Blok şifrelerin olası olmayan diferansiyel kriptanalizi

TÜBİTAK EEEAG Proje01.10.201

Modelling Porosity Permeability of Ceramic Tiles using Fuzzy Taguchi Method

Taguchi experiment design in quality development studies, is an approach to engineering that supports research and development, product design and product development activities by enabling fewer trials of experiments to determine the best combinations of inputs that affect the outcome. In this study, the factors affecting the porosity were studied in a firm that produces ceramic tile. There were 6 factors considered to be important in total and 2 levels in each factor. L8 orthogonal array were used during the experiment design, which proposes 8 experiment types with different factor levels. The results of the experiments were analyzed so that important factors were determined. Significance of factors were tested by ANOVA and 4 of them were found to be significant. These factors were fuzzified by assessing the factors using linguistic expressions and then triangular fuzzy numbers. A model with 4 inputs and 1 output was built and 34 rules were generated for this model. The developed model was shown to be a useful approach in modeling the porosity permeability of ceramic tiles

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we discovered a molecule (M47) that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo. The M47 selectively enhanced the degradation rate of CRY1 by increasing its ubiquitination and resulted in increasing the circadian period length of U2OS Bmal1-dLuc cells. In addition, subcellular fractionation studies from mice liver indicated that M47 increased degradation of the CRY1 in the nucleus. Furthermore, M47-mediated CRY1 reduction enhanced oxaliplatin-induced apoptosis in Ras-transformed p53 null fibroblast cells. Systemic repetitive administration of M47 increased the median lifespan of p53−/− mice by ~25%. Collectively our data suggest that M47 is a promising molecule to treat forms of cancer depending on the p53 mutation

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels >2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p < 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168

TMVÇ tabanlı verimli asal cisim çarpması gerçeklemesi ve eliptik eğri kriptografi’ye uygulamaları.

The need for faster and practical cryptography is a research topic for decades. For elliptic curve cryptography, which is proposed independently by Koblitz and Miller in 1985 as a more efficient alternative to RSA, the applications of it in real life started after 2000s. Today, most of the popular applications and protocols like Whatsapp, Signal, iOS, Android, TLS, SSH, Bitcoin etc. make use of elliptic curve cryptography. In this thesis, we present a new representation of finite field multiplication which is one of the basic building blocks for the ECC using Toeplitz matrix-vector product (TMVP) and discuss its arithmetic cost and comparison. In addition, we evaluate the delay complexity of the proposed algorithm when computations are performed using multi-core systems. We also describe how to choose proper prime fields that make use of Toeplitz matrices to get faster field arithmetic. Then, we give parameter choice details to select prime fields that support TMVP operations and propose some prime fields to work on. We propose a new multiplication algorithm over F_{2^{255}-19} where the de-facto standard Curve25519 algorithm is based on. The proposed algorithm for the underlying finite field multiplication exploits the TMVP and achieves salient results. We also introduce the safe curve selection rationale and discuss about attacks on ECC. Next, we propose a new curve choice parameter and safe curve generation process. Finally, we introduce the Curve2663 and give details about its implementation and benchmark results and conclude the thesis.Ph.D. - Doctoral Progra

The effect of an eight week proprioception training programme on knee joint proprioception in taekwondo athletes

Background: A regular proprioception training programme leads to significant improvement in the proprioceptive ability of athletes. Research subject: The purpose of this study was to investigate the suitability of the knee joint proprioception for active taekwondo athletes and to examine the effects of an eight-week training proprioception programme on knee joint proprioception. Type of study: Randomised controlled trial. Methods: A total of 42 healthy taekwondo athletes participated in this study voluntarily. They were randomly divided into two groups: An experimental group of males (N=13) and females (N=13) undertaking a proprioception training programme and a control group of males (N=8) and females (N=8) who did not undertake the proprioception training programme during the eight-week period. The proprioception training programme was applied to the subjects three days per week for eight weeks. The measurement of the proprioception of subjects was taken using the Multi-joint System Biodex System 3 Pro isokinetic testing. Knee joint proprioception was evaluated twice: before and after the proprioception training programme. Results: After the eight-week proprioception training programme, significant differences were observed in both the dominant (differences of mean 1.76±0.41 for 30° and 2.83±1.52 for 70° in female; 1.86±0.66 for 30° and 2.96±2.4 for 70° in male) and non-dominant (differences of mean 1.99±1.4 for 30° and 2.94±1.16 for 70° in female; 1.67±0.64 for 30° and 4.44±2.89 for 70° in male) knee joint proprioception scores in the experimental group (p 0.05). Conclusion: The proprioception training programme improved knee joint proprioception based on the detection of positional sense for female and male taekwondo athletes

