Organised crime and public sector corruption

Foreword: In 2006, the Australian Government introduced the Anti-money Laundering and Counter-Terrorism Financing Act 2006 (Cth) which increased regulatory controls over businesses potentially able to facilitate organised criminal activities such as money laundering. The implementation of tougher legislation and associated law enforcement interventions may result in criminal organisations adjusting their tactics in order to continue their activities without detection. In this paper, the risk and potential impact of tactical displacement by organised criminals is discussed with regard to the potential for increased attempts by organised crime groups to corrupt public servants. There is a paucity of research exploring the nature and extent of public sector corruption committed by organised crime groups. This discussion is informed by literature on ‘crime scripts’ originally developed by Cornish (1994) and the 5I’s crime prevention framework developed by Ekblom (2011). Making use of public-source information about the commission of such crimes, as exemplified in two recent corruption cases, some intervention strategies are proposed that may be effective in reducing the risks of corruption of public sector officials by organised crime groups in Australia

Organised crime and public sector corruption: a crime scripts analysis of tactical displacement risks

Organised crime in Australia has received increased attention over the last decade, with the enactment of legislation and the development of other interventions that have sought to control this serious criminal phenomenon. Although the success of such interventions in reducing organised crime is yet to be subject to detailed evaluation, prior research has identified certain risks associated with policy responses that could, arguably, also lead to counterproductive consequences (Guerette & Bowers 2009; Smith, Wolanin & Worthington 2003). One consequence of enhanced legislation and/or law enforcement approaches developed to combat organised crime is so-called ‘tactical crime displacement’, namely that criminals may modify their tactics in order to circumvent the effects of new legislation or increased law enforcement activity, thus allowing them to continue to offend with a reduced risk of detection or criminal justice action taking place. One particular risk of tactical crime displacement is the potential for organised crime groups to focus more on forming corrupt relationships with public officials in order to obtain information that minimises the risk of detection and prosecution. This paper illustrates how organised criminal groups can alter their patterns of offending by inducing public officials into corruptly disclosing information relevant to the facilitation of further criminal activity. This process of corruption is explained using the notion of ‘crime scripts’, as developed by Cornish (1994), and applied in the context of organised crime. Following an analysis of the crime scripts used by organised criminals in relation to the corruption of public servants in selected cases in Australia, various situational crime prevention solutions based on Ekblom’s (2011) 5Is approach to crime prevention are explored as potential ways in which to minimise risks of this nature

MultiPlaneNeRF: Neural Radiance Field with Non-Trainable Representation

NeRF is a popular model that efficiently represents 3D objects from 2D images. However, vanilla NeRF has some important limitations. NeRF must be trained on each object separately. The training time is long since we encode the object's shape and color in neural network weights. Moreover, NeRF does not generalize well to unseen data. In this paper, we present MultiPlaneNeRF -- a model that simultaneously solves the above problems. Our model works directly on 2D images. We project 3D points on 2D images to produce non-trainable representations. The projection step is not parametrized and a very shallow decoder can efficiently process the representation. Furthermore, we can train MultiPlaneNeRF on a large data set and force our implicit decoder to generalize across many objects. Consequently, we can only replace the 2D images (without additional training) to produce a NeRF representation of the new object. In the experimental section, we demonstrate that MultiPlaneNeRF achieves results comparable to state-of-the-art models for synthesizing new views and has generalization properties. Additionally, MultiPlane decoder can be used as a component in large generative models like GANs

The role of disulfide bond replacements in analogues of the Tarantula toxin ProTx-II and their effects on inhibition of the voltage-gated sodium ion channel Nav1.7

Spider venom toxins, such as Protoxin-II (ProTx-II), have recently received much attention as selective Nav1.7 channel blockers, with potential to be developed as leads for the treatment of chronic nocioceptive pain. ProTx-II is a 30-amino acid peptide with three disulfide bonds that has been reported to adopt a well-defined inhibitory cystine knot (ICK) scaffold structure. Potential drawbacks with such peptides include poor pharmacodynamics and potential scrambling of the disulfide bonds in vivo. In order to address these issues, in the present study we report the solid-phase synthesis of lanthionine-bridged analogues of ProTx-II, in which one of the three disulfide bridges is replaced with a thioether linkage, and evaluate the biological properties of these analogues. We have also investigated the folding and disulfide bridging patterns arising from different methods of oxidation of the linear peptide precursor. Finally, we report the X-ray crystal structure of ProTx-II to atomic resolution; to our knowledge this is the first crystal structure of an ICK spider venom peptide not bound to a substrate

