CSM docked DAP/orbital assembly bending interaction-axial case

A digital autopilot which can provide attitude control for the entire Skylab orbital assembly using the service module reaction control jets is described. An important consideration is the potential interaction of the control system with the bending modes of the orbital assembly. Two aspects of this potential interaction were considered. The first was the possibility that bending induced rotations feeding back through the attitude sensor into the control system could produce an instability or self-sustained oscillation. The second was whether the jet activity commanded by the control system could produce excessive loads at any of the critical load points of the orbital assembly. Both aspects were studied by using analytic techniques and by running simulations on the all-digital simulator

A Complex Disease with Complex Discourse: Exploring the Online Messaging of Two Canadian Obesity Charities and the Implications for Weight Stigma

Researchers warn that sizeism and weight stigma can prevent individuals from seeking health care, increase feelings of depression, and even contribute to weight gain and the worsening of negative health behaviours (Chrisler and Barney 2017; O’Hara and Gregg 2006; Puhl and Heuer 2009; 2010; Tomiyama 2014). The motivation for this study relates to a broader social problem of weight stigma and is premised upon evidence that suggests that stigmatizing content precipitates poor perceptions of obese individuals (Frederick et al. 2020; Puhl and Heuer 2010). Drawing upon the concept of biopedagogy, this case study qualitatively analyzes the online messages produced by two prominent obesity organizations in Canada (Harwood 2009; Rail 2012). Specifically, this study asks, how do obesity organizations frame and define obesity? How does the organizational context contribute to the framing of obesity-related messages? How do these organizations reproduce or challenge weight stigma? Multiple and competing message frames were observed, reflecting different paradigms of obesity discourse. In light of Obesity Canada’s goal to end weight bias, the framing of obesity as a disease is interpreted as an attempt to resolve the individual blame attached to obesity (Ata et al. 2018; Puhl and Heuer 2010). In contrast, the Childhood Obesity Foundation emphasizes parental responsibility and lifestyle change, upholding individualistic and oversimplistic explanations of obesity (O’Hara and Gregg 2006; Salas 2015). While this study draws upon past research about obesity discourse and weight stigma, it is the first of its kind to explore the online messaging of two Canadian obesity organizations

Assessing Learning Outcomes in Middle-Division Classical Mechanics: The Colorado Classical Mechanics/Math Methods Instrument

Reliable and validated assessments of introductory physics have been instrumental in driving curricular and pedagogical reforms that lead to improved student learning. As part of an effort to systematically improve our sophomore-level Classical Mechanics and Math Methods course (CM 1) at CU Boulder, we have developed a tool to assess student learning of CM 1 concepts in the upper-division. The Colorado Classical Mechanics/Math Methods Instrument (CCMI) builds on faculty consensus learning goals and systematic observations of student difficulties. The result is a 9-question open-ended post-test that probes student learning in the first half of a two-semester classical mechanics / math methods sequence. In this paper, we describe the design and development of this instrument, its validation, and measurements made in classes at CU Boulder and elsewhere.Comment: 11 pages, 6 figures, 1 tabl

Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis

This article is available open access through the publisher’s website. Copyright @ 2009 Oxford University Press.Background - Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world. Historically, susceptibility to IA has been associated with prolonged neutropenia; however, IA has now become a major problem in patients on calcineurin inhibitors and allogenic hematopoetic stem cell transplant patients following engraftment. These observations suggest complex cellular mechanisms govern immunity to IA. Methods - To characterize the key early events that govern outcome from infection with Aspergillus fumigatus we performed a comparative immunochip microarray analysis of the pulmonary transcriptional response to IA between cyclophosphamide-treated mice and immunocompetent mice at 24 h after infection. Results - We demonstrate that death due to infection is associated with a failure to generate an incremental interferon-γ response, increased levels of interleukin-5 and interleukin-17a transcript, coordinated expression of a network of tumor necrosis factor–α-related genes, and increased levels of tumor necrosis factor–α. In contrast, clearance of infection is associated with increased expression of a number genes encoding proteins involved in innate pathogen clearance, as well as apoptosis and control of inflammation. Conclusion - This first organ-level immune response transcriptional analysis for IA has enabled us to gain new insights into the mechanisms that govern fungal immunity in the lung.The BBSRC, CGD Research Trust, and the MRC

Failure of Sterne- and Pasteur-Like Strains of Bacillus anthracis to Replicate and Survive in the Urban Bluebottle Blow Fly Calliphora vicina under Laboratory Conditions

Britta von Terzi, Peter C. B. Turnbull, Wolfgang Beyer, University of Hohenheim, Institute of Environmental and Animal Hygiene, Stuttgart, GermanySteve E. Bellan, Center for Computational Biology and Bioinformatics, University of Texas at Austin, Austin, Texas, United States of AmericaThis study aimed to elucidate the bacteriological events occurring within the gut of Calliphora vicina, selected as the European representative of blow flies held responsible for the spread of anthrax during epidemics in certain parts of the world. Green-fluorescent-protein-carrying derivatives of Bacillus anthracis were used. These lacked either one of the virulence plasmids pXO1 and pXO2 and were infected, or not infected, with a worm intestine phage (Wip4) known to influence the phenotype and survival of the pathogen. Blood meals were prepared for the flies by inoculation of sheep blood with germinated and, in case of pXO2+ strains, encapsulated cells of the four B. anthracis strains. After being fed for 4 h an initial 10 flies were externally disinfected with peracetic acid to ensure subsequent quantitation representing ingested B. anthracis only. Following neutralization, they were crushed in sterile saline. Over each of the ensuing 7 to 10 days, 10 flies were removed and processed the same way. In the absence of Wip4, strains showed steady declines to undetectable in the total B. anthracis counts, within 7–9 days. With the phage infected strains, the falls in viable counts were significantly more rapid than in their uninfected counterparts. Spores were detectable in flies for longer periods than vegetative bacteria. In line with the findings in both biting and non-biting flies of early workers our results indicate that B. anthracis does not multiply in the guts of blow flies and survival is limited to a matter of days.This work was funded by grant BE 2157/3-1 of the German Research Foundation (DFG). SEB was funded by a United States National Institute of General Medical Sciences MIDAS grant U01GM087719 to Lauren A. Meyers and Alison P. Galvani. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Center for Computational Biology and BioinformaticsEmail: [email protected]

First year student expectations: Results from a university-wide student survey

Although much has been written on the first-year experience of students at higher education institutions, less attention has been directed to the expectations of students when they enter an institution for the first time. This paper provides additional insights into the expectations of students at an Australian university and highlights areas in which students’ expectations may not necessarily align with the realities of common university practices. By providing opportunities for students to articulate their expectations, staff are able to use the responses for a constructive dialogue and work towards a more positive alignment between perceived expectations and levels of student satisfaction with their experience.Geoffrey Crisp, Edward Palmer, Deborah Turnbull, Ted Nettelbeck, Lynn Ward, Amanda LeCouteur, Aspa Sarris, Peter Strelan, and Luke Schneide