Measurements and computational analysis of heat transfer and flow in a simulated turbine blade internal cooling passage

Visual and quantitative information was obtained on heat transfer and flow in a branched-duct test section that had several significant features of an internal cooling passage of a turbine blade. The objective of this study was to generate a set of experimental data that could be used to validate computer codes for internal cooling systems. Surface heat transfer coefficients and entrance flow conditions were measured at entrance Reynolds numbers of 45,000, 335,000, and 726,000. The heat transfer data were obtained using an Inconel heater sheet attached to the surface and coated with liquid crystals. Visual and quantitative flow field results using particle image velocimetry were also obtained for a plane at mid channel height for a Reynolds number of 45,000. The flow was seeded with polystyrene particles and illuminated by a laser light sheet. Computational results were determined for the same configurations and at matching Reynolds numbers; these surface heat transfer coefficients and flow velocities were computed with a commercially available code. The experimental and computational results were compared. Although some general trends did agree, there were inconsistencies in the temperature patterns as well as in the numerical results. These inconsistencies strongly suggest the need for further computational studies on complicated geometries such as the one studied

Analysis of selected herbicide metabolites in surface and ground water of the United States

One of the primary goals of the US Geological Survey (USGS) Laboratory in Lawrence, Kansas, is to develop analytical methods for the analysis of herbicide metabolites in surface and ground water that are vital to the study of herbicide fate and degradation pathways in the environment. Methods to measure metabolite concentrations from three major classes of herbicides ─ triazine, chloroacetanilide and phenyl-urea ─ have been developed. Methods for triazine metabolite detection cover nine compounds: six compounds are detected by gas chromatography/mass spectrometry; one is detected by high-performance liquid chromatography with diode-array detection; and eight are detected by liquid chromatography/mass spectrometry. Two metabolites of the chloroacetanilide herbicides ─ ethane sulfonic acid and oxanilic acid ─ are detected by high-performance liquid chromatography with diode-array detection and liquid chromatography/mass spectrometry. Alachlor ethane sulfonic acid also has been detected by solid-phase extraction and enzyme-linked immunosorbent assay. Six phenylurea metabolites are all detected by liquid chromatography/mass spectrometry; four of the six metabolites also are detected by gas chromatography/mass spectrometry. Additionally, surveys of herbicides and their metabolites in surface water, ground water, lakes, reservoirs, and rainfall have been conducted through the USGS laboratory in Lawrence. These surveys have been useful in determining herbicide and metabolite occurrence and temporal distribution and have shown that metabolites may be useful in evaluation of non-point-source contamination

Initial beam-profiling tests with the NML prototype station at the Fermilab A0 Photoinjector

The beam-profile diagnostics station prototype for the superconducting rf electron linac being constructed at Fermilab at the New Muon Lab has been tested. The station uses intercepting radiation converter screens for the low-power beam mode: either a 100-\mu m thick YAG:Ce single crystal scintillator or a 1-\mu m thin Al optical transition radiation (OTR) foil. The screens are oriented with the surface perpendicular to the beam direction. A downstream mirror with its surface at 45 degrees to the beam direction is used to direct the radiation into the optical transport. The optical system has better than 20 (10) \mu m rms spatial resolution when covering a vertical field of view of 18 (5) mm. The initial tests were performed at the A0 Photoinjector at a beam energy of ~15 MeV and with micropulse charges from 25 to 500 pC for beam sizes of 45 to 250 microns. Example results will be presented.Comment: 3 pp. Particle Accelerator, 24th Conference (PAC'11) 2011. 28 Mar - 1 Apr 2011. New York, US

Observation of Coherently-Enhanced Tunable Narrow-Band Terahertz Transition Radiation from a Relativistic Sub-Picosecond Electron Bunch Train

We experimentally demonstrate the production of narrow-band ($\delta f/f \simeq20$% at $f\simeq 0.5$ THz) THz transition radiation with tunable frequency over [0.37, 0.86] THz. The radiation is produced as a train of sub-picosecond relativistic electron bunches transits at the vacuum-aluminum interface of an aluminum converter screen. We also show a possible application of modulated beams to extend the dynamical range of a popular bunch length diagnostic technique based on the spectral analysis of coherent radiation.Comment: 3 pages, 6 figure

Designing displaced lunar orbits using low-thrust propulsion

The design of spacecraft trajectories is a crucial task in space mission design. Solar sail technology appears as a promising form of advanced spacecraft propulsion which can enable exciting new space science mission concepts such as solar system exploration and deep space observation. Although solar sailing has been considered as a practical means of spacecraft propulsion only relatively recently, the fundamental ideas are by no means new (see McInnes1 for a detailed description). A solar sail is propelled by re ecting solar photons and therefore can transform the momentum of the photons into a propulsive force. This article focuses on designing displaced lunar orbits using low-thrust propulsion

Report of Messrs. Thurman, Washburne, & Cooley, Constituting an Advisory Committee on Differential Rates by Railroads Between the West and the Seaboard.