A Practice for Performance Determination of Small Ruminant Farms: The Case Study of Izmir Province in Turkey

Bu çalışmada, İzmir ili yöresinde küçükbaş hayvan yetiştiriciliği yapan yarı entansif yapıdaki 158 adet işletmenin, 2013 yılı itibariyle barındırmadaki yapısal olanakları ve yürüttükleri hayvancılık faaliyetlerinin geliştirilen bir performans yaklaşımıyla değerlendirilmesi amaçlanmıştır. İlk olarak, örnek işletmelerde barınakların yeterlilik düzeyini tanımlayan "yapısal performans"; öngörülen "yapı tekniği" ve "tasarım-konum" göstergesine göre hesaplanmıştır. Yürütülen hayvancılık faaliyetlerinin yeterlilik düzeyini tanımlayan "hayvancılık performansı" ise; öngörülen "yemleme" ile "yavru büyütme - sağım" göstergelerine göre belirlenmiştir. Ayrıca bu iki performansa göre örnek işletmelerin genel performansları da hesaplanmıştır. Bu hesaplamalarda toplam 35 adet temel değişken (teknik özellik/bilimsel esas) dikkate alınmıştır. Daha sonra belirlenen performans değerleri, oluşturulan dört ayrı performans sınıfına (çok iyi, iyi, orta ve kötü) göre değerlendirilmiştir. Buna göre, örnek işletmelerin yapısal (0,37), hayvancılık (0,46) ve genel (0,42) performans değerlerinin "orta" sınıfta yer aldığı, ancak hayvancılık performansının "iyi" sınıfa daha yakın olduğu anlaşılmıştır. Performans sonuçları, araştırma alanındaki küçükbaş hayvancılık işletmelerinde özellikle barınakların yapı tekniği ve tasarım yönünden iyileştirilmesi, hayvancılık faaliyetlerinde yavru büyütme ve sağım ile ilgili pratik yetiştirme uygulamalarının geliştirilmesi gerektiğini göstermiştirThe aim of this study was to evaluate the situation of farm structures and small ruminant production activities in 158 semi-intensive farms as of 2013 by a developed performance approach. Firstly, "structural performance" defining the sufficiency of the barns was calculated in sample farms according to predicted “building technique" and “design-location" indicators. “Animal husbandry performance" defining the sufficiency level in small ruminant production activities carried out, was determined based on predicted "feeding" and "rearing - milking" indicators. In addition, the overall farm performance of the sample farms was calculated according to these performances. In these calculations, total 35 major variables (technical specifications / scientific basis) were taken into consideration. Then, the determined performance levels were evaluated according to the created four different performance classes (very good, good, fair and poor).Consequently, it was understood that structural (0,37) and overall (0,42) performance values of sample farms take place in “fair" class, but animal husbandry (0,46) performance has proved to be much closer to the "good" class. Performance results showed that the requirements for improvements in small ruminant farms in the research area, especially in terms of construction techniques and designing of the barns, and also for small ruminant practices related to rearing and milkin

The effects of aerobic dance exercise on body composition changes associated with weight change in sedentary women

