Effect of garlic (Allium sativum) on male fertility: a systematic review

Introduction: Fertility in men mainly depends on the number, quality, motility, and morphology of the sperms, and disruption of each of these factors leads to infertility. A large number of couples suffer from infertility problems. Among the various therapies, medicinal herbs are used in many countries to treat male infertility. Current systematic review was conducted to study the effects of garlic on male fertility. Methods: The information of this systematic review was collected by searching the key words: treatment, fertility, infertility, male, herbal medicine, garlic, Allium sativum, medicinal plant, sperm, sex hormones, testis and spermatogenesis in international databases such as: Web of Science (ISI), PubMed, Scopus and Embase until March 2018. This study was conducted in accordance with the PRISMA statement for systematic reviews and meta- analysis. and the SYRCLE risk of bias tool was used for qualitative assessment. Results: A total of 18 experimental studies were included in the study. Thirteen studies evaluated garlic and 5 studies compared garlic effect with adriamycin, titanium dioxide, furan, vitamin E, N-acetylcysteine and cadmium. All studies were conducted in in vivo condition. The results of the studies indicated the potential effect of garlic on enhancing fertility and spermatogenesis, increasing the level of testosterone and improving the testicular structure. Conclusion: Garlic can increase fertility probably due to its antioxidant properties. However, more clinical trials are recommended

Effect of garlic (Allium sativum) on male fertility: a systematic review

Introduction: Fertility in men mainly depends on the number, quality, motility, and morphology of the sperms, and disruption of each of these factors leads to infertility. A large number of couples suffer from infertility problems. Among the various therapies, medicinal herbs are used in many countries to treat male infertility. Current systematic review was conducted to study the effects of garlic on male fertility. Methods: The information of this systematic review was collected by searching the key words: treatment, fertility, infertility, male, herbal medicine, garlic, Allium sativum, medicinal plant, sperm, sex hormones, testis and spermatogenesis in international databases such as: Web of Science (ISI), PubMed, Scopus and Embase until March 2018. This study was conducted in accordance with the PRISMA statement for systematic reviews and meta- analysis. and the SYRCLE risk of bias tool was used for qualitative assessment. Results: A total of 18 experimental studies were included in the study. Thirteen studies evaluated garlic and 5 studies compared garlic effect with adriamycin, titanium dioxide, furan, vitamin E, N-acetylcysteine and cadmium. All studies were conducted in in vivo condition. The results of the studies indicated the potential effect of garlic on enhancing fertility and spermatogenesis, increasing the level of testosterone and improving the testicular structure. Conclusion: Garlic can increase fertility probably due to its antioxidant properties. However, more clinical trials are recommended

The investigation of the relationship between polycystic ovary syndrome with metabolic changes in women

Background: For exploring the relationship between metabolic changes and thyroid function in polycystic ovary syndrome (PCOS) patients, metabolic, endocrine, and thyroid parameters were assessed. Materials and Methods: alterations in endocrine, metabolic, and clinical characteristics in PCOS patients compared with healthy women were studied within a prospective investigation. Also thyroid parameters were considered. Results: 300 women with normal ovulatory as controls and PCOS patients were included and matched by age. There were significant increases in triglyceride (TG), cholesterol (CHL), and total dihydrotestosterone (DHT) in PCOS patients. Also, overall levels of Fast Blood Sugar (FBS), Follicle-stimulating hormone (FSH), Testosterone (T), Prolactin, and thyroid-stimulating hormone (TSH) were higher in compared with the normal women, but these higher amounts were not significant. There was an insignificant decrease in Luteinizing hormone(LH), high-density lipoprotein (HDL), and Free T4 in PCOS patients compared with the controls. Conclusions: Our manuscript suggests the negative metabolic alterations in PCOS patients.The small increases of TG, CHL, and DHT levels may depend on these alterations in metabolic parameters in PCOS patients. Further investigations may clear a vague understanding of the relationship between metabolic parameters alteration and thyroid function