The investigation of the relationship between polycystic ovary syndrome with metabolic changes in women

Abstract

Background: For exploring the relationship between metabolic changes and thyroid function in polycystic ovary syndrome (PCOS) patients, metabolic, endocrine, and thyroid parameters were assessed. Materials and Methods: alterations in endocrine, metabolic, and clinical characteristics in PCOS patients compared with healthy women were studied within a prospective investigation. Also thyroid parameters were considered. Results: 300 women with normal ovulatory as controls and PCOS patients were included and matched by age. There were significant increases in triglyceride (TG), cholesterol (CHL), and total dihydrotestosterone (DHT) in PCOS patients. Also, overall levels of Fast Blood Sugar (FBS), Follicle-stimulating hormone (FSH), Testosterone (T), Prolactin, and thyroid-stimulating hormone (TSH) were higher in compared with the normal women, but these higher amounts were not significant. There was an insignificant decrease in Luteinizing hormone(LH), high-density lipoprotein (HDL), and Free T4 in PCOS patients compared with the controls. Conclusions: Our manuscript suggests the negative metabolic alterations in PCOS patients.The small increases of TG, CHL, and DHT levels may depend on these alterations in metabolic parameters in PCOS patients. Further investigations may clear a vague understanding of the relationship between metabolic parameters alteration and thyroid function