Effect of physical activity program applied to patients with Alzheimer's disease on cognitive functions and depression level: a randomised controlled study

PubMed ID 37487556Background: In this study, it was aimed to evaluate the effect of a physical activity program applied to Alzheimer's disease patients on cognitive functions and depression. Method: This study is a randomised controlled study designed in a pre-test post-test design. It was conducted with 72 patients in total, 36 of whom were interventions and 36 were controls, at the Alzheimer's Day Life Centre. In data collection, a personal information form prepared by the researchers, questioning the socio-demographic characteristics of individuals, Mini Mental Test and Cornell Dementia Depression Scale were used. In the analysis of the data, the homogeneity between the groups in terms of independent variables was evaluated by performing a Chi-square analysis. In the evaluation of cognitive functions and depression levels of the experimental and control groups, t-test was used in the dependent and independent groups. Statistical significance level was accepted as P < 0.05. Results: In the study, the cognitive functions of the experimental group, in which a 12-week physical activity program was applied, were higher than the control group and the difference was significant (P < 0.05). Similarly, the depression scale mean score of the experimental group was found to be better than the depression level of the individuals in the control group, and the difference was significant (P < 0.05). Conclusion: The 12-week physical activity program applied to Alzheimer's disease patients improved cognitive functions and depression levels of individuals

Miyokardiyal İskemi Oluşturan ve Sol Ventrikülografiyi Taklit Eden Kalıcı Tebesian Venlerin Ciddi Formu

Koroner arter fistülü nadir bir konjenital anomalidir. Hastaların çoğu asemptomatik olmakla birlikte bazı hastalar semptomatik olabilmekte ve miyokardiyal iskemi, tromboz ve emboli, kalp yetmezliği ve aritmilerle gelebilmektedir. yazımızda efor dispnesi ve anginası bulunan ve miyokard perfüzyon sintigrafisinde geri dönüşlü inferior ve apikal defekt satanan 70 yaşında erkek sunulmuştur. Koroner anjiografide koroner darlık saptanmadı ancak sol ön inen arter, sirkümfleks arter ve sağ koroner arterden çoklu mikrofistüller aracılığıyla sol ventriküler kaviteye boşalan ve sol ventrikülografi görüntüsü oluşturan kapiller boyanma izlendi. Küçük mikrofistüllerden dolayı hastaya medikal tedavi verildi, beta bloker, aspirin ve ranolazin tedavisi ile taburcu edildi. Bir ay sonraki kontrolde hasta yakınmalarında azalma olduğunu belirtti

Cardiovascular risk unawareness is common in individuals admitting to cardiology outpatient clinics in Turkey: the CVSCORE-TR study

Zoghi, Mehdi/0000-0002-8156-2675; Kis, Mehmet/0000-0003-0775-8992WOS: 000573998900001PubMed: 32998573Objectives Cardiovascular "risk" is an abstract concept that is frequently misunderstood by the general public. However, correct estimation of one's own cardiovascular risk is important as risk unawareness is associated with noncompliance with interventions aimed to reduce risk burden. Knowing the prevalence and factors linked with an increased probability of risk unawareness are therefore important to develop strategies aimed to increase risk awareness.Aims.To study prevalence of risk unawareness and to understand risk markers associated with risk underestimation and overestimation.Design.A total of 1716 participants were enrolled to the study in 33 centers across Turkey. Relevant demographic and clinical data were collected by direct interview. Cardiovascular risk of the participants was calculated using SCORE risk charts.Results.Ten-year risk for a fatal cardiovascular event was calculated as low in 633 (36.8%), intermediate in 513 (29.9%) and high-very high in 570 (33.2%) participants, respectively. According to these findings, 34.6% (n = 593) of the participants estimated their risk correctly, whereas 22.7% (n = 390) of the participants overestimated and 42.7% (n = 733) of the participants underestimated their risk. Male gender was the sole factor that was associated with an increased risk of underestimation, while having hypertension, significant valve disease or atrial fibrillation was associated with increased odds for risk overestimation.Conclusions.Only one-thirds of the sample was aware of their calculated risk for cardiovascular mortality and risk underestimation was the most common mode of risk unawareness, prompting concerns on the possible impact of the latter on adherence to the strategies aimed to reduce cardiovascular risk