Arslan, Fatma (Aksaray, Yazar)The purpose of this study was to assess the effects of aerobic dance exercise on body composition in sedentary overweight women. In this study, Total 55 adult sedentary women participated as volunteers. The age, height and weight averages of the subjects exercise and control group were respectively 35,10±9,12 years, 1,60±5,22 m and 68,55±6,73 kg (n=29) and 30,27±10,85 years, 1,59±5,53 cm and 61,25±8,38 kg (n=26). Body composition (via skinfolds caliper), waist hip ratio, waist circumference were measured and body fat percentage, Basal Metabolic Rate and Lean Body Mass were calculated at sedentary women. The measurements were taken twice as before and after aerobic-dance exercise being applied an 8-week series of one hour exercise three days per week. The control group did not participate in any physical activity during the six-week period. There were significant differences between pretest and posttest for weight, body mass index, waist circumference, waist hip ratio, metabolic and body composition parameters in exercise group (p<0,05). Besides there were significantly decreased body weight, Lean Body Mass, Basal Metabolic Rate and fat percentage (p<0,05). Furthermore, there were not significant differences between pretest and posttest for waist circumference, waist hip ratio, body composition parameters, Lean Body Mass, Basal Metabolic Rate, body weight and body fat percentage in control group(p>0,05). As a result, it can be say that aerobic dance exercise at a moderate intensity and duration can improve physical fitness and can decrease body fat percentage, Lean Body Mass and Basal Metabolic Rate during weight loss...

Death Due To Gas Pressure Of Blank Firing Gun: a Case Report

Gaz tabancaları şekil, boyut ve çalışma prensipleri itibariyle gerçek modellerinden hiçbir farkı bulunmayan, ancak namluları farklı olan ateşli silahlardır. Namluda ve kullanılan fişeklerde herhangi bir değişiklik yapılmadan bu silahlarla bitişik atış mesafesinden yapılan atışlarda özellikle kafa ve boyun bölgesinde ölümcül yaralanmalar meydana gelebilmektedir. Bizim olgumuzda; yapılan dosya tetkikinde gaz tabancasının ateş alması sonucu, kişinin başından yaralandığı, kaldırıldığı hastanede dört gün sonra öldüğü radyolojik incelemede beyinde herhangi bir metalik imaj tespit edilmediği kayıtlıdır. Otopside haricen kafada sağ temporalde önde üzeri sütüre yara, iç muayenede bu bölgede 1,5X2 cm boyutlarında kemik defekti olduğu, baş açıldığında beyinde yaygın subaraknoidal kanama, kıvamda yumuşama, kontüzyon olduğu görülmüştür. Göğüs ve batın açıldığında travmatik-patolojik özellik saptanmamıştır. Ölümün kafa travmasına bağlı kafatası kırığıyla müterafık beyin kanaması, beyin doku harabiyeti sonucu meydana gelmiş olduğu, bu yaralanmanın kurusıkı olarak adlandırılan ateşli silahla husulünün mümkün olduğu kanaatine varılmıştır. Bu çalışmada genellikle zararsız görülen gaz tabancası ile yapılan bitişik atışlarda sadece gaz basıncına bağlı kafatası kemiği gibi kemik yapının bile kırılarak ölüm meydana gelebileceğini ve bu silahların satışıyla ilgili düzenleme yapılması gerektiğini vurgulamayı amaçladık.There is no difference between gas guns and the actual gun models in terms of shape, size and working principle except barrel. Fatal injuries may occur particularly in the head and neck region using adjacent firings with these guns without any barrel and bullet changes. In the present case, a head trauma associated with gas gunshot, no intracranial foreign body on radiologic examination and death four days after the hospital admission were provided from the chart review. During autopsy, a sutured wound on the right temporal head externally and a 1.5x2 cm bone defect in this region on internal examination was observed. Diffuse subarachnoid hemorrhage, softening of tissue consistency and contusions was detected in the brain when the head opened. Traumatic or pathological features were not observed when the chest and abdomen opened. It was concluded that death was related to skull fracture, brain hemorrhage and tissue injury due to head trauma which possibly caused by blank gunshot injury. In this case report, we aimed to emphasize death which may results with skull fracture due to gas pressure from adjacent firings with gas guns and new regulations should be made on the sale of the gas guns