Women and Domestic violence in the professional experience of Italian General Practitioners

A number of studies have investigated the roots of the destructive power acting within the couple (Welzer Lang, 1991; Walker, 1979, 2000). Danis and Lockhart (2003) highlighted how social workers’ best practices, are not frequently used, especially in regards to contact with the victims of intimate-partner violence. We investigated how Italian general practitioners (IGPs) deal with this issue within their professional practice. A snowball sample of 268 IGPs was taken, in order to collect their beliefs concerning the victim, the aggressor and the violent couple’s relationship. Furthermore the experience in coping with both suspected and actual cases of domestic violence, as well as the GP’s needs and expectations was taken in consideration

Nuove applicazioni per le unità abitative in emergenza: tecnologie e tecniche della tradizione costruttiva andina amazonica

This work reports the result of a research activity conducted in Bolivia in the year 2020, in synergy between Bolivian Polytechnic University School "Josè Maria Nunez del Prado", University of Naples Federico II and Pegaso Telematic University. In particular, the research had as its object the study of a housing unit suitable for coping with the floods that frequently afflict some Bolivian peasant populations. During the research, much attention was initially paid to the historical, political, socio-economic aspects and to the cultural and traditional characteristics of the ethnic groups that make up the population of Bolivia; subsequently, the morphology and hydrography of the Bolivian territory were examined, as well as the climate, the trend of rainfall and the El Niño and La Niña phenomena that often cause floods with serious risks for the populations, especially rural ones. Having completed these first two phases of the research, the authors moved on to the study of the traditional construction characteristics of rural architecture, paying particular attention to the basic construction materials used in the peasant areas of Bolivia, in particular to raw earth and bamboo, as well as the principles and rules that regulate the construction of rural housing in Bolivia. For rural architecture, the traditional Pawichi house and the traditional dwellings of the indigenous Chiquitana population were examined in detail. Only after having acquired all these important aspects, the research became interested in the design of a new rural house which, respecting Bolivian cultural traditions, would be able to cope with floods and reduce the risks associated with them. In the design of this new emergency housing unit, the authors focused their attention not only on the compositional and functional aspects of the housing unit, but also on the constructive aspects by designing new structural elements such as the pillars made with five bamboo canes suitably linked together. with knots of the Andean construction tradition. The composition of the housing unit proposed by the authors is governed by a basic 4x4 module that can be full, or delimited by infill and window frames, or empty, or without surrounding infill elements to allow the creation of the traditional place for socialization, the Punilla. Never as in this case have, I been particularly happy with the invitation formulated by the authors, and in particular by the young researchers, Francesca Volpe and Emanuele La Mantia, to present their work. In fact, I was able to see the procedural quality of the research and the intelligent design procedure that led to the definition of a housing prototype of great interest for the Andean populations

Partial purification and MALDI-TOF MS analysis of UN1, a tumor antigen membrane glycoprotein.

UN1 is a membrane glycoprotein that is expressed in immature human thymocytes, a subpopulation of peripheral T lymphocytes, the HPB acute lymphoblastic leukemia (ALL) T-cell line and fetal thymus. We previously reported the isolation of a monoclonal antibody (UN1 mAb) recognizing the UN1 protein that was classified as "unclustered" at the 5th and 6th International Workshop and Conference on Human Leukocyte Differentiation Antigens. UN1 was highly expressed in breast cancer tissues and was undetected in non-proliferative lesions and in normal breast tissues, indicating a role for UN1 in the development of a tumorigenic phenotype of breast cancer cells. In this study, we report a partial purification of the UN1 protein from HPB-ALL T cells by anion-exchange chromatography followed by immunoprecipitation with the UN1 mAb and MALDI-TOF MS analysis. This analysis should assist in identifying the amino acid sequence of UN

From risk-based health surveillance to health promotion: an evidence-based experience in a health care setting.

Health surveillance’s aim consists in different aspects: (i) to ensure worker’s health, (ii) to comply regulation, (iii) to detect health changes at their onset, (iv) to reduce cost, (v) to provide a fitness for job judgement, (vi) to provide a medical baseline and (vii) to be part of a preventive programme. Some of these aspects are perceived as benefits from the different stakeholders. Employers indicated as benefits worker’s satisfaction improvement, cost reduction, relationship improvement, early detection of health changes5. The study showed some other benefits: an improvement in worker’s satisfaction, an improvement in the relationship between stakeholders (even though based on qualitative data only), an early detection of health changes in few cases and a sickness absence reduction after influenza vaccination programme

2D continuous spectrum of shear Alfven waves in the presence of a magnetic island

The radial structure of the continuous spectrum of shear Alfven modes is calculated in the presence of a magnetic island in tokamak plasmas. Modes with the same helicity of the magnetic island are considered in a slab model approximation. In this framework, with an appropriate rotation of the coordinates the problem reduces to 2 dimensions. Geometrical effects due to the shape of the flux surface's cross section are retained to all orders. On the other hand, we keep only curvature effects responsible of the beta induced gap in the low-frequency part of the continuous spectrum. New continuum accumulation points are found at the O-point of the magnetic island. The beta-induced Alfven Eigenmodes (BAE) continuum accumulation point is found to be positioned at the separatrix flux surface. The most remarkable result is the nonlinear modification of the BAE continuum accumulation point frequency

