Harmony in Zulu

This paper focuses on the distribution of mid vowels in Zulu and how the language system treats them.In this language, mid-low vowels such as [ɛ] and [ɔ] are raised to mid-high position as [e] and [o], when directly followed by a syllable with a high vowel. This paper attempts to analyze how raising happens focusing on [ATR] feature, and looks at cases which have not been studied in depth, such as whether the harmony iteratively occurs in the cases where a syllable with another mid vowel exists before the target mid vowel, or how a glide sound affects the harmony pattern. The analysis is given in terms of both Rule-based Theory and Optimality Theory. This paper has found that the vowel harmony regarding the mid vowels is non-iterative, and also found that a glide sound cannot be a trigger for the harmony

An Authentication Method for Digital Audio Using a Discrete Wavelet Transform Abstract

Recently, several digital watermarking techniques have been proposed for hiding data in the frequency domain of audio files in order to protect their copyrights. In general, there is a tradeoff between the quality of watermarked audio and the tolerance of watermarks to signal processing methods, such as compression. In previous research, we simultaneously improved the performance of both by developing a multipurpose optimization problem for deciding the positions of watermarks in the frequency domain of audio data and obtaining a near-optimum solution to the problem. This solution was obtained using a wavelet transform and a genetic algorithm. However, obtaining the near-optimum solution was very time consuming. To overcome this issue essentially, we have developed an authentication method for digital audio using a discrete wavelet transform. In contrast to digital watermarking, no additional information is inserted into the original audio by the proposed method, and the audio is authenticated using features extracted by the wavelet transform and characteristic coding in the proposed method. Accordingly, one can always use copyright-protected original audio. The experimental results show that the method has high tolerance of authentication to all types of MP3, AAC, and WMA compression. In addition, the processing time of the method is acceptable for everyday use

Modelling the Establishment of PAR Protein Polarity in the One-Cell C. elegans Embryo

At the one-cell stage, the C. elegans embryo becomes polarized along the anterior-posterior axis. The PAR proteins form complementary anterior and posterior domains in a dynamic process driven by cytoskeletal rearrangement. Initially, the PAR proteins are uniformly distributed throughout the embryo. Following a cue from fertilization, cortical actomyosin contracts towards the anterior pole. PAR-3/PAR-6/PKC-3 (the anterior PAR proteins) become restricted to the anterior cortex. PAR-1 and PAR-2 (the posterior PAR proteins) become enriched in the posterior cortical region. We present a mathematical model of this polarity establishment process, in which we take a novel approach to combine reaction-diffusion dynamics of the PAR proteins coupled to a simple model of actomyosin contraction. We show that known interactions between the PAR proteins are sufficient to explain many aspects of the observed cortical PAR dynamics in both wild-type and mutant embryos. However, cytoplasmic PAR protein polarity, which is vital for generating daughter cells with distinct molecular components, cannot be properly explained within such a framework. We therefore consider additional mechanisms that can reproduce the proper cytoplasmic polarity. In particular we predict that cytoskeletal asymmetry in the cytoplasm, in addition to the cortical actomyosin asymmetry, is a critical determinant of PAR protein localization.Comment: 28 pages, 8 figure

Symmetries between Untwisted and Twisted Strings on Asymmetric Orbifolds

We study symmetries between untwisted and twisted strings on asymmetric orbifolds. We present a list of asymmetric orbifold models to possess intertwining currents which convert untwisted string states to twisted ones, and vice versa. We also present a list of heterotic strings on asymmetric orbifolds with supersymmetry between untwisted and twisted string states. Some of properties inherent in asymmetric orbifolds, which are not shared by symmetric orbifolds, are pointed out.Comment: Plain Tex, 35 pages, NBI-HE-92-34, KOBE-92-0

Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells

<p>Abstract</p> <p>Background</p> <p><it>HOX </it>genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. They also behave as oncogenes in some malignancies.</p> <p>Results</p> <p>In this study, we found high expression of the <it>HOXD9 </it>gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. To investigate the role of <it>HOXD9 </it>in gliomas, we silenced its expression in the glioma cell line U87 using <it>HOXD9</it>-specific siRNA, and observed decreased cell proliferation, cell cycle arrest, and induction of apoptosis. It was suggested that <it>HOXD9 </it>contributes to both cell proliferation and/or cell survival. The <it>HOXD9 </it>gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. <it>HOXD9 </it>siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of <it>HOXD9 </it>in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs).</p> <p>Conclusions</p> <p>Our results suggest that <it>HOXD9 </it>may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target.</p