Polikistik over sendromlu kadınlarda serum omentin, osteoprotegerin ve malondialdehit düzeylerinin değerlendirilmesi: prospektif vaka kontrol çalışması

Purpose: The aim of this study was to evaluate the serum levels of omentin, osteoprotegerin and malondialdehyde levels in patients with polycystic ovary syndrome (PCOS).Material and Methods: This prospective case-control study included 31 patients with the diagnosis of PCOS and 33 healthy cases as a control group. Both groups were compared according to demographic characteristics, antropometric measurements, levels of biochemical parameters and serum levels of omentin, osteoprotegerin and malondialdehyde.Results: When compared with control group, patients in PCOS group were found to have statistically significantly lower age but have higher hirsutism score, fasting glucose level, total testosteron level, free androgen index, LH level and LH/FSH ratio. There was no statistically significant difference among PCOS and control groups in terms of serum omentin, osteoprotegerin and malondialdehyde levels.Conclusion: No significant change was shown in the levels of serum omentin, osteoprotegerin and malondealdeheyde levels in women with PCOS

Usefulness of novel Martin/Hopkins and Sampson equations over Friedewald equation in cardiology outpatients: A CVSCORE-TR substudy

Background and aims The Friedewald equation (LDL-Cf) is known to produce inaccurate estimations of low-density lipoprotein cholesterol (LDL-C) when triglycerides are high (>400 mg/dL) or LDL-C is low (<70 mg/dL). The Martin/Hopkins (LDL-Cmh) and Sampson (LDL-Cs) equations were developed to overcome these limitations, but few data are available to assess whether these equations offer incremental usefulness over LDL-Cf. Our aim was to understand whether there was any incremental usefulness of novel equations on decisions regarding patient management. Methods Four thousand one hundred and ninety-six cardiology patients who were included in a multicentre registry database were analysed. Each patient was assigned to a cardiovascular risk class using the SCORE (Systematic COronary Risk Evaluation) algorithm, and relevant European guidelines were used to assess LDL-C targets. Results Compared with LDL-Cmh and LDL-Cs, LDL-Cf was able to correctly identify 96.9%-98.08% of patients as within or outside the LDL-C target, respectively, and 1.95%-2.8% of patients were falsely identified as being within the LDL-C target. Kappa coefficients for agreement between LDL-Cf vs LDL-Cmh and LDL-Cf vs LDL-Cs were 0.868 and 0.918 (P < .001). For patients not on cholesterol-lowering drugs, the decision to initiate treatment would be different in 1.2%-1.8% of cases if LDL-Cs or LDL-Cmh were used, respectively. For those already on cholesterol-lowering drugs, decisions regarding treatment intensification would be different in 1.5%-2.4% of cases if LDL-Cs or LDL-Cmh were used. Conclusions In most cardiology outpatients, the Friedewald equation has excellent agreement with the novel Martin/Hopkins and Sampson equations, and treatment decisions should not change in most patients.WOS:0006198089000012-s2.0-85101298699PubMed: 3357083

Evaluation of serum omentin, osteoprotegerin and malondialdehyde levels in women with polycystic ovary syndrome: a prospective case-control study

Purpose: The aim of this study was to evaluate the serum levels of omentin, osteoprotegerin and malondialdehyde levels in patients with polycystic ovary syndrome (PCOS). Material and Methods: This prospective case-control study included 31 patients with the diagnosis of PCOS and 33 healthy cases as a control group. Both groups were compared according to demographic characteristics, antropometric measurements, levels of biochemical parameters and serum levels of omentin, osteoprotegerin and malondialdehyde. Results: When compared with control group, patients in PCOS group were found to have statistically significantly lower age but have higher hirsutism score, fasting glucose level, total testosteron level, free androgen index, LH level and LH/FSH ratio. There was no statistically significant difference among PCOS and control groups in terms of serum omentin, osteoprotegerin and malondialdehyde levels. Conclusion: No significant change was shown in the levels of serum omentin, osteoprotegerin and malondealdeheyde levels in women with PCOS. [Cukurova Med J 2016; 41(1.000): 1-7