The Biology of Varicella-Zoster Virus Replication in the Skin

The replication of varicella-zoster virus (VZV) in skin is critical to its pathogenesis and spread. Primary infection causes chickenpox, which is characterised by centrally distributed skin blistering lesions that are rich in infectious virus. Cell-free virus in the cutaneous blistering lesions not only spreads to cause further cases, but infects sensory nerve endings, leading to the establishment of lifelong latency in sensory and autonomic ganglia. The reactivation of virus to cause herpes zoster is again characterised by localised painful skin blistering rash containing infectious virus. The development of in vitro and in vivo models of VZV skin replication has revealed aspects of VZV replication and pathogenesis in this important target organ and improved our understanding of the vaccine strain vOKa attenuation. In this review, we outline the current knowledge on VZV interaction with host signalling pathways, the viral association with proteins associated with epidermal terminal differentiation, and how these interconnect with the VZV life cycle to facilitate viral replication and shedding

Construction of MV - and SMV - optimum designs for binary response models.

Recently, Dette and Sahm (1998) have put forward a procedure to construct MV-and SMV-optimurn designs for binary response models. In order to implement computationally this procedure some assumptions have to be made and some theoretical results must be proved. This paper provides the background to produce a computer code for computing local designs for different regions of the parameters of the model. Designs for some models used in practice are also provided as well as the efficiencies for estima the parameters

O-MOORE-NICE!: new methodologies and algorithms for design and simulation of analog integrated circuits

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High-J CO line emission from young stellar objects: from ISO to FIRST

we present the CO pure rotational spectrum at high J (Jup14) obtained with the Long Wavelength Spectrometer (LWS) on board of the ISO satellite towards molecular outflows exciting sources in nearby star formation regions. The physical conditions, derived using an LVG model for the line emission, indicate the presence of warm and dense gas, probably shock excited. The model fits show that often the bulk of this CO emission is expected in the spectral range that will be covered by FIRST, indicating the potentiality of this satellite to trace the warm component of gas emission in young stellar objects

ISO-LWS grating spectroscopy: the case of R CrA star forming region

We present the far infrared spectra of the R CrA star forming region obtained with ISO-LWS. We collected a pointed observation on the Herbig Ae star R CrA and a raster scan covering the surrounding region, where HH100 (with its exciting source) and the pre-Main Sequence star T CrA are located. The OI 63μm and the CII 158μm lines have been detected in all the pointed positions, with a ratio consistent with PDR excitation. CO rotational lines (between Jup=14 and Jup=19) are detected on R CrA; from their intensities we derived, using a LVG model, the density and temperature of the emitting region. Other molecular transitions (OH and H2O) have been detected on the investigated objects; the derived cooling of all the molecular species is in agreement with C-shock as the likely excitation mechanism. The continuum emission of R CrA peaks around 100μm (as expected for a Herbig star) while the other sources (T CrA, HH100) show increasing continua up to ~200μm, indicating that they are probably less evolved sources

Understanding the role of semiochemicals on the reproductive behaviour of cheetahs (Acinonyx jubatus)—A review

The cheetah species (Acinonyx jubatus) is currently listed as vulnerable according to the International Union for Conservation of Nature (IUCN). Captive breeding has long since been used as a method of conservation of the species, with the aim to produce a healthy, strong population of cheetahs with an increased genetic variety when compared to their wild counterparts. This would then increase the likelihood of survivability once released into protected areas. Unfortunately, breeding females have been reported to be difficult due to the age of these animals. Older females are less fertile, have more difficult parturition, and are susceptible to asymmetric reproductive aging whereas younger females tend to show a significantly lower frequency of mating behaviour than that of older females, which negatively affects breeding introductions, and therefore mating. Nonetheless, the experience from breeding methods used in some breeding centres in South Africa and the Netherlands, which also rely on the role that semiochemicals play in breeding, proves that cheetahs can be bred successfully in captivity. This review aims to give the reader an in-depth overview of cheetahs’ reproductive physiology and behaviour, focusing on the role that pheromones play in this species. Furthermore, it aims to provide new insight into the use of semiochemicals to improve conservation strategies through captive breeding

Effects of dual renin-angiotensin system blockade on proteinuria in a hypertensive black African HIV infected patient

Kidney diseases manifesting as proteinuria or elevated creatinine are increasingly prevalent complications of HIV infection. We report the effects of dual renin-angiotensin system blockade on proteinuria in a hypertensive black African HIV-infected patient

ISO-LWS study of pre-main sequence sources

We present the results obtained with the ISO Long Wavelength Spectrometer on a sample of Pre-MS sources, where several molecular lines of CO, H2O and OH have been detected. The analysis of the CO lines indicates that gas temperatures as low as 200 K are consistent with the data. This would be in agreement with the relatively low abundance of water in the gas phase measured in most of the objects