Saponins, tannins and flavonols found in hydroethanolic extract from Periandra dulcis roots

Periandra dulcis Mart. ex Benth. Fabaceae (Syn.: P. mediterranea (Vell.) Taub.) is native to the northern and middle parts of Brazil. In Brazilian ethnomedicine, their roots are used as anti inflammatory, expectorant, diuretic and laxative. An HPLC-ESI-MS/MS system was employed to provide a rapid method to make a tentative characterization of the compounds found in the hydroethanolic extract from P. dulcis roots. The structures of sixteen compounds found in this hydroethanolic extract were suggested mainly by MS data conjugated with the UVDAD spectra, reference compounds and available mass spectra data in literature. Saponin derivatives of hederagenin and soyasapogenol E, such as hederagenin-3-O-rhamnosyl glucosyl glucuronide, soyasapogenol E-3-O-rhamnosyl glucosyl glucuronide and periandrin isomers were found as the main constituents, with a minor content of flavonols quercetin and myricetin glycosides derivatives and hydrolysable tannins, such as dihexahydroxydiphenoyl galloyl glucoside and trisgalloyl hexahydroxydiphenoyl glucose.To the best of our knowledge, with exception of periandrins found in the roots, nothing has been published about the chemical composition of P. dulcis..Universidade Federal de São Paulo (UNIFESP) Departamento de PsicobiologiaUNIFESP, Depto. de PsicobiologiaSciEL

Incorporating use case testing into a design tool

Describes a design tool that checks the dynamic behaviour of a design based on use cases. The tool enables system designers to check both the static and dynamic integrity of their designs for object-oriented analysis

ERME column

In this contribution we introduce three classical theoretical stances within the field of mathematics education regarding representations. Our aim is to highlight what we consider to be an interesting shift in how representations are conceived and studied in the field of mathematics education, and how this could impact both the practice of teaching and learning mathematics, and on further theorizing mathematical representation. We also indicate potential directions in which to develop ways to talk about newer forms of dynamic interactive representation

Purchasing Management in an International Company

Import 02/11/2016Tato práce pojednává o řízení nákupního oddělení v mezinárodní výrobní společnosti. Cílem je popsat si silné a slabé stránky, uvést konkrétní příklady a také návrhy na zlepšení. V závěru práce jsou shrnuty jednotlivé kroky, které pomohou zefektivnit jak chod oddělení tak zvýší konkurenceschopnost celé firmy díky nižším nákladům. Jedná se o efektivnější motivaci a zadávání cílů, zlepšení komunikace a způsob fixování nákupních cen v delším časovém období.this document is about how to lead purchasing department in an international manufacturing company. Target was describe strength and weak points, show specific examples and also suggest improvements. At the end of document is summary of each steps, which are helping to improve purchasing department and also will increase competitivnes of whole company through cost reduction. It is more efficient motivation and target setting, improve communication and way of fixing purchasing prices in longer time period.152 - Katedra podnikohospodářskávelmi dobř

IT Governance Impact on Business Unit Performance

The main objective of this thesis is to investigate the impact and role of implementing information technology (IT) governance practices on the business value driven from IT. The proposed research model encompasses the use of configurational theory in order to find different gestalts of IT governance practices. This research also looks at the links between these gestalts and the performance of business units from a financial and non-financial perspective. To test the model, 57 matched surveys were collected from North America and the Middle East. Different clusters of IT governance practices have emerged from this study with distinct yet significant impact on business unit non-financial performance. However, no significant impact on the business unit financial performance was found. The findings show that implementing different sets of IT governance practices within organizations can result in different levels of performance at the business unit level in terms of business processes, decision making and legal and ethical compliance

Flavonóides glicosídeos encontrados no extrato hidroalcoólico de Tilia cordata, espécie usada como ansiolítico

Tilia species, among which is Tilia cordata Mill. (Tiliaceae), have been used in folk medicine as anxiolytic. The hydroethanolic extract was analyzed by using liquid chromatography with mass spectrometry HPLC-DAD-ESI-MS/MS in negative ion mode, and its chemical composition was compared to flavonoids reported as anxiolytics. The major flavonoids found were: quercetin-3,7-di-O-rhamnoside, kaempferol-3,7-di-O-rhamnoside and kaempferol 3-O-(6-p-coumaroyl glucoside) or tiliroside. The anxiolytic activity of the genus Tilia has been attributed to the presence of quercetin and kaempferol derivatives, while the anxiolytic activity of T. americana var. Mexicana was attributed to tiliroside, which was also found among the major constituents of this species.As espécies de Tilia, entre elas, a Tilia cordata Mill. (Tiliaceae) são utilizadas como ansiolíticas na medicina popular. O extrato hidroalcoólico foi analisado usando cromatografia líquida acoplada à espectrometria de massas HPLC-DAD-ESI/MS/MS no modo negativo e a sua composição química foi comparada com os flavonóides já reportados como ansiolíticos. Os principais flavonóides encontrados foram: quercetina-3,7-di-O-rhamnosideo, canferol-3,7-di-O-rhamnosideo, e canferol 3-O-(6-p-cumaroil glucosideo) ou tilirosideo. A atividade ansiolítica do gênero Tília tem sido atribuída à presença de derivados de canferol e quercetina, enquanto que a atividade ansiolítica da T. americana var. Mexicana foi atribuída ao tilirosideo, o qual também foi encontrado entre os principais constituintes desta espécie.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Federal University of São Paulo Department of PsychobiologyUNIFESP, Department of PsychobiologySciEL