In January, 1882, the undersigned were notified that they had been selected by the New.York Central & Hudson River Railroad Company, W. H. Vanderbilt, P1·esident; the New York, Lake Erie & Western Railroad Company, H. J. Jewett, President; the Pennsylvania Railroad Company, G. B. Roberts, President, and the Baltimore & Ohio Railroad Company, John W. Garrett, President, to act as an Advisory Commission upon the differences in rates that should exist, both eastwardly and westwardly, upon all classes of freights between the several terminal Atlantic ports, and to report upon the same.https://repository.law.umich.edu/books/1037/thumbnail.jp

Information criteria for inhomogeneous spatial point processes

The theoretical foundation for a number of model selection criteria is established in the context of inhomogeneous point processes and under various asymptotic settings: infill, increasing domain, and combinations of these. For inhomogeneous Poisson processes we consider Akaike information criterion and the Bayesian information criterion, and in particular we identify the point process analogue of sample size needed for the Bayesian information criterion. Considering general inhomogeneous point processes we derive new composite likelihood and composite Bayesian information criteria for selecting a regression model for the intensity function. The proposed model selection criteria are evaluated using simulations of Poisson processes and cluster point processes.Comment: 6 figure

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Immune mechanisms have been implicated in placental dysfunction in patients with recurrent miscarriages and intrauterine growth restriction (IUGR), but the mediators are undefined. Here we show that complement activation, particularly C5a, is a required intermediary event in the pathogenesis of placental and fetal injury in an antibody-independent mouse model of spontaneous miscarriage and IUGR, and that complement activation causes dysregulation of the angiogenic factors required for normal placental development. Pregnancies complicated by miscarriage or growth restriction were characterized by inflammatory infiltrates in placentas, functional deficiency of free vascular endothelial growth factor (VEGF), elevated levels of soluble VEGF receptor 1 (sVEGFR-1, also known as sFlt-1; a potent anti-angiogenic molecule), and defective placental development. Inhibition of complement activation in vivo blocked the increase in sVEGFR-1 and rescued pregnancies. In vitro stimulation of monocytes with products of the complement cascade directly triggered release of sVEGFR-1, which sequesters VEGF. These studies provide the first evidence linking the complement system to angiogenic factor imbalance associated with placental dysfunction, and identify a new effector of immune-triggered pregnancy complications

Measurements of Heat Transfer, Flow, and Pressures in a Simulated Turbine Blade Internal Cooling Passage

An experimental study was made to obtain quantitative information on heat transfer, flow, and pressure distribution in a branched duct test section that had several significant features of an internal cooling passage of a turbine blade. The objective of this study was to generate a set of experimental data that could be used for validation of computer codes that would be used to model internal cooling. Surface heat transfer coefficients and entrance flow conditions were measured at nominal entrance Reynolds numbers of 45,000, 335,000, and 726,000. Heat transfer data were obtained by using a steady-state technique in which an Inconel heater sheet is attached to the surface and coated with liquid crystals. Visual and quantitative flow-field data from particle image velocimetry measurements for a plane at midchannel height for a Reynolds number of 45,000 were also obtained. The flow was seeded with polystyrene particles and illuminated by a laser light sheet. Pressure distribution measurements were made both on the surface with discrete holes and in the flow field with a total pressure probe. The flow-field measurements yielded flow-field velocities at selected locations. A relatively new method, pressure sensitive paint, was also used to measure surface pressure distribution. The pressure paint data obtained at Reynolds numbers of 335,000 and 726,000 compared well with the more standard method of measuring pressures by using discrete holes

Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD

Background: Facioscapulohumeral dystrophy (FSHD) is commonly associated with contraction of the D4Z4 macro-satellite repeat on chromosome 4q35 (FSHD1) or mutations in the SMCHD1 gene (FSHD2). Recent studies have shown that the clinical manifestation of FSHD1 can be modified by mutations in the SMCHD1 gene within a given family. The absence of either D4Z4 contraction or SMCHD1 mutations in a small cohort of patients suggests that the disease could also be due to disruption of gene regulation. In this study, we postulated that mutations responsible for exerting a modifier effect on FSHD might reside within remotely acting regulatory elements that have the potential to interact at a distance with their cognate gene promoter via chromatin looping. To explore this postulate, genome-wide Hi-C data were used to identify genomic fragments displaying the strongest interaction with the SMCHD1 gene. These fragments were then narrowed down to shorter regions using ENCODE and FANTOM data on transcription factor binding sites and epigenetic marks characteristic of promoters, enhancers and silencers