Functional identity of receptors for proteolysis-inducing factor on human and murine skeletal muscle

Background: Cachexia in both mice and humans is associated with tumour production of a sulphated glycoprotein called proteolysis-inducing factor (PIF). In mice PIF binds with high affinity to a surface receptor in skeletal muscle, but little is known about the human receptor. This study compares the human PIF receptor with the murine. Methods: Human PIF was isolated from the G361 melanoma and murine PIF from the MAC16 colon adenocarcinoma. The human PIF receptor was isolated from human skeletal muscle myotubes. Protein synthesis and degradation induced by human and murine PIF was studied in human and murine skeletal muscle myotubes. Results: Both the human and murine PIF receptors showed the same immunoreactivity and Mr 40 000. Both murine and human PIF inhibited total protein synthesis and stimulated protein degradation in human and murine myotubes to about the same extent, and this was attenuated by a rabbit polyclonal antibody to the murine PIF receptor, but not by a non-specific rabbit antibody. Both murine and human PIF increased the activity of the ubiquitin-proteasome pathway in both human and murine myotubes, as evidenced by an increased 'chymotrypsin-like' enzyme activity, protein expression of the 20S and 19S proteasome subunits, and increased expression of the ubiquitin ligases MuRF1 and MAFbx, and this was also attenuated by the anti-mouse PIF receptor antibody. Conclusions: These results suggest that the murine and human PIF receptors are identical

Quasi-static and propagating modes in three-dimensional THz circuits

We provide an analysis of the electromagnetic modes of three-dimensional metamaterial resonators in the THz frequency range. The fundamental resonance of the structures is fully described by an analytical circuit model, which not only reproduces the resonant frequencies but also the coupling of the metamaterial with an incident THz radiation. We also demonstrate the contribution of the propagation effects, and show how they can be reduced by design. In the optimized design, the electric field energy is lumped into ultra-subwavelength (λ/100) capacitors, where we insert a semiconductor absorber based on the collective electronic excitation in a two dimensional electron gas. The optimized electric field confinement is exhibited by the observation of the ultra-strong light-matter coupling regime, and opens many possible applications for these structures in detectors, modulators and sources of THz radiation

Antenna-Coupled Microcavity Enhanced THz Photodetectors

Plasmonic THz photodetectors have been realized in this work, by implementing the active region of a 5 THz quantum well detector with an antenna-coupled microcavity array. Our results demonstrate a clear improvement in responsivity, polarization insensitivity and background limited performance

Deep Impression: Audiovisual Deep Residual Networks for Multimodal Apparent Personality Trait Recognition

Here, we develop an audiovisual deep residual network for multimodal apparent personality trait recognition. The network is trained end-to-end for predicting the Big Five personality traits of people from their videos. That is, the network does not require any feature engineering or visual analysis such as face detection, face landmark alignment or facial expression recognition. Recently, the network won the third place in the ChaLearn First Impressions Challenge with a test accuracy of 0.9109

Ultra-Strong Light-Matter Coupling in Deeply Subwavelength THz LC Resonators

International audienceThe ultra-strong light-matter coupling regime has been demonstrated in a novel three-dimensional inductor-capacitor (LC) circuit resonator, embedding a semiconductor two-dimensional electron gas in the capacitive part. The fundamental resonance of the LC circuit interacts with the intersubband plasmon excitation of the electron gas at ω c = 3.3 THz with a normalized coupling strength 2Ω R /ω c = 0.27. Light matter interaction is driven by the quasi-static electric field in the capacitors, and takes place in a highly subwavelength effective volume V eff = 10 −6 λ 3 0. This enables the observation of the ultra-strong light-matter coupling with 2.4 × 10 3 electrons only. Notably, our fabrication protocol can be applied to the integration of a semiconductor region into arbitrary nano-engineered three dimensional meta-atoms. This circuit architecture can be considered the building block of metamaterials for ultra-low dark current detectors

Mixing Properties of Room Temperature Patch‐Antenna Receivers in a Mid‐Infrared (λ ≈ 9 µm) Heterodyne System

A room‐temperature mid‐infrared (λ = 9 µm) heterodyne system based on high‐performance unipolar optoelectronic devices is presented. The local oscillator (LO) is a quantum cascade laser (QCL), while the receiver is an antenna coupled quantum well infrared photodetector optimized to operate in a microcavity configuration. Measurements of the saturation intensity show that these receivers have a linear response up to very high optical power, an essential feature for heterodyne detection. By providing an accurate passive stabilization of the LO, the heterodyne system reaches at room temperature the record value of noise equivalent power (NEP) of 30 pW at 9 µm and in the GHz frequency range. Finally, it is demonstrated that the injection of microwave signal into the receivers shifts the heterodyne beating over the large bandwidth of the devices. This mixing property is a unique valuable function of these devices for signal treatment in compact QCL‐based systems

Monolithic Patch-Antenna THz Lasers with Extremely Low Beam Divergence and Polarization Control

Arrays of patch antennas have impacted modern telecommunications in the RF range significantly, owing to their versatility in tailoring the properties of the emitted radiation such as beam width and polarization, along with their ease of fabrication. At higher frequencies, in the terahertz (THz) range, there is a pressing need for a similar monolithic platform to realize and enable the advanced functionalities available in the RF technology. This platform would benefit a wide variety of fields such as astronomy, spectroscopy, wireless communications, and imaging. Here, we demonstrate THz lasers made of arrays of 10 × 10 patch antenna microcavities that provide up to 25 mW output power with robust single mode frequency and spatial mode. This device architecture leads to an unprecedented beam divergence, better than 2° × 2°, which depends only on the number of resonators. This allows to functionalize the device while preserving a high quality far-field pattern. By interconnecting the symmetric square microcavities with narrow plasmonic wires along one direction, we introduce an asymmetry into the originally degenerate and cross-polarized TM01 and TM10 modes, leading to a precise control of the resonant frequency detuning between the TM modes. This feature allows devices to be designed that radiate with any coherent polarization states from linear to circular. Large-scale full-wave simulations of the emission from entire arrays support our experimental results. Our platform provides a solution to finally achieve monolithic terahertz emitters with advanced integrated functionalities such as active beam steering and polarization control

Patch Antenna Microcavities THz Quantum Cascade Lasers

We study the emission of THz quantum cascade lasers (QCLs) designed in arrays of Patch Antenna Microcavities (PAM). The array geometry is an effective strategy to control the losses and to achieve phase locking, allowing for beam shaping and high photon outcoupling efficiency. We demonstrate a 40-fold enhanced emission compared to standard ridge waveguides and a gaussian beam divergence as low as 2° x 2°

Absorption Engineering in an Ultrasubwavelength Quantum System

Many photonic and plasmonic structures have been proposed to achieve ultrasubwavelength light confinement across the electromagnetic spectrum. Notwithstanding this effort, however, the efficient funneling of external radiation into nanoscale volumes remains problematic. Here, we demonstrate a photonic concept that fulfills the seemingly incompatible requirements for both strong electromagnetic confinement and impedance matching to free space. Our architecture consists of antenna-coupled meta-atom resonators that funnel up to 90% of the incident radiation into an ultrasubwavelength semiconductor quantum well absorber of volume V = λ310–6. A significant fraction of the coupled electromagnetic energy is used to excite the electronic transitions in the quantum well, with a photon absorption efficiency 550 times larger than the intrinsic value of the electronic dipole. This system opens important perspectives for ultralow dark current quantum detectors and for the study of light–matter interaction in the extreme regimes of electronic and photonic confinement