A rare case of cerebral venous thrombosis and disseminated intravascular coagulation temporally associated to the covid-19 vaccine administration

Globally, at the time of writing (20 March 2021), 121.759.109 confirmed COVID-19 cases have been reported to the WHO, including 2.690.731 deaths. Globally, on 18 March 2021, a total of 364.184.603 vaccine doses have been administered. In Italy, 3.306.711 confirmed COVID-19 cases with 103.855 deaths have been reported to WHO. In Italy, on 9 March 2021, a total of 6.634.450 vaccine doses have been administered. On 15 March 2021, Italian Medicines Agency (AIFA) decided to temporarily suspend the use of the AstraZeneca COVID-19 vaccine throughout the country as a precaution, pending the rulings of the European Medicines Agency (EMA). This decision was taken in line with similar measures adopted by other European countries due to the death of vaccinated people. On 18 March 2021, EMA’s safety committee concluded its preliminary review about thromboembolic events in people vaccinated with COVID-19 Vaccine AstraZeneca at its extraordinary meeting, confirming the benefits of the vaccine continue to outweigh the risk of side effects, however, the vaccine may be associated with very rare cases of blood clots associated with thrombocytopenia, i.e., low levels of blood platelets with or without bleeding, including rare cases of cerebral venous thrombosis (CVT). We report the case of a 54-year-old woman who developed disseminated intravascular coagulation (DIC) with multi-district thrombosis 12 days after the AstraZeneca COVID-19 vaccine administration. A brain computed tomography (CT) scan showed multiple subacute intra-axial hemorrhages in atypical locations, including the right frontal and the temporal lobes. A plain old balloon angioplasty (POBA) of the right coronary artery was performed, without stent implantation, with restoration of distal flow, but with persistence of extensive thrombosis of the vessel. A successive thorax angio-CT added the findings of multiple contrast filling defects with multi-vessel involvement: at the level of the left upper lobe segmental branches, of left interlobar artery, of the right middle lobe segmental branches and of the right interlobar artery. A brain magnetic resonance imaging (MRI) in the same day showed the presence of an acute basilar thrombosis associated with the superior sagittal sinus thrombosis. An abdomen angio-CT showed filling defects at the level of left portal branch and at the level of right suprahepatic vein. Bilaterally, it was adrenal hemorrhage and blood in the pelvis. An evaluation of coagulation factors did not show genetic alterations so as the nasopharyngeal swab ruled out a COVID-19 infection. The patient died after 5 days of hospitalization in intensive care

tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1.

Recent studies suggest a close relationship between cell metabolism and apoptosis. We have evaluated changes in lipid metabolism on permeabilized hepatocytes treated with truncated Bid (tBid) in the presence of caspase inhibitors and exogenous cytochrome c. The measurement of b-oxidation flux by labeled palmitate demonstrates that tBid inhibits b-oxidation, thereby resulting in the accumulation of palmitoyl-coenzyme A (CoA) and depletion of acetyl-carnitine and acylcarnitines, which is pathognomonic for inhibition of carnitine palmitoyltransferase-1 (CPT-1). We also show that tBid decreases CPT-1 activity by a mechanism independent of both malonyl-CoA, the key inhibitory molecule of CPT-1, and Bak and/or Bax, but dependent on cardiolipin decrease. Overexpression of Bcl-2, which is able to interact with CPT-1, counteracts the effects exerted by tBid on b-oxidation. The unexpected role of tBid in the regulation of lipid b-oxidation suggests a model in which tBid-induced metabolic decline leads to the accumulation of toxic lipid metabolites such as palmitoyl-CoA, which might become participants in the apoptotic pathway

The bisphenol a induced oxidative stress in non-alcoholic fatty liver disease male patients: A clinical strategy to antagonize the progression of the disease

Introduction: Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 μg of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods: We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at baseline clinical, biochemical, and food consumption assessments as well as the evaluation of physical exercise, thiobarbituric acid reactive substances (TBARS), plasmatic and urinary BPA and estrogen levels. The results obtained were compared with those of healthy control subjects and, in the NAFLD group, between baseline and the end of treatment. Results: A direct proportionality between TBARS levels and BPA exposure was shown (p < 0.0001). The therapy determined a reduction of TBARS levels (p = 0.011), an improvement of alanine aminotransferase, aspartate aminotransferase, insulinemia, homeostatic model assessment insulin resistance, C reactive protein, tumor necrosis factor alpha (p < 0.05), an increase of conjugated BPA urine amount, and a reduction of its free form (p < 0.0001; p = 0.0002). Moreover, the therapy caused an increase of plasmatic levels of the native form of estrogens (p = 0.03). Conclusions: We highlighted the potential role of BPA in estrogen oxidation and oxidative stress in NAFLD patients. The use of Realsil 100D could contribute to fast BPA detoxification and to improve cellular antioxidant power, defending the integrity of biological estrogen-dependent pathways