Radio AGN in spiral galaxies

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.Radio AGN in the nearby Universe are more likely to be found in galaxies with early-type morphology, the detection rate in spiral or late-type galaxies (LTGs) being around an order of magnitude lower. We combine the mJy Imaging VLBA Exploration at 20cm (mJIVE-20) survey with the Sloan Digital Sky Survey (SDSS), to study the relatively rare population of AGN in LTGs that have nuclear radio luminosities similar to that in their early-type counterparts. The LTG AGN population is preferentially hosted by galaxies that have high stellar masses (M* > 10^10.8 MSun), red colours and low star-formation rates, with little dependence on the detailed morphology or local environment of the host LTG. The merger fraction in the LTG AGN is around 4 times higher than that in the general LTG population, indicating that merging is an important trigger for radio AGN in these systems. The red colours of our systems extend recent work which indicates that merger-triggered AGN in the nearby Universe appear after the peak of the associated starburst, implying that they do not strongly regulate star formation. Finally, we find that in systems where parsec-scale jets are clearly observed in our VLBI images, the jets are perpendicular to the major axis of the galaxy, indicating alignment between the accretion disc and the host galaxy stellar disc.Peer reviewe

Tracheal cancers

Primary tracheal tumors are very rare and the literature on this subject is limited. Due to their rarity and diversity, the provision of patient care in terms of optimal management poses a considerable challenge. There are no unequivocal guidelines concerning the treatment in patients with local or distant disease. The most common types of primary tracheal tumors are squamous cell carcinoma and adenoid cystic carcinoma. Squamous cell carcinoma of the trachea is 2–4 times more common in men than in women and develops primarily in the sixth and seventh decades of life. It is strongly associated with tobacco smoking. Adenoid cystic carcinoma of the trachea occurs with similar frequency in men and women, and is most common in the fourth and fifth decades of life. The etiology of this type is unknown, however it is not associated with tobacco smoking. Adenoid cystic carcinoma is characterized by submucosal and perineural spread. Treatment of patients with primary tracheal tumors requires a multidisciplinary approach. Optimal treatment of localized tumors is based on surgery or radiotherapy. If distant metastases are present the therapeutic palliative methods are: chemotherapy, palliative radiotherapy or palliative surgery. The prognosis of patients with primary tracheal tumors is determined by several factors. Histological diagnosis of adenoid cystic carcinoma, good performance status, and complete resection have been identified as favorable prognostic factors. Despite intensive treatment, the 5-year survival rate for primary tracheal tumors is not satisfactory

Fluorescent logic systems for sensing and molecular computation: structure–activity relationships in edge-detection

Molecular logic-based computation continues to throw up new applications in sensing and switching, the newest of which is the edge detection of objects. The scope of this phenomenon is mapped out by the use of structure-activity relationships, where several structures of the molecules and of the objects are examined. The different angles and curvatures of the objects are followed with good-fidelity in the visualized edges, even when the objects are in reverse video

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Objective: The HOME BP (Home and Online Management and Evaluation of Blood Pressure) trial aimed to test a digital intervention for hypertension management in primary care by combining self-monitoring of blood pressure with guided self-management. Design: Unmasked randomised controlled trial with automated ascertainment of primary endpoint. Setting: 76 general practices in the United Kingdom. Participants: 622 people with treated but poorly controlled hypertension (>140/90 mm Hg) and access to the internet. Interventions: Participants were randomised by using a minimisation algorithm to self-monitoring of blood pressure with a digital intervention (305 participants) or usual care (routine hypertension care, with appointments and drug changes made at the discretion of the general practitioner; 317 participants). The digital intervention provided feedback of blood pressure results to patients and professionals with optional lifestyle advice and motivational support. Target blood pressure for hypertension, diabetes, and people aged 80 or older followed UK national guidelines. Main outcome measures: The primary outcome was the difference in systolic blood pressure (mean of second and third readings) after one year, adjusted for baseline blood pressure, blood pressure target, age, and practice, with multiple imputation for missing values. Results: After one year, data were available from 552 participants (88.6%) with imputation for the remaining 70 participants (11.4%). Mean blood pressure dropped from 151.7/86.4 to 138.4/80.2 mm Hg in the intervention group and from 151.6/85.3 to 141.8/79.8 mm Hg in the usual care group, giving a mean difference in systolic blood pressure of −3.4 mm Hg (95% confidence interval −6.1 to −0.8 mm Hg) and a mean difference in diastolic blood pressure of −0.5 mm Hg (−1.9 to 0.9 mm Hg). Results were comparable in the complete case analysis and adverse effects were similar between groups. Within trial costs showed an incremental cost effectiveness ratio of £11 ($15, €12; 95% confidence interval £6 to £29) per mm Hg reduction. Conclusions: The HOME BP digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs. Implementation in primary care will require integration into clinical workflows and consideration of people who are digitally excluded. Trial registration: ISRCTN13790648