41 research outputs found

    Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort

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    The objective was to examine whether: (1) statin use was associated with muscle related outcomes at age 60–64, (2) these associations were modifed by 25-hydroxyvitamin D (25(OH)D) status and explained by infammation, body-size or lifestyle in a British birth cohort. Markers of myalgia (intrusive body pain) and myopathy (self-reported and performance-based measures) were examined in 734 men and 822 women (MRC National Survey of Health and Development). Statin use was associated with intrusive body pain, difculty climbing stairs and slower chair rise speed. Some associations were modifed by 25(OH)D e.g. the association with intrusive body pain was evident in the insufcient (13–20ng/l) and defcient(20ng/l (OR=0.8,95% CI 0.5–1.4) (p=0.003 for interaction). Associations were maintained in fully adjusted models of intrusive body pain and difculty climbing stairs, but for chair rise speed they were fully accounted for by infammation, body-size and lifestyle. In a nationally representative British population in early old age, statin use was associated with lower limb muscle-related outcomes, and some were only apparent in those with 25(OH)D status below 20ng/l. Given 25(OH)D is modifable in clinical practice, future studies should consider the links between 25(OH)D status and muscle related outcomes

    Unilateral bronchospasm after interpleural analgesia with bupivacaine [2]

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    10.1111/j.1399-6576.2005.00872.xActa Anaesthesiologica Scandinavica50451

    Priapism and general anaesthesia

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    Pharmacognostical standardization and HPTLC fingerprinting analysis of <em>Crocus sativus</em> L.

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    592-597Crocus is one of the highest priced plant materials on the earth and due to its high cost; it is frequently subjected to adulteration of various types. Owing to the importance of this precious commodity, present study on pharmacognostical analysis and chemical fingerprinting of Crocus sativus L. was undertaken. The stigmas of the plant were collected from two different geographical locations of the Himalayan regions having different ecological, climatic and geographical surroundings and evaluated for their specific characteristics. These samples were designated as sample S-1 and S-2. The organoleptic evaluation revealed a specific dark orange brown colour, characteristic odour and bitter taste of both the samples. Powder drug analysis of samples showed the presence of specific cellular structures, viz. abundant oil globules, helical to spiral xylem vessels, pollen grains, fiber and epidermal cells of style showing papillae structures. The preliminary phytochemical screening of samples revealed that sample S-1 was superior in terms of phytochemicals than the sample S-2. These samples were further evaluated by detailed chemical fingerprinting using HPTLC. Chemical fingerprinting showed the presence of 11 and 8 peaks in S-1 and S-2, respectively corresponding to the different phytochemicals and some peaks resembles the main constituents saffranol and crocin in both the samples. The pharmacognostic, physiochemical and phytochemical parameters evaluated in this study would be useful for identification of this highly prized and commonly adulterated plant used in various pharmaceutical and food preparations

    Letters to the Editor

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