Optic Neuritis Associated with Anti-Myelin-Oligodendrocyte Glycoprotein Antibodies: a Case Series

Optic neuritis associated with antibodies against myelin-oligodendrocyte glycoprotein (MOG) is a sight threatened disease recently identified. The goal of this study was to describe the clinical features, the MRI findings and the response to steroid therapies in a series of patients suffering from an optic neuritis associated with MOG antibodies

Etude rétrospective observationnelle de 71 cas d'oedèmes papillaires pris en charge au CHU de Bordeaux

BUT DE L'ETUDE : Décrire les caractéristiques sociodémographiques, cliniques et paracliniques des patients ayant un œdème papillaire (OP) unilatéral ou bilatéral consultant aux urgences ophtalmologiques. MATERIELS ET METHODES : Il s'agit d'une étude rétrospective observationnelle des patients avec un OP, consultant aux urgences du centre hospitalo-universitaire de Bordeaux, entre le 1er octobre 2008 et le 31 octobre 2009. L'inclusion des patients a été prospective. Le recueil des données s'est fait par retour au dossier médical du patient. RESULTATS : Nous avons inclus 71 patients (90 yeux) dont 52 avaient un OP unilatéral et 19 avaient un OP bilatéral. 66 % des patients (n = 47) étaient adressés par leur ophtalmologiste aux urgences pour la prise en charge d'un OP. Parmi les 52 patients avec un OP unilatéral, on comptait 61,5 % de femmes (n = 32) et 38,5 % d'hommes (n = 20). La moyenne d'âge était de 53,5 ans (ơ = 22,9 ans), avec un âge plus élevé pour les hommes que pour les femmes (61,1 ans vs 48,7 ans avec p = 0,0565). Le diagnostic retenu était une neuropathie optique ischémique antérieure aigue (NOIAA) pour 27 patients, une neuropathie optique inflammatoire (NOI) pour 17 patients et une hypertension intracrânienne (HTIC) pour 3 patients. Parmi les 19 patients avec un OP bilatéral, on comptait 74 % de femmes (n = 14) et 26 % d'hommes (n = 5). La moyenne d'âge était de 36,4 ans (ơ = 20,2 ans), avec un âge plus élevé pour les hommes que pour les femmes (50,6 ans vs 31,3 ans avec p = 0,0649). Le diagnostic retenu était une HTIC pour 8 patients, une NOI pour 5 patients et une NOIAA pour 4 patients. CONCLUSION : Cette étude aura permis d'évaluer notre prise en charge des patients avec OP consultant aux urgences ophtalmologiques. Le diagnostic étiologique d'OP, parfois complexe, repose sur les données cliniques et paracliniques.BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF

Swept Source OCT Angiography Quantification in Optic Nerve Edema: Preliminary Results

OCT angiography (OCT-A) is a new imaging tool allowing the visualization of the superficial optic disc vessels and the superficial and deep peripapillary vascular network without any intra-venous dye injection. The morphological features of OCT-A in optic disc edema (papilledema, ischemic and inflammatory) have already been described. With the last development of Swept Source OCT-A software, it is possible to measure the peripapillary vessel density and the vascular flux. The aim of this study is to evaluate the relevance of these metrics in the diagnosis of optic disc edema

p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.: P38 CONTROLS THE MESODERMAL COMMITMENT OF ES CELLS

International audienceEmbryonic stem (ES) cells differentiate in vitro into all cell lineages. We previously found that the p38 mitogen activated kinase (p38MAPK) pathway controls the commitment of ES cells toward either cardiomyogenesis (p38 on) or neurogenesis (p38 off ). In this study, we show that p38α knock-out ES cells do not differentiate into cardiac, endothelial, smooth muscle, and skeletal muscle lineages. Reexpression of p38MAPK in these cells partially rescues their mesodermal differentiation defects and corrects the high level of spontaneous neurogenesis of knock-out cells. Wild-type ES cells were treated with a p38MAPK-specific inhibitor during the differentiation process. These experiments allowed us to identify 2 early independent successive p38MAPK functions in the formation of mesodermal lineages. Further, the first one correlates with the regulation of the expression of Brachyury, an essential mesodermal-specific transcription factor, by p38MAPK. In conclusion, by genetic and biochemical approaches, we demonstrate that p38MAPK activity is essential for the commitment of ES cell into cardiac, endothelial, smooth muscle, and skeletal muscle mesodermal lineages

OCT Angiography Quantification of the Capillary Peripapillary Plexus in Non-Arteritic Anterior Ischemic Neuropathy

OCT angiography is an imaging method allowing the visualization of the retinal peripapillary and optic nerve head (ONH) vessels. With specific algorithms it is also possible to quantify the vascular density and the flux index of these areas. Quantification Is based on an automatic segmentation which includes both RNFL and GCL layers, each of them being vascularized by two different plexus. At the acute phase of non-arteritic anterior ischemic optic neuropathies (NAION) previous studies have shown controversial results concerning the peripapillary blood flow and vessel density. The aim of our study is to perform a vascular quantification of the top-most retinal layer including exclusively the RNFL using a new algorithm

Accurate Identification and Quantification of DNA Species by Next Generation Sequencing in Adeno-Associated Viral Vectors Produced in Insect Cells

Accurate Identification and Quantification of DNA Species by Next Generation Sequencing in Adeno-Associated Viral Vectors Produced in Insect Cells. 20. Